Biomarker-driven drug repurposing for NAFLD-associated hepatocellular carcinoma using machine learning integrated ensemble feature selection. [PDF]
Front BioinformThe incidence of non-alcoholic fatty liver disease (NAFLD), encompassing the more severe non-alcoholic steatohepatitis (NASH), is rising alongside the surges in diabetes and obesity.
Ghosh S, Mandal SD, Thakur S.
europepmc +2 more sources
Clomipramine Induced Extrapyramidal Symptoms: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 Extra Pyramidal Symptoms (EPS) are a group of symptoms that include dystonia, bradykinesia, tremor, akathisia, and tardive dyskinesia. They are caused by the blockage of D2 receptors in the nigro-striatal pathway and the imbalanced acetyl choline ...
Disha Mukherjee +2 more
doaj +1 more source
Phase 2 Trial of Monoamine Oxidase Inhibitor Phenelzine in Biochemical Recurrent Prostate Cancer
Prostate Cancer and Prostatic Diseases, 2020 Purpose Monoamine oxidase A (MAOA) influences prostate cancer growth and metastasis in pre-clinical models. We examined effects of phenelzine (a monoamine oxidase inhibitor) in patients with biochemical recurrent castrate-sensitive prostate cancer ...
M. Gross +7 more
semanticscholar +1 more source
Angiosarcoma of liver associated with phenelzine. [PDF]
BMJ, 1979 J W Bradfield, G L Scott, T K Daneshmend
openaire +5 more sources
European Psychiatry, 2022 Introduction Use of Monoamine Oxidase Inhibitors (MAOIs) has experimented an important reduction in recent years, being replaced by other antidepressant drugs (ADs) associated with a better safety profile.
L. Olivier Mayorga +5 more
doaj +1 more source
Feeling blue to seeing red: A case of escitalopram-induced epistaxis. [PDF]
Clin Case RepKey Clinical Message Selective serotonin reuptake inhibitors are associated with an increased risk of bleeding, most commonly intracranial and gastric bleeding, especially in conjunction with anticoagulant use. Although uncommon, escitalopram is associated with epistaxis in a dose‐dependent manner. Dosage reduction may be sufficient in management.
Ogundare T, Ologun OA.
europepmc +2 more sources
HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. [PDF]
, 2017 Most studies of HIV latency focus on the peripheral population of resting memory T cells, but the brain also contains a distinct reservoir of HIV-infected cells in microglia, perivascular macrophages, and astrocytes.
Alvarez-Carbonell, David +4 more
core +1 more source
A meta-analysis of pharmacotherapy for social anxiety disorder: an examination of efficacy, moderators, and mediators [PDF]
, 2017 INTRODUCTION: Social anxiety disorder (SAD) is among the most prevalent mental disorders, associated with impaired functioning and poor quality of life. Pharmacotherapy is the most widely utilized treatment option.
Borenstein M +8 more
core +2 more sources
The evaluation of isatin analogues as inhibitors of monoamine oxidase
Chemical Biology &Drug Design, Volume 102, Issue 5, Page 1067-1074, November 2023., 2023 Isatin is a reversible inhibitor of monoamine oxidase (MAO). This study investigated the SARs of MAO inhibition by isatin analogues and discovered five compounds with IC50 < 1 μM. 4‐Chloroisatin and 5‐bromoisatin were the most potent inhibitors of MAO‐A and MAO‐B, respectively.
Izak F. Prinsloo +3 more
wiley +1 more source
Frontiers in Genetics, 2021 Variability in the enzymatic activity of N-acetyltransferase 2 (NAT2) is an important contributor to interindividual differences in drug responses. However, there is little information on functional differences in N-acetylation activities according to ...
Koya Fukunaga +8 more
doaj +1 more source