Results 41 to 50 of about 30,843 (202)

Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine

Brain Sciences, 2013
Anesthetic and anti-epileptic drugs used in pediatric and obstetric medicine and several drugs, including alcohol, that are abused by pregnant women, trigger widespread neuroapoptosis in the developing brain of several animal species, including non-human
Catherine E. Creeley, John W. Olney, Carla M. Yuede   +2 more
doaj   +1 more source

Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation [PDF]

, 2017
yesRationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and is a thoroughly validated ...
Andrew MJ Young, Joanna C Neill, Michael K Harte, Paxinos G, Samantha L McLean, Snigdha S, Yee BK   +6 more
core   +2 more sources

Interaction of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats [PDF]

, 2017
Patients with schizophrenia smoke cigarettes at a higher rate than the general population. We hypothesized that a factor in this comorbidity is sensitivity to the reinforcing and reinforcement- enhancement effects of nicotine.
Li, Ming, Mulholland, Michele M, Schulz, Tiffany D., Swalve, Natashia   +3 more
core   +1 more source

Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model. [PDF]

, 2015
Schizophrenia is a neuropsychiatric disorder affecting 1% of the world's population. Due to both a broad range of symptoms and disease heterogeneity, current therapeutic approaches to treat schizophrenia fail to address all symptomatic manifestations of ...
Bahn, Sabine, Guest, Paul C, Holmes, Elaine, Rahmoune, Hassan, Want, Elizabeth J, Wesseling, Hendrik   +5 more
core   +9 more sources

False-Positive Phencyclidine (PCP) Result on 11-Panel Urine Drug Screen (UDS) in a 17-Year-Old Adolescent with Long-Term Venlafaxine Use

Case Reports in Psychiatry, 2023
Venlafaxine is an antidepressant belonging to the class of serotonin–norepinephrine reuptake inhibitors that are US Food and Drug Administration-approved to treat and manage symptoms of depression, anxiety, and other mood disorders in adults. We describe
Hyun Sue Kim, Aakash Jain, Anita S. Kablinger   +2 more
doaj   +1 more source

Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods. [PDF]

, 2018
One of the objectives of the Adolescent Brain Cognitive Development (ABCD) Study (https://abcdstudy.org/) is to establish a national longitudinal cohort of 9 and 10 year olds that will be followed for 10 years in order to prospectively study the risk and
Bartsch, Hauke, Conway, Kevin P, Feldstein Ewing, Sarah W, Goldstein, Rita Z, Gonzalez, Raul, Heitzeg, Mary, Lisdahl, Krista M, Nixon, Sara Jo, Sher, Kenneth J, Tapert, Susan   +9 more
core   +2 more sources

The Effects of Perinatal Phencyclidine Administration on the Density and Branching of Astrocytes in the Brain of Aged Rats

Acta Veterinaria
Phencyclidine (PCP), an antagonist of the N-methyl-D-aspartate glutamate receptor (NMDA-R), is used for modeling schizophrenia in animals, as NMDA-R hypofunction is vital in its pathophysiology.
Ivaz Sava, Puškaš Nela, Paunović Bojana, Stojković Tihomir, Nikolić Tatjana, Bogosavljević Milica Velimirović, Živković Milica, Petronijević Nataša   +7 more
doaj   +1 more source

A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficits

Brain Sciences
Background/Objectives: Cognitive deficits and negative symptoms associated with schizophrenia are poorly managed by current antipsychotics. In order to develop effective treatments, refining animal models of neurodevelopmental disorders is essential ...
Imane Mouffok, Caroline Lahogue, Thomas Cailly, Thomas Freret, Valentine Bouet, Michel Boulouard   +5 more
doaj   +1 more source

Ketamine Hydrochloride - a useful drug for the field immobilization of the Spotted Hyaena Crocuta Crocuta

Koedoe: African Protected Area Conservation and Science, 1973
The use of Ketamine hydrochloride (Vetalar, Parke-Davis) for the capture and restraint of five spotted hyaenas (Crocuta crocuta) is discussed. The wide margin of safety andrelatively short recovery period associated with Ketamine makeit a useful ...
G.L. Smuts
doaj   +1 more source

Clozapine Prevents a Decrease in Neurogenesis in Mice Repeatedly Treated With Phencyclidine

Journal of Pharmacological Sciences, 2007
It has recently been suggested that neurogenesis in the dentate gyrus is decreased in schizophrenia and this phenomenon may contribute to the pathogenesis of the disorder.
Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma, Kiyofumi Yamada   +7 more
doaj   +1 more source