Results 51 to 60 of about 23,945 (282)

Frequency response areas of neurons in the mouse inferior colliculus. III. Time-domain responses: Constancy, dynamics, and precision in relation to spectral resolution, and perception in the time domain.

PLoS ONE, 2020
The auditory midbrain (central nucleus of inferior colliculus, ICC) receives multiple brainstem projections and recodes auditory information for perception in higher centers. Many neural response characteristics are represented in gradients (maps) in the
Marina A Egorova, Alexander G Akimov, Gleb D Khorunzhii, Günter Ehret   +3 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Walking blindfolded unveils unique contributions of behavioural approach and inhibition to lateral spatial bias [PDF]

, 2015
Healthy individuals display a tendency to allocate attention unequally across space, and this bias has implications for how individuals interact with their environments. However, the origins of this phenomenon remain relatively poorly understood.
Allen, John, Vasiljevic, M., Yao, B., Weick, Mario, Yao, Bo, Allen, JA, Yao, B, Vasiljevic, Milica, Weick, M., Allen, John A., Weick, M, Vasiljevic, M, Allen, J.   +12 more
core   +1 more source

The endogenous peptide antisecretory factor promotes tonic GABAergic signalling in CA1 stratum radiatum interneurons

Frontiers in Cellular Neuroscience, 2014
Tonic GABAergic inhibition regulates neuronal excitability and has been implicated to be involved in both neurological and psychiatric diseases. We have previously shown that the endogenous peptide antisecretory factor (AF) decreases phasic GABAergic ...
Joakim eStrandberg, Catarina eLindquist, Stefan eLange, Fredrik eAsztely, Eric eHanse   +4 more
doaj   +1 more source

Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex [PDF]

The Korean Journal of Physiology & Pharmacology, 2014
Phasic and tonic γ-aminobutyric acidA (GABAA) receptor-mediated inhibition critically regulate neuronal information processing. As these two inhibitory modalities have distinctive features in their receptor composition, subcellular localization of receptors, and the timing of receptor activation, it has been thought that they might exert distinct roles,
Joo, Kayoung, Yoon, Shin Hee, Rhie, Duck-Joo, Jang, Hyun-Jong   +3 more
openaire   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Differential control by 5-HT and 5-HT1A, 2A, 2C receptors of phasic and tonic GABAA inhibition in the visual thalamus [PDF]

, 2015
Thalamocortical (TC) neurons, including those of the dorsal lateral geniculate nucleus (dLGN), one of the visual sensory thalamic nuclei, exhibit two forms of GABAA receptor-mediated inhibition: phasic or classical inhibitory postsynaptic currents (IPSCs)
Vincenzo Crunelli, Giuseppe Di Giovanni, Crunelli, Vincenzo, Di Giovanni, Giuseppe   +3 more
core   +1 more source

Disinhibition Bursting of Dopaminergic Neurons

Frontiers in Systems Neuroscience, 2011
Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus.
Collin J Lobb, Todd W Troyer, Charles J Wilson, Carlos A Paladini   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source