Results 61 to 70 of about 30,843 (202)

D1-like receptor activation improves PCP-induced cognitive deficits in animal models: Implications for mechanisms of improved cognitive function in schizophrenia [PDF]

, 2009
YesPhencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced deficits in the novel object recognition (NOR ...
Abdul-Monim, Abdul-Monim, Abdul-Monim, Amico, Apud, Arnsten, Benes, Benes, Briggs, Brown, Buchanan, Cahill, Castner, Ciliax, Creese, Davis, Dawson, Finger, Fletcher, Fletcher, George, Goldman-Rakic, Goldman-Rakic, Grace, Granon, Gray, Grayson, Grayson, Green, Guillin, Hagan, Hagger, Harvey, Haut, Hersi, Hirvonen, Ichikawa, Idris, Javitt, Jentsch, Jentsch, Jentsch, Joanna C. Neill, Kashima, Kebabian, Keefe, Kolb, Lahti, Lawler, Levey, Lidow, Lieberman, Marder, Marie L. Woolley, McAlonan, McLean, McLean, Meador-Woodruff, Meltzer, Meunier, Mu, Murray, Nagi F. Idris, Neill, Neill, Neumeyer, Okubo, Pantelis, Qandil, Rossi, Samantha L. McLean, Sawaguchi, Seeman, Siuciak, Snigdha, Snigdha, Snigdha, Snigdha, Spano, Steele, Sutcliffe, Sutcliffe, Tait, Tunbridge, Vincent   +84 more
core   +1 more source

Hyperactivity of Endoplasmic Reticulum Associated Exocytosis Mechanism Contributes to Acute Phencyclidine Intoxication

Journal of Pharmacological Sciences, 2004
Phencyclidine (PCP) produces schizophrenia-like psychosis and acute PCP-intoxications; however, whether glutamate/NMDA-receptor blockade by PCP modulates or not these mechanisms has remained to be clarified.
Gang Zhu, Motohiro Okada, Daishi Uchiyama, Tadashi Ohkubo, Shukuko Yoshida, Sunao Kaneko   +5 more
doaj   +1 more source

Aisha Bano - The Role of KCNQ (Kv7) Potassium Channels in Schizophrenia Deficits [PDF]

, 2013
For years, studies have been conducted to treat the positive and negative symptoms and cognitive deficits of schizophrenia; it has allowed to treat the positive symptoms through regulation of dopaminergic neurons and dopamine pathways; however, we still ...
Bano, Aisha
core   +1 more source

Comparison of the efficacy of two anticonvulsants, phenytoin and valproate to improve PCP and d-amphetamine induced deficits in a reversal learning task in the rat

Frontiers in Behavioral Neuroscience, 2009
Recent studies in our laboratory have shown that PCP (phencyclidine) and d-amphetamine induce a cognitive deficit in rats, in a paradigm of potential relevance for the pathology of schizophrenia.
Nagi F Idris, JO C Neill, Charles H Large   +2 more
doaj   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

Identification of a New Psychoactive Substances of Phencyclidine-type, 2-Oxo-PCPr in Seized e-Cigarette Oil

Zhipu Xuebao
The new psychoactive substances (NPSs) are defined as a category of substances of abuse, either in a pure form or a preparation, that are not listed in the control table by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on ...
Jia-lei WU, Qiang ZHANG, Xue-hu WANG, Ling-yun LIU, Li-qi CHEN, Rui-hua WANG, Fang-min XU   +6 more
doaj   +1 more source

Inducible nitric oxide inhibitors block NMDA antagonist-stimulated motoric behaviors and medial prefrontal cortical glutamate efflux

Frontiers in Pharmacology, 2015
Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects
Hadley C Bergstrom, Altaf eDavesh, Altaf eDavesh, S Paul Berger   +3 more
doaj   +1 more source

Onondaga, County of and CSEA Local 1000, AFSCME, AFL-CIO, Onondaga County Local 843 [PDF]

, 2015
In the matter of the fact-finding between the Onondaga County, employer, and the CSEA Local 1000, AFSCME, AFL-CIO, Onondaga County Local 843, union. PERB case no. M2013-298. Before: Michael G.
Whelan, Michael G
core   +1 more source

A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats [PDF]

, 2007
YesRationale The NMDA receptor antagonist, phencyclidine (PCP), has been shown to induce symptoms characteristic of schizophrenia. A loss in executive function and the ability to shift attention between stimulus dimensions is impaired in schizophrenia;
Abdul-Monim, Abdul-Monim, Abdul-Monim, Arnt, Benes, Benes, Berg, Birrell, Buchanan, Chesler, Cochran, Dawson, Deschênes, Didriksen, Downes, Egerton, Elvevag, Fletcher, Gartlon, Gilbertson, Grayson, Grayson, Hagger, Harvey, Hashimoto, Hatcher, Haut, Idris, Idris, Javitt, Jentsch, Jentsch, Joanna C. Neill, Jonathan P. Beck, Kapur, Kapur, Kapur, Kolb, Leysen, Lieberman, Marie L. Woolley, McLean, Meltzer, Nabeshima, Neill, Nuechterlein, Nuechterlein, Olney, Olney, Pantelis, Roberts, Rodefer, Rossi, Samantha L. McLean, Shelnutt, Siegfried, Snigdha, Sullivan, Sutcliffe, Tenn, Tyson, Yonezawa   +61 more
core   +1 more source

Preparation of the Phencyclidine Analogues (Part II) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1993
Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide.
Mohammad Raouf Darvich, Afsaneh Zonoozi
doaj