A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
eLife, 2022 Striatal spiny projection neurons (SPNs) transform convergent excitatory corticostriatal inputs into an inhibitory signal that shapes basal ganglia output.
Lior Matityahu +7 more
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Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons
Frontiers in Molecular Neuroscience, 2020 GABAA receptors mediate a large fraction of inhibitory neurotransmission in the central nervous system. Two major classes of GABAA receptors are γ2-containing receptors and δ-containing receptors, which are largely located synaptically and ...
Xinguo Lu +6 more
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Neurogliaform cells of amygdala: a source of slow phasic inhibition in the basolateral complex [PDF]
The Journal of Physiology, 2012 Key points The amygdala is a key brain structure implicated in processing emotions and is thought to underlie anxiety‐related behaviours. Interneurons of the basolateral amygdala provide constant silencing of principal cells, and are proven to be active cellular elements during emotional processing.
Mańko, Mirosława +3 more
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The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition [PDF]
, 2014 Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B. +5 more
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Modulating anxiety with extrasynaptic inhibition [PDF]
, 2014 Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood.
Botta, Paolo
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Aberrant GABA(A) receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. [PDF]
PLoS ONE, 2011 Aberrant γ-aminobutyric acid type A (GABA(A)) receptor-mediated inhibition in cortico-thalamic networks remains an attractive mechanism for typical absence seizure genesis.
Adam C Errington +3 more
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Frontiers in Neural Circuits, 2015 Prepulse inhibition (PPI) is understood as an inhibitory process that attenuates sensory flow during early stages (20-1000ms) of information processing. Here, we applied in vivo electrophysiology and pharmacology to determine if prepulse inhibition (PPI)
Paul C.P. Curtin, Thomas ePreuss
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Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons [PDF]
, 2006 The main inhibitory neurotransmitter in the mammalian brain, GABA, mediates multiple forms of inhibitory signals, such as fast and slow inhibitory postsynaptic currents and tonic inhibition, by activating a diverse family of ionotropic GABA(A) receptors (
Vogt, Kaspar E +11 more
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Frontiers in Neural Circuits, 2014 The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations during subunit assembly give rise to a variety of receptors with different functional properties. This heterogeneity results in variations in GABAergic conductances across
Vallent eLee, Jamie eMaguire
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Phasic Off responses of auditory cortex underlie perception of sound duration
Cell Reports, 2021 Summary: It has been proposed that sound information is separately streamed into onset and offset pathways for parallel processing. However, how offset responses contribute to auditory perception remains unclear.
Haifu Li +9 more
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