Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme [PDF]
Beilstein Journal of Organic Chemistry, 2023 Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular modelling combined with spectrophotometric experiments revealed that in neutral and acidic ...
Josipa Matić +8 more
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Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids [PDF]
Molecules, 2018 In this study, we report the synthesis, antibacterial and anticancer evaluation of 38 novel phenanthridines that were designed as analogs of the benzo[c]phenanthridine alkaloids. The prepared phenanthridines differ from the benzo[c]phenanthridines in the
Pavel Lasák +3 more
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Dichloridobis(phenanthridine-κN)zinc(II) [PDF]
Acta Crystallographica Section E, 2009 In the molecule of the title compound, [ZnCl2(C13H9N)2], the ZnII atom is four-coordinated in a distorted tetrahedral configuration by two N atoms from two phenanthridine ligands and by two terminal Cl atoms.
Zeinab Khoshtarkib +4 more
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Synthesis of phenanthridines via palladium-catalyzed picolinamide-directed sequential C–H functionalization [PDF]
Beilstein Journal of Organic Chemistry, 2013 We report a new synthesis of phenanthridines based on palladium-catalyzed picolinamide-directed sequential C–H functionalization reactions starting from readily available benzylamine and aryl iodide precursors.
Ryan Pearson +4 more
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Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives
Frontiers in Oncology, 2019 Based on the structure of sanguinarine, fourteen phenanthridine derivatives were designed and synthesized in the current study. The cytotoxic activities of synthesized compounds were evaluated against five human cancer cell lines (MCF-7, PC3, Hela, A549,
Minghui Wan +7 more
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Selective C‐7 Functionalization of Phenanthridines by Microwave‐Assisted Claisen Rearrangements of 8‐Allyloxyphenanthridines [PDF]
ChemistryOpen, 2023 Carbon‐carbon bond formation in the phenanthridine 7‐position was achieved by microwave‐assisted Claisen rearrangement of 8‐allyloxyphenanthridines. The reactions took place with excellent regioselectivity and high chemical yields.
Mathias Ryslett Lepsøe +2 more
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Influence of Solvent Polarity and DNA-Binding on Spectral Properties of Quaternary Benzo[c]phenanthridine Alkaloids. [PDF]
PLoS ONE, 2015 Quaternary benzo[c]phenanthridine alkaloids are secondary metabolites of the plant families Papaveraceae, Rutaceae, and Ranunculaceae with anti-inflammatory, antifungal, antimicrobial and anticancer activities.
Michal Rájecký +3 more
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Microwave assisted synthesis of phenanthridine derivatives via Suzuki coupling and condensation
Results in Chemistry, 2021 One-pot synthesis of phenanthridine derivatives using appropriately substituted aromatic ortho-bromo N-tosylhydrazones and 2′-aminobenzeneboronic acid pinacol esters is described.
Satheesh Kumar Dende +3 more
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Zephycandidine A and Synthetic Analogues—Synthesis and Evaluation of Biological Activity [PDF]
MoleculesA convenient total synthesis of the imidazo[1,2-f]phenanthridine-type Amaryllidaceae alkaloid zephycandidine A (3) was developed, which further allowed us to perform modifications of substituents on benzenoid ring A and imidazole ring D.
Thomas Klaßmüller +5 more
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Structurally Simple Phenanthridine Analogues Based on Nitidine and Their Antitumor Activities
Molecules, 2019 A series of novel structurally simple analogues based on nitidine was designed and synthesized in search of potent anticancer agents. The antitumor activity against human cancer cell lines (HepG2, A549, NCI-H460, and CNE1) was performed by 3-(4,5 ...
Shu-Qin Qin +4 more
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