Results 71 to 80 of about 30,643 (283)

Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat [PDF]

, 2010
YesBackground: Asenapine is a new pharmacological agent for the acute treatment of schizophrenia and bipolar disorder. It has relatively higher affinity for serotonergic and α2-adrenergic than dopaminergic D2 receptors.
Abdul-Monim, Abdul-Monim, Abdul-Monim, Addington, Aghajanian, Amargos-Bosch, Anand, Bilder, Cuesta, Depoortere, Didriksen, Drake, Erik H.F. Wong, Fleischhaker, Fleming, Franberg, Goldberg, Gray, Grayson, Green, Harvey, Hatcher, Hirst, Huang, Hugh M. Marston, Idris, Idris, Jentsch, Jentsch, Jentsch, Jentsch, Jo C. Neill, Jones, Kapur, Keefe, Krystal, Lewis, Marcus, Marston, Martin, McIntyre, McLean, McLean, McLean, Mohammed Shahid, Nagi F. Idris, Neill, Olney, O’Grada, Potkin, Samantha L. McLean, Schmidt, Schotte, Shahid, Smith, Snigdha, Sutcliffe, Sutcliffe, Tait, Tarazi, Tarazi, Terranova, Wolff   +62 more
core   +1 more source

Nickel‐Catalyzed Twofold Conjunctive Coupling via Philicity‐Alternating Radical Relay

Advanced Science, EarlyView.
Herein, we disclose a nickel‐catalyzed twofold conjunctive coupling that enables a four‐component assembly involving an activated alkene, a 1,3‐enyne, and both alkyl and aryl halides. Multiple C–C bonds are selectively constructed through a philicity‐alternating radical relay and the selective radical capture by the nickel catalyst.
Ji Hwan Jeon, Da Hye Kim, Gun Ha Kim, Gyuhwan Sim, Jan‐Uwe Rohde, Byunghyuck Jung, Sangwon Seo, Sung You Hong   +7 more
wiley   +1 more source

PCP-based mice models of schizophrenia: differential behavioral, neurochemical and cellular effects of acute and subchronic treatments [PDF]

, 2015
Rationale N-methyl-D-aspartate receptor (NMDA-R) hypofunction has been proposed to account for the pathophysiology of schizophrenia. Thus, NMDA-R blockade has been used to model schizophrenia in experimental animals.
Artigas, Francesc, Castañé, Anna, Santana, Noemí   +2 more
core   +1 more source

Pacinian Corpuscle‐Inspired Strain Conversion Enables Ultrasensitive, Linear, and Broad‐Range Piezoelectric Sensing for Cardiovascular Health Monitoring

Advanced Science, EarlyView.
A bioinspired piezoelectric sensor mimicking Pacinian corpuscles is developed to enable ultrasensitive and linear pressure sensing. A multilayer grooved architecture converts normal pressure into in‐plane strain, delivering high sensitivity, wide linear range, and efficient energy harvesting, enabling high‐fidelity wrist pulse monitoring and ...
Qi Yang, Zhongqian Song, Shengjie Liu, Yingming Ma, Weiyan Li, Huijun Kong, Cuiyu Liu, Yu Bao, Li Niu   +8 more
wiley   +1 more source

Recent changes in drug abuse scenarios : The new/novel psychoactive substances (NPS) phenomenon [PDF]

, 2018
© 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Peer ...
Schifano, Fabrizio
core   +2 more sources

Affinity‐Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6‐PP‐InsP5‐Binding Proteins in Plants

Advanced Science, EarlyView.
ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter, Verena Gaugler, Sara Christina Stolze, Riya Ghosh, Akhila Jayamon, Ranjana Yadav, Felix Wollensack, Debabrata Laha, Hirofumi Nakagami, Gabriel Schaaf, Henning Jacob Jessen   +10 more
wiley   +1 more source

Rescue of cognitive and negative-like symptoms by chronic aripiprazole treatment in a 3-hit mouse model of neurodevelopmental disorder

Frontiers in Pharmacology
IntroductionCognitive and negative symptoms remain among the most disabling features of schizophrenia but are still poorly addressed by existing antipsychotics.
Imane Mouffok, Noa Roudaut, Cécile Chofflet, Thomas Freret, Michel Boulouard, Valentine Bouet   +5 more
doaj   +1 more source

Using molecular similarity to highlight the challenges of routine immunoassay-based drug of abuse/toxicology screening in emergency medicine

BMC Emergency Medicine, 2009
Background Laboratory tests for routine drug of abuse and toxicology (DOA/Tox) screening, often used in emergency medicine, generally utilize antibody-based tests (immunoassays) to detect classes of drugs such as amphetamines, barbiturates ...
Siam Mohamed G, Pizon Anthony F, Krasowski Matthew D, Giannoutsos Spiros, Iyer Manisha, Ekins Sean   +5 more
doaj   +1 more source

Cannabidiol Attenuates Sensorimotor Gating Disruption and Molecular Changes Induced by Chronic Antagonism of NMDA receptors in Mice [PDF]

, 2015
Background: Preclinical and clinical data suggest that cannabidiol (CBD), a major non-psychotomimetic compound from Cannabis sativa, induces antipsychotic-like effects.
Del Bel, Elaine A., Ferreira, Frederico R., Gomes, Felipe V., Guimarães, Francisco S., Issy, Ana Carolina, Viveros, María Paz   +5 more
core   +2 more sources

Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Poria cocos is known as an edible mushroom for food and medicine. Poria cocos and its terpenes and terpenoids serve as novel remedies to treat diabetes and its ulcers. Its mode of actions includes reduction of insulin resistance, starch digestion and inflammation as well as promotion of blood vessel formation. ABSTRACT Poria cocos is a medicinal fungus
Yi‐San Lee, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +3 more
wiley   +1 more source