Journal of Pharmacy & Pharmaceutical Sciences, 2008 PURPOSE. To compare phenelzine (PLZ), an antidepressant drug with anxiolytic properties which inhibits monoamine oxidase (MAO) but also elevates rat brain levels of the amino acids ?-aminobutyric acid (GABA) and alanine (ALA), with vigabatrin (VIG ...
Kathryn G. Todd, Glen B. Baker
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A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing
Case Reports in Medicine, 2015 A 27-year-old Caucasian female with a history of depression was admitted to our local hospital with vague events that occurred a day before. This included an episode of dysarthria, and unsteadiness, followed by feeling generally unwell.
A. Malik, N. Junglee
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Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors [PDF]
International Journal of Neuropsychopharmacology, 2015 Background: Monoamine oxidase inhibitors (MAOIs) are being developed for major depressive disorder, Alzheimer’s, and Parkinson’s Disease. Newer MAOIs have minimal sensitivity to tyramine, but a key limitation for optimizing their development is that ...
Lina Chiuccariello +10 more
semanticscholar +2 more sources
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1 [PDF]
ACS Chemical Biology, 2014 Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 (H3K4Me1, H3K4Me2) and can contribute to gene silencing.
P. Prusevich +21 more
semanticscholar +2 more sources
Cognitive‐behavioral group therapy versus phenelzine in social phobia: Long term outcome [PDF]
, 1999 To evaluate the effects of maintenance treatment and durability of gains after treatment discontinuation, responders to either phenelzine (PZ) or cognitive-behavioral group therapy (CBGT) from an acute trial comparing these two treatments as well as pill
Michael R. Liebowitz +11 more
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Brainstem levels of transcription factor AP-2 in rat are changed after treatment with phenelzine, but not with citalopram. [PDF]
, 2005 BACKGROUND: Before therapeutic effect is obtained after treatment with antidepressant drugs, like serotonin selective reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAO-Is) there is an initial lag-period ...
Cecilia Berggård +2 more
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Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception
Molecular and Cellular Neuroscience, 2023 Katelyn A. Bustin +13 more
semanticscholar +3 more sources
Drug-Related Hypertension: A Disproportionality Analysis Leveraging the FDA Adverse Event Reporting System. [PDF]
J Clin Hypertens (Greenwich)ABSTRACT Hypertension exerts a significant global disease burden, adversely affecting the well‐being of billions. Alarmingly, drug‐related hypertension remains an area that has not been comprehensively investigated. Therefore, this study is designed to utilize the adverse event reports (AERs) from the US Food and Drug Administration's Adverse Event ...
Zhu H, Pan L, Lui H, Zhang J.
europepmc +2 more sources
Transcranial magnetic stimulation–associated mania with psychosis: A case report [PDF]
Mental Health Clinician, 2021 Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of ...
Knox Erin D. PharmD, BCPP +1 more
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Nanoformulation improves antitumor efficacy of MAOI immune checkpoint blockade therapy without causing aggression-related side effects. [PDF]
Front Pharmacol, 2022 MAOIs, a well-established class of antidepressant that operate through the inhibition of monoamine oxidase to increase available serotonin, have recently been identified as a surprisingly effective candidate for the circumvention of tumor-induced immune ...
Brown J +9 more
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