Results 51 to 60 of about 23,005 (222)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

Comparison of Antidepressant‐Like and Abuse‐Related Effects of Phencyclidine in Rats [PDF]

, 2014
Preclinical Research N ‐methyl‐D‐aspartate ( NMDA ) receptor antagonists, such as ketamine, have emerged as novel candidate treatments for major depressive disorder, but abuse potential of these agents is a concern.
S. Stevens Negus, Joseph H. Porter, Hillhouse, Todd M., Negus, S. Stevens, Porter, Joseph H., Todd M. Hillhouse   +5 more
core   +1 more source

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling

Advanced Science, EarlyView.
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha, Di Feng, Ziru Xue, Zhiying Liu, Xiaochen Lin, Zhe Wang, Ling Xu, Jasper Fuk Woo Chan, Martin Cheung, Michael Shing Yan Huen, Yusong Guo, Kui Ming Chan, Yun Liu, Bo Gao   +13 more
wiley   +1 more source

The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats

Acta Veterinaria
Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology.
Ivaz Sava, Puškaš Nela, Paunović Bojana, Stojković Tihomir, Nikolić Tatjana, Bogosavljević Milica Velimirović, Živković Milica, Petronijević Nataša   +7 more
doaj   +1 more source

A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits

Brain Sciences
Background/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is essential ...
Imane Mouffok, Caroline Lahogue, Thomas Cailly, Thomas Freret, Valentine Bouet, Michel Boulouard   +5 more
doaj   +1 more source

Ketamine Hydrochloride - a useful drug for the field immobilization of the Spotted Hyaena Crocuta Crocuta

Koedoe: African Protected Area Conservation and Science, 1973
The use of Ketamine hydrochloride (Vetalar, Parke-Davis) for the capture and restraint of five spotted hyaenas (Crocuta crocuta) is discussed. The wide margin of safety andrelatively short recovery period associated with Ketamine makeit a useful ...
G.L. Smuts
doaj   +1 more source

NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1994
The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs.
R. Shafik, N. Eshba, M. El-Semary, M. Abdel-Kreem   +3 more
doaj   +1 more source

Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate [PDF]

, 1986
This study presents experimental evidence for the mediation of a behavioral effect of phencyclidine-like drugs by inhibition of neurotransmission at excitatory synapses utilizing N-methyl-aspartate (NMA) receptors by showing that -2-amino-5 ...
Kleer, Eduardo, Woods, James H., Koek, Wouter, Mudar, Pamela J.   +3 more
core   +1 more source

Place‐based risk: Examining relationships between adolescent perceptions of community risk factors and adolescent substance use across geographic contexts

American Journal of Community Psychology, EarlyView.
Abstract Mixed evidence for the influence of structural and social factors on adolescent substance use behaviors exists across the rural–urban continuum. Therefore, this study explores how adolescent perceptions of structural and social community risk factors are associated with lifetime and past 30‐day use of alcohol, marijuana, cigarettes, and ...
Melissa Pearman Fenton, Sarah D. Lynne, Josie L. Bryan, Catherine Woodstock Striley, Larry F. Forthun   +4 more
wiley   +1 more source

Clozapine Prevents a Decrease in Neurogenesis in Mice Repeatedly Treated With Phencyclidine

Journal of Pharmacological Sciences, 2007
It has recently been suggested that neurogenesis in the dentate gyrus is decreased in schizophrenia and this phenomenon may contribute to the pathogenesis of the disorder.
Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma, Kiyofumi Yamada   +7 more
doaj   +1 more source