Results 11 to 20 of about 23,005 (222)
Frontiers in Pharmacology, 2013 Antagonism of N-methyl-D-aspartate (NMDA) receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile.
Wendy K Adams +3 more
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Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decomposition [PDF]
, 2011 The quantification of experimentally-induced alterations in biological pathways remains a major challenge in systems biology. One example of this is the quantitative characterization of alterations in defined, established metabolic pathways from complex ...
Dawson, Neil +24 more
core +6 more sources
Phencyclidine disposition and reversal of toxicity by monoclonal antibody.
, 1989 A physiologic model for phencyclidine disposition in the rat was established. This model was able to accurately predict phencyclidine disposition in most rat tissues.
Bozigian, Haig Philip.
core +5 more sources
Cells, 2022 Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal slice
Michael Spedding +18 more
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Frontiers in Molecular Neuroscience, 2020 Background: It has been consistently reported that the deficiency of the adenosine triphosphate (ATP) sensitive purinergic receptor P2X7 (P2X7R) ameliorates symptoms in animal models of brain diseases.Objective: This study aimed to investigate the role ...
Stefano Calovi +14 more
doaj +1 more source
Phencyclidine-induced behavioral sensitization [PDF]
, 1994 Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization.
Xu, Xiaojuan, Domino, Edward F.
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Neurobiology of Disease, 2004 Acute phencyclidine induces schizophrenia-like symptoms in healthy humans and psychotic episodes in schizophrenics. Although phencyclidine is known as a N-methyl d-aspartate receptor antagonist (NMDA-R), the molecular events underlying the behavioral ...
Sergio Kaiser +7 more
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European Psychiatry, 2023 Introduction Zebrafish (Danio rerio) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic a targeted phenotype, particularly behavioral typologies and specific attributes comparable to murine models
I. B. Nita +5 more
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Increased Cortical Nitric Oxide Release After Phencyclidine Administration [PDF]
, 2009 Phencyclidine exerts psychotomimetic effects in humans and is used as a pharmacological animal model for schizophrenia. We, and others, have demonstrated that phencyclidine induces cognitive deficits in rats that are associated with schizophrenia ...
Svensson, Lennart +13 more
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Pridopidine Reverses Phencyclidine-Induced Memory Impairment
Frontiers in Pharmacology, 2018 Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R).
Kristoffer Sahlholm +7 more
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