Phasic, Nonsynaptic GABA-A Receptor-Mediated Inhibition Entrains Thalamocortical Oscillations [PDF]
The Journal of Neuroscience, 2014 GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in thalamocortical rhythms, we focally deleted synaptic, γ2 subunit-containing GABA-ARs in the thalamus using ...
Rovo Zita +10 more
openaire +7 more sources
Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition [PDF]
Frontiers in Neural Circuits, 2013 In the central nervous system, GABA transporters (GATs) very efficiently clear synaptically released GABA from the extracellular space, and thus exert a tight control on GABAergic inhibition. In neocortex, GABAergic inhibition is heavily recruited during
Daniel Simon Razik +3 more
doaj +2 more sources
Relationship between tonic inhibitory currents and phasic inhibitory activity in the spinal cord lamina II region of adult mice [PDF]
Molecular Pain, 2006 Phasic and tonic inhibitions are two types of inhibitory activities involved in inhibitory processing in the CNS. In the spinal cord dorsal horn, phasic inhibition is mediated by both GABAergic and glycinergic inhibitory postsynaptic currents.
Ataka Toyofumi, Gu Jianguo G
doaj +2 more sources
Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm [PDF]
Neuron, 2009 Several aspects of perception, particularly those pertaining to vision, are closely linked to the occipital alpha (alpha) rhythm. However, how the alpha rhythm relates to the activity of neurons that convey primary visual information is unknown. Here we show that in behaving cats, thalamocortical neurons in the lateral geniculate nucleus (LGN) that ...
Lorincz, ML +4 more
core +8 more sources
Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons [PDF]
eLife, 2017 Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks.
Patrícia A Correia +5 more
doaj +3 more sources
MUSCARINIC LONG-TERM ENHANCEMENT OF TONIC AND PHASIC GABAA INHIBITION IN RAT CA1 PYRAMIDAL NEURONS [PDF]
Frontiers in Cellular Neuroscience, 2016 Acetylcholine (ACh) regulates network operation in the hippocampus by controlling excitation and inhibition in rat CA1 pyramidal neurons (PCs), the latter through gamma-aminobutyric acid type-A receptors (GABAARs).
Soledad Dominguez +2 more
doaj +2 more sources
Phasic inhibition of dopamine neurons is an instrumental punisher [PDF]
Behavioral Neuroscience, 2020 Abstract It is well established that the activity of VTA dopamine neurons is sufficient to serve as a Pavlovian reinforcer but whether this activity can also serve as instrumental reinforcer is less well understood. Here we studied the effects of optogenetic inhibition of VTA dopamine neurons in instrumental conditioning preparations ...
Constance Y. Peng +4 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2022 Interferon-γ (IFN-γ), a cytokine with neuromodulatory properties, has been shown to enhance inhibitory transmission. Because early inhibitory neurotransmission sculpts functional neuronal circuits, its developmental alteration may have grave consequences.
Noah Döhne +5 more
doaj +1 more source
The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex [PDF]
The Korean Journal of Physiology and Pharmacology, 2010 Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABA(A) receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic ...
Hyun-Jong, Jang +5 more
openaire +2 more sources
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Neurobiology of Stress, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli +3 more
doaj +1 more source