Results 21 to 30 of about 23,005 (222)

Neonatal manifestations of maternal phencyclidine exposure [PDF]

open access: yes, 1987
Golden et al, Maternal phencyclidine use and neonatal manifestations ...
Susan Martier   +10 more
core   +1 more source

Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor

open access: yesJournal of Pharmacological Sciences, 2010
Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects ...
Eun-Joo Shin   +10 more
doaj   +1 more source

The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor. [PDF]

open access: yesPLoS ONE, 2013
In this paper we determined the pharmacological profiles of novel ketamine and phencyclidine analogues currently used as 'designer drugs' and compared them to the parent substances via the resources of the National Institute of Mental Health Psychoactive
Bryan L Roth   +6 more
doaj   +1 more source

Anaesthetic phencyclidine, blocker of the ATP-sensitive potassium channels [PDF]

open access: yes, 1994
The double sucrose gap and patch-clamp studies revealed that phencyclidine blocked the ATP-sensitive K+ channel in isolated cardiac cells (half-maximal inhibition at ≈20 μM; Hill coefficient ≈1).
Alekseev, Alexey E.   +9 more
core   +1 more source

Persistence of phencyclidine in fetal brain [PDF]

open access: yes, 1987
Phencyclidine residues were found in the brains of rat pups of mothers dosed with this drug during pregnancy. These levels were significant at times after dosing when maternal levels of phencyclidine in serum or brain were low or undetectable.
Ahmad, G, Halsall, LC, Bondy, SC
core   +1 more source

Health disparities in chronic liver disease

open access: yesHepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian   +3 more
wiley   +1 more source

The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia

open access: yesFrontiers in Behavioral Neuroscience, 2018
PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson’s disease and haloperidol-induced extrapyramidal ...
Ritesh P. Daya   +7 more
doaj   +1 more source

Ketamine-induced neurotoxicity in neurodevelopment: A synopsis of main pathways based on recent in vivo experimental findings

open access: yesJournal of Anaesthesiology Clinical Pharmacology, 2021
Ketamine, a phencyclidine derivative and N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used as an anesthetic, analgesic, and sedative agent in daily pediatric practice.
Konstantina Kalopita   +4 more
doaj   +1 more source

Phencyclidine-induced catalepsy in pigeons: Specificity and stereoselectivity [PDF]

open access: yes, 1984
A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs.
Rice, Kenner C.   +5 more
core   +1 more source

Structural and Functional Siderophore Remodeling by Enzymatic Delipidation

open access: yesAngewandte Chemie, EarlyView.
A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog   +5 more
wiley   +2 more sources

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