Results 31 to 40 of about 23,945 (282)
Phasic GABAA‐mediated inhibition [PDF]
Epilepsia, 2010 Summaryγ‐Aminobutyric acid (GABA) is the main inhibitory transmitter in the central nervous system (CNS) and regulates via GABAA receptors tonic and phasic inhibition. This review focuses on the sequential steps leading to phasic inhibition, including vesicle exocytosis, dynamics of GABA transient in the synaptic cleft, binding to GABAA receptors ...
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Balancing tonic and phasic inhibition in hypothalamic corticotropin‐releasing hormone neurons [PDF]
The Journal of Physiology, 2018 Key points GABA transporter (GAT) blockade recruits extrasynaptic GABAA receptors (GABAARs) and amplifies constitutive presynaptic GABABR activity. Extrasynaptic GABAARs contribute to a tonic current. Corticosteroids increase the tonic current mediated by extrasynaptic GABAARs.
Phillip L.W. Colmers, Jaideep S. Bains
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Effect of GABAA Receptor Clustering on Phasic and Tonic Inhibition in the Hippocampus [PDF]
, 2004 Inhibitory transmission plays a major role in information processing in the brain since it integrates excitatory signals and defines the gain between neural input and output. γ-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the adult mammalian brain.
Petrini, Enrica Maria
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Heteromeric α/β glycine receptors regulate excitability in parvalbumin-expressing dorsal horn neurons through phasic and tonic glycinergic inhibition [PDF]
, 2017 The dorsal horn (DH) of the spinal cord is an important site for modality specific processing of sensory information and is essential for contextually relevant sensory experience.
B. A. Graham +9 more
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Neuronal specializations for the processing of interaural difference cues in the chick
Frontiers in Neural Circuits, 2014 Sound information is encoded as a series of spikes of the auditory nerve fibers (ANFs), and then transmitted to the brainstem auditory nuclei. Features such as timing and level are extracted from ANFs activity and further processed as the interaural time
Harunori eOhmori
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SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells. [PDF]
PLoS ONE, 2018 BACKGROUND:Hemorrhagic transformation is a major complication of ischemic stroke, is linked to matrix metalloproteinase-9 (MMP-9), and is exacerbated by tissue plasminogen activator (tPA).
Volodymyr Gerzanich +4 more
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Cocaine Inhibition of Nicotinic Acetylcholine ReceptorsInfluences Dopamine Release
Frontiers in Synaptic Neuroscience, 2014 Nicotinic acetylcholine receptors (nAChRs) potently regulate dopamine (DA) release in the striatum and alter cocaine’s ability to reinforce behaviors.
Alexandra eAcevedo-Rodriguez +7 more
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Scientific Reports, 2022 Dopaminergic neurons in the ventral tegmental area (VTA) play a crucial role in the processing of reward-related information. Recent studies with pharmacological manipulations of VTA neuronal activity demonstrated a VTA-induced immunoenhancement in ...
Tasuku Kayama +2 more
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The Journal of Physiology, 2008 The neural dynamics and mechanisms responsible for the transition from the interictal to the ictal state (seizures) are unresolved questions in epilepsy. It has been suggested that a shift from inhibitory to excitatory GABAergic drive can promote seizure generation.
M, Derchansky +5 more
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Frontiers in Psychology, 2015 The current study examines similarity or disparity of a frontally-mediated physiological response of mental effort among multiple executive functioning tasks between children and adults.
Dana Lynn Byrd +4 more
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