Results 31 to 40 of about 7,825 (259)

Attenuation of the effects of oxidative stress by the MAO-inhibiting antidepressant and carbonyl scavenger phenelzine.

Chemico-Biological Interactions, 2019
G. Baker, D. Matveychuk, Erin M Mackenzie, A. Holt, Yanlin Wang, S. Kar   +5 more
semanticscholar   +2 more sources

Phenelzine Mitochondrial Functional Preservation and Neuroprotection after Traumatic Brain Injury Related to Scavenging of the Lipid Peroxidation-Derived Aldehyde 4-Hydroxy-2-Nonenal [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2013
I. Singh, Lesley K. Gilmer, Darren M. Miller, John E. Cebak, Juan A. Wang, E. Hall   +5 more
semanticscholar   +2 more sources

Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants. [PDF]

Adv Ther (Weinh)
The experimental 3D structures of five prevalent commercial antidepressants (reboxetine, pipofezine, ansofaxine, phenelzine, and bifemelane) in their drug formulation states are first elucidated by microcrystal electron diffraction (MicroED) directly from powdered materials.
Lin J, Bu G, Unge J, Gonen T.
europepmc   +2 more sources

PCLAF-DREAM drives alveolar cell plasticity for lung regeneration. [PDF]

Nat Commun
Cell plasticity, changes in cell fate, is crucial for tissue regeneration. In the lung, failure of regeneration leads to diseases, including fibrosis. However, the mechanisms governing alveolar cell plasticity during lung repair remain elusive.
Kim B, Huang Y, Ko KP, Zhang S, Zou G, Zhang J, Kim MJ, Little D, Ellis LV, Paschini M, Jun S, Park KS, Chen J, Kim C, Park JI.   +14 more
europepmc   +2 more sources

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury [PDF]

Journal of Neurochemistry, 2016
Zhe Chen, Jonghyuck Park, Breanne Butler, G. Acosta, Sasha Vega-Alvarez, Lingxing Zheng, Jonathan Tang, R. McCain, Wenpeng Zhang, Ouyang Zheng, Peng Cao, R. Shi   +11 more
semanticscholar   +2 more sources

A Phase 1 Proof of Concept Study Evaluating the Addition of an LSD1 Inhibitor to Nab-Paclitaxel in Advanced or Metastatic Breast Cancer (EPI-PRIMED)

Frontiers in Oncology, 2022
ObjectiveLysine-Specific Demethylase-1 (LSD1) is overexpressed in breast cancer cells and facilitate mesenchymal properties which may contribute to therapeutic resistance and cancer progression.
Thiru Prasanna, Thiru Prasanna, Thiru Prasanna, Laeeq Malik, Laeeq Malik, Robert D. McCuaig, Wen Juan Tu, Fan Wu, Pek Siew Lim, Abel H. Y. Tan, Jane E. Dahlstrom, Jane E. Dahlstrom, Philip Clingan, Eugene Moylan, Jeremy Chrisp, David Fuller, Sudha Rao, Desmond Yip, Desmond Yip   +18 more
doaj   +1 more source

Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine

Cellular and molecular neurobiology, 2021
Phenelzine (PLZ) is a monoamine oxidase (MAO)-inhibiting antidepressant with anxiolytic properties. This multifaceted drug has a number of pharmacological and neurochemical effects in addition to inhibition of MAO, and findings on these effects have ...
D. Matveychuk, Erin M Mackenzie, David Kumpula, M. Song, A. Holt, S. Kar, K. Todd, P. Wood, G. Baker   +8 more
semanticscholar   +1 more source

Neuroprotection by acrolein sequestration through exogenously applied scavengers and endogenous enzymatic enabling strategies in mouse EAE model. [PDF]

Sci Rep
We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor in MS pathology. In this study, we found that the acrolein scavenger hydralazine (HZ), when applied from the day of induction, can suppress acrolein and alleviate ...
Tang J, Alford A, Leung G, Tully M, Shi R.   +4 more
europepmc   +2 more sources

Evolution of ideas about the risk of tyramine syndrome developing during therapy with irreversible non-selective monoamine oxidase inhibitors (to the 70th anniversary of the first use of this group of antidepressants)

Неврология, нейропсихиатрия, психосоматика, 2022
We describe the history of studying of the problem of tyramine syndrome during the treatment with antidepressants, irreversible non-selective monoamine oxidase inhibitors. Data on clinical observations are presented.
D. S. Danilov, M. Yu. Brovko
doaj   +1 more source

The History of Irreversible Non-Selective MAOI Antidepressants in Russia (for their 70th Anniversary)

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2023
The history of irreversible non-selective MAOI antidepressants in the USSR and Russia is systemized. The history of representatives’ appearance is described. The history of the study of pharmacological effects is highlighted.
D. S. Danilov
doaj   +1 more source