Regulation of output spike patterns by phasic inhibition in cerebellar granule cells [PDF]
Frontiers in Cellular Neuroscience, 2014 The complex interplay of multiple molecular mechanisms taking part to synaptic integration is hard to disentangle experimentally. Therefore, we developed a biologically realistic computational model based on the rich set of data characterizing the ...
Thierry Ralph Nieus +4 more
doaj +8 more sources
Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition [PDF]
eLife, 2022 Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically involved in producing rapid network oscillations and cortical microcircuit computations, but the significance of PV+ axon myelination to the temporal features of inhibition
Mohit Dubey +6 more
doaj +9 more sources
Corrigendum: Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. [PDF]
Frontiers in Cellular Neuroscience, 2016 The corrigendum is needed in the acknowledgments section, since a funding agency was erroneously forgotten. We request therefore to add the sentence: .… and by grants of the Italian Ministry of Health (RF-2009-1475845) to ED. So that the full corrected paragraph will become:
Thierry Ralph Nieus +4 more
doaj +4 more sources
Phasic inhibition as a mechanism for generation of rapid respiratory rhythms. [PDF]
Proc Natl Acad Sci U S A, 2017 Significance Humans breathe ∼20,000 times per day and hundreds of millions of times over the average life span. The neural mechanisms which control respiratory rate are poorly understood. Although it was previously thought that the signal to breathe was solely an excitatory command, we show that selective ...
Cregg JM +4 more
europepmc +4 more sources
Tonic GABAA receptor currents in Cerebellar Purkinje cells of wild-type and DMDmdx mice [PDF]
Scientific ReportsCerebellar Purkinje cells (PCs) fire spontaneously and depend heavily on inhibition to modify their activity. While phasic inhibition is well-described in PCs, the presence and mechanisms of tonic inhibitory currents, low amplitude currents resulting ...
Shaarang Mitra +2 more
doaj +2 more sources
Homeostatic Competition between Phasic and Tonic Inhibition [PDF]
Journal of Biological Chemistry, 2013 The GABAA receptors are the major inhibitory receptors in the brain and are localized at both synaptic and extrasynaptic membranes. Synaptic GABAA receptors mediate phasic inhibition, whereas extrasynaptic GABAA receptors mediate tonic inhibition. Both phasic and tonic inhibitions regulate neuronal activity, but whether they regulate each other is not ...
Zheng Wu, Ce Zhang, Yuting Bai
exaly +3 more sources
Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus [PDF]
Nature Communications, 2016 The development and function of thalamic interneurons is only partially understood. Here the authors describe the unexpected mesencephalic origin of the GABAergic interneurons of the visual thalamus that provide both phasic and tonic modulation of ...
Polona Jager +9 more
doaj +5 more sources
Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. [PDF]
PLoS Biology, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca(2+)-stimulated release of various gliotransmitters, including glutamate and ATP.
Ulyana Lalo +5 more
doaj +5 more sources
Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice [PDF]
Scientific ReportsLocus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe +7 more
doaj +2 more sources
Modulation of response inhibition with event-related atVNS showed EEG but no behavioral effects [PDF]
Scientific ReportsResponse inhibition can be explained within the theory of event coding. Event file binding and reconfiguration have previously been studied in relation to various neurotransmitters.
Leonie F. Becker +8 more
doaj +2 more sources