Results 21 to 30 of about 8,267 (256)

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury [PDF]

Journal of Neurochemistry, 2016
Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega‐Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao, Riyi Shi   +11 more
openalex   +2 more sources

Lysine-Specific Demethylase 1 Inhibitors: A Comprehensive Review Utilizing Computer-Aided Drug Design Technologies [PDF]

Molecules
Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising therapeutic target for treating various cancers (such as breast cancer, liver cancer, etc.) and other diseases (blood diseases, cardiovascular diseases, etc.), owing to its observed ...
Di Han, Jiarui Lu, Baoyi Fan, Wenfeng Lu, Yiwei Xue, Meiting Wang, Taigang Liu, Shaoli Cui, Qinghe Gao, Yingchao Duan, Yongtao Xu   +10 more
doaj   +2 more sources

Phenelzine treatment increases transcription factor AP-2 levels in rat brain [PDF]

, 2003
Mattias Damberg, Cecilia Berggård, Lars Oreland   +2 more
openalex   +3 more sources

Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception

Molecular and Cellular Neuroscience, 2023
Katelyn A. Bustin, Kyosuke Shishikura, Irene Chen, Zongtao Lin, Nate R. McKnight, Yuxuan Chang, Xie Wang, Jing Jing Li, Eric Arellano, Liming Pei, Paul D. Morton, Ann M. Gregus, Matthew W. Buczynski, Megan L. Matthews   +13 more
openalex   +3 more sources

The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents. [PDF]

Pharmacol Res Perspect
Distinct mechanisms of viability decreasing actions of selegiline in androgen‐insensitive PC3 and sensitive 22Rv1 PAC cell lines. MAO‐B inhibition in the mitochondrial membrane of PC3 cells leads to the upregulation of the BAX and downregulation of FOX and GLUT1 which potentially results in reduced glucose uptake and apoptosis induction.
Steib A, Pohóczky K, Tóth N, Kormos V, Kun J, Kálai T, Mangel L, Mátyus P, Helyes Z.   +8 more
europepmc   +2 more sources

Transcranial magnetic stimulation–associated mania with psychosis: A case report [PDF]

Mental Health Clinician, 2021
Transcranial magnetic stimulation (TMS) is a noninvasive procedure used in the treatment of depression. We observed TMS-associated mania with psychotic symptoms in a 55-year-old male diagnosed with MDD and generalized anxiety disorder without history of ...
Knox Erin D. PharmD, BCPP, Bota Robert G. MD   +1 more
doaj   +1 more source

Correction to "The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents". [PDF]

Pharmacol Res Perspect
Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
europepmc   +2 more sources

A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED)

Frontiers in Oncology, 2022
ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression.
Thiru Prasanna, Thiru Prasanna, Thiru Prasanna, Laeeq Malik, Laeeq Malik, Robert D. McCuaig, Wen Juan Tu, Fan Wu, Pek Siew Lim, Abel H. Y. Tan, Jane E. Dahlstrom, Jane E. Dahlstrom, Philip Clingan, Eugene Moylan, Jeremy Chrisp, David Fuller, Sudha Rao, Desmond Yip, Desmond Yip   +18 more
doaj   +1 more source

Nanoformulation improves antitumor efficacy of MAOI immune checkpoint blockade therapy without causing aggression-related side effects

Frontiers in Pharmacology, 2022
MAOIs, a well-established class of antidepressant that operate through the inhibition of monoamine oxidase to increase available serotonin, have recently been identified as a surprisingly effective candidate for the circumvention of tumor-induced immune ...
James Brown, Zhe Li, Xi Wang, Yu Jeong Kim, Yu-Chen Wang, Yanning Zuo, Yanning Zuo, Weizhe Hong, Weizhe Hong, Pin Wang, Bo Li, Lili Yang, Lili Yang, Lili Yang, Lili Yang   +14 more
doaj   +1 more source

National Prescribing Trends and Cost Analysis of Antidepressants, Anxiolytics, and Hypnotics in England, 2010-2023. [PDF]

Hum Psychopharmacol
ABSTRACT Introduction We describe prescribing of anxiolytics/hypnotics/antidepressants at an all‐England level between 2010 and 2023, taking account of the influence of the COVID‐19 pandemic‐period. Methods All Primary Care Prescribing data for England for anxiolytics/hypnotics/antidepressant agents taken as tablets or capsules from 1 January 2010 to ...
Stedman M, Davies M, Levy JW, Ingram J, Taylor D, Heald A.   +5 more
europepmc   +2 more sources