Results 21 to 30 of about 6,565 (223)
Network-based drug repurposing for potential stroke therapy
Computational and Structural Biotechnology Journal, 2023 Stroke is the leading cause of death and disability worldwide, with a growing number of incidences in developing countries. However, there are currently few medical therapies for this disease.
Qihui Wu +5 more
doaj +1 more source
Clomipramine Induced Extrapyramidal Symptoms: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 Extra Pyramidal Symptoms (EPS) are a group of symptoms that include dystonia, bradykinesia, tremor, akathisia, and tardive dyskinesia. They are caused by the blockage of D2 receptors in the nigro-striatal pathway and the imbalanced acetyl choline ...
Disha Mukherjee +2 more
doaj +1 more source
European Psychiatry, 2022 Introduction Use of Monoamine Oxidase Inhibitors (MAOIs) has experimented an important reduction in recent years, being replaced by other antidepressant drugs (ADs) associated with a better safety profile.
L. Olivier Mayorga +5 more
doaj +1 more source
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]
, 2017 INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M +8 more
core +2 more sources
Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]
, 2018 Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian +3 more
core +2 more sources
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]
, 2017 Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David +4 more
core +1 more source
Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis [PDF]
, 2018 Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental ...
Acosta, Glen +8 more
core +1 more source
Frontiers in Immunology, 2019 Macrophages play an important role in regulating the tumor microenvironment (TME). Here we show that classical (M1) macrophage polarization reduced expression of LSD1, nuclear REST corepressor 1 (CoREST), and the zinc finger protein SNAIL.
Abel H. Y. Tan +7 more
doaj +1 more source
Pharmaceuticals, 2020 Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to ...
Christian Carpéné +8 more
doaj +1 more source
Frontiers in Genetics, 2021 Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according to ...
Koya Fukunaga +8 more
doaj +1 more source