Results 31 to 40 of about 30,843 (202)

The role of setting for ketamine abuse: clinical and preclinical evidence [PDF]

, 2012
Drug abuse is often seen as a unitary phenomenon, partly as a result of the discovery over the past three decades of shared mechanisms of action for addictive substances. Yet the pattern of drug taking is often very different from drug to drug.
Sprenger, Stewart, Tellier, Topp, Triffleman, Vollenweider, Vollenweider, Weir, White   +8 more
core   +1 more source

The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia

Frontiers in Behavioral Neuroscience, 2018
PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson’s disease and haloperidol-induced extrapyramidal ...
Ritesh P. Daya, Jayant Bhandari, Sharnpreet K. Kooner, Joella Ho, Christopher D. Rowley, Nicholas A. Bock, Troy Farncombe, Ram K. Mishra   +7 more
doaj   +1 more source

Recreational use, analysis and toxicity of tryptamines [PDF]

, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio, Pantano, Flaminia, Romolo, Francesco Saverio, Tittarelli, Roberta   +3 more
core   +1 more source

Profiles of VGF Peptides in the Rat Brain and Their Modulations after Phencyclidine Treatment

Frontiers in Cellular Neuroscience, 2017
From the VGF precursor protein originate several low molecular weight peptides, whose distribution in the brain and blood circulation is not entirely known.
Barbara Noli, Fabrizio Sanna, Carla Brancia, Filomena D’Amato, Barbara Manconi, Federica Vincenzoni, Irene Messana, Maria R. Melis, Antonio Argiolas, Gian-Luca Ferri, Cristina Cocco   +10 more
doaj   +1 more source

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine [PDF]

, 2008
Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate ...
A Baskys, A Breier, A Meister, A Meister, AJ Cochilla, AK Malhotra, Aric Madayag, AW MacDonald III, AY Shih, B Moghaddam, B Moghaddam, D Jabaudon, DA Baker, DA Baker, David A Baker, DC Javitt, DD Schoepp, DD Schoepp, DE Featherstone, DM Barch, DP Purohit, DR Weinberger, DS Gupta, DS Lorrain, E Pileblad, ED Luby, F Faltus, F Sams-Dodd, G Hu, G Hu, G Kohr, G Paxinos, GD Pearlson, GJ Marek, H Augustin, H Homayoun, H Sato, H Sies, HB Uylings, HF Bradford, Ilangovan Raju, J Cartmell, J Kilbride, JA Lieberman, James H Meador-Woodruff, JB Manent, JH Cabungcal, JH Krystal, JH Krystal, JM Williamson, JY Kim, K Aoyama, KQ Do, L Lu, Lars V Kristiansen, LE Chavez-Noriega, M D'Ascenzo, M Herrera-Marschitz, M Verhage, ME Jackson, MM Moran, O Valenti, P Steullet, PD Harvey, R Corbett, R Takahata, S Bannai, S Chaki, SA Petersen, SJ Sigrist, SM Deneke, Vahram Haroutunian, W Hauber, W Timmerman, WA Abbott, WE Bunney, Y Huang, ZX Xi, ZX Xi   +78 more
core   +2 more sources

Delayed presentation of a firearm injury in a patient with recent use of phencyclidine: A case report

Trauma Case Reports, 2020
The rapid delivery of care for penetrating traumatic injury, such as gunshot wounds, is essential to minimizing the morbidity and mortality rate. It is highly unusual for a patient who has sustained a firearm injury to present over 24 h after the event ...
Rebecca Siegel, Babak Sarani, Andrew C. Meltzer   +2 more
doaj   +1 more source

Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field [PDF]

, 2009
YesFemale hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a seven-day washout period. Rats were challenged with acute PCP or vehicle and tested for
Abekawa, T., JC Neill, ML Woolley, SL McLean   +3 more
core   +1 more source

Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects

Journal of Pharmacological Sciences, 2008
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin, Phil Ho Lee, Hyun Ji Kim, Toshitaka Nabeshima, Hyoung-Chun Kim   +4 more
doaj   +1 more source

Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences, 2006
.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative ...
Tomohisa Mori, Mutsuko Nomura, Kazumi Yoshizawa, Hiroshi Nagase, Toshiko Sawaguchi, Minoru Narita, Tsutomu Suzuki   +6 more
doaj   +1 more source

Sex Differences in Aripiprazole Sensitization from Adolescence to Adulthood [PDF]

, 2018
The present study investigated the potential sex differences in repeated aripiprazole (ARI) treatment-induced behavioral sensitization from adolescence to adulthood, and to determine whether ARI sensitization can be transferred to olanzapine (OLZ) and/or
Chow, Shinnyi, Davis, Collin, Freeman, Elizabeth, Li, Ming, Lin, Joanne   +4 more
core   +1 more source