Results 21 to 30 of about 1,044 (124)

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Nitrogen‐Centered Organic Persistent Radicals Catalyze Redox‐Neutral C─C Bond Forming Reactions

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
Kuhn verdazyls, discovered over 60 years ago, are shown as effective catalysts for the first time. Their tunable redox properties enable organocatalytic redox‐neutral C─H arylation and C─H trifluoromethylation reactions without light activation.
Shrouq Mujahed, Jaysan Janabel, Kundan Shaw, Roberta Cagliani, Tynchtyk Amatov   +4 more
wiley   +2 more sources

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

A Hypoxia‐Responsive Near‐Infrared Phosphorescence Nanoprobe for High‐Sensitive Detection of Tumor Cells and Imaging of Colorectal Cancer In Situ

Aggregate, Volume 7, Issue 1, January 2026.
We have successfully developed a hypoxia‐responsive near‐infrared phosphorescent probe, Ir‐PEG. This nanoprobe demonstrates high sensitivity, water solubility, and deep‐tissue penetration. It remains specifically activatable even in the hypoxic intestinal environment, facilitating high‐contrast imaging of orthotopic colon cancer.
Jian Chen, Huamin Lan, Sensen Zhou, Weizhi Chen, Xu Zhen, Xiqun Jiang   +5 more
wiley   +1 more source

Photo‐Autocatalysis: Insights From Light‐Driven Self‐Catalyzed Organic Transformations

Chemistry – An Asian Journal, Volume 21, Issue 2, 28 January 2026.
This perspective highlights recent advancements in photo‐autocatalytic reactions—light‐driven processes characterized by self‐accelerating kinetics. We explore the underlying mechanisms, demonstrating how photo‐autocatalysis can be realized either through a single photo‐autocatalyst or through a combination of a photocatalyst and an autocatalyst, and ...
James Shao‐Jiun Yang, Aira Shayne Paculba, Hsuan‐Hung Liao   +2 more
wiley   +1 more source

Substitution Kinetics, DNA/BSA Interactions, Cytotoxicity Evaluation and Computational Analysis of [bis‐(azaaryl)amine)Pt(II)/Pd(II)Cl] Complexes, Azaaryl = Quinoline or Phenanthridine

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
The search for metal‐based anticancer agents with improved efficacy and reduced side effects is ongoing. The activities of these anticancer drugs depend on their aqueous stability, substitutional reactivity at target sites (cytotoxicity) and nontarget sites (toxicity), as well as their transportation and cell bioavailability.
Phakamani C. Dlamini, Thato T. Medupe, Lucy W. Macharia, Karabo Serala, Sharon Prince, Gregory S. Smith, Irvin N. Booysen, Allen Mambanda, Franc Perdih   +8 more
wiley   +1 more source

Studies on the electrochemical reactions of 1-amino phosphonates

Electrochemistry Communications
Electrochemical direct conversion of 1-aminoalkylphosphonates into novel heteroaromatic compounds has been studied and described. Cyclicvoltametry analysis showed that 1-aminoalkylphosphonate was oxidized in the anode, followed by removing the phosphoryl
Babak Kaboudin, Milad Behroozi, Fahimeh Varmaghani, Haruhiko Fukaya   +3 more
doaj   +1 more source

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Rapid Access to Emission‐Tunable Organelle‐Targeted Aggregation‐Induced Emission Luminogens Through One‐Pot Skeletal Editing

Transformative Chemistry, Volume 1, Issue 1, December 2025.
Herein we report a skeletal editing strategy for rapidly transforming readily available isoquinolines into synthetically challenging (dihydrodibenzo[c,i]phenanthridin‐6‐yl)diphenylphosphine oxides (DHBPPO) derivatives. These DHBPPO derivatives exhibit tunable emission, aggregation‐induced emission (AIE) properties, organelle‐targeted specificity, and ...
Yanling Liu, Chaoyang Li, Yunlong Qin, Yifan Cheng, Jianing Zhang, Yang Zhao, Tianhao Wu, Chenghan He, Cheng Xu, Qilin Wang, Zheng Zhao, Ben Zhong Tang   +11 more
wiley   +1 more source

Multistep Reactions Initiated by Amine‐Based Organometallic Methods

European Journal of Organic Chemistry, Volume 28, Issue 40, October 29, 2025.
The advent of C–H activation and other organometallic methodologies making use of transient directing groups or free amines themselves for the elaboration of amine substrates provides unique access to cascade‐type reactions that can generate significant molecular complexity in one pot. The pursuit of atom‐ and step‐economical pathways to access complex
Victoria D. Ho, Olutayo N. Farinde, Kendra K. Shrestha, Michael C. Young   +3 more
wiley   +1 more source