Results 61 to 70 of about 8,267 (256)

Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish

Frontiers in Neuroscience, 2020
Besides several endogenous elements, exogenous factors, including exposure to pesticides, have been recognized as putative factors contributing to the onset and development of neurodegenerative diseases, including Parkinson’s disease (PD).
Thomson Patrick Joseph, Nataraj Jagadeesan, Liu Yang Sai, Stanley Li Lin, Stanley Li Lin, Sudhanshu Sahu, Melitta Schachner, Melitta Schachner   +7 more
doaj   +1 more source

Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants [PDF]

, 1996
Background: This study investigated differences in cognitive performance between middle-aged adults with and without a lifetime history of mood disorder features, adjusting for a range of potential confounders.
Cullen, B., Deary, I..J., Evans, J.J., Gallacher, J., Mackay, D.F., Martin, D., McIntosh, A., Nicholl, B.I., Pell, J.P., Smith, D.J., Ul-Haq, Z.   +10 more
core   +2 more sources

Saccharomyces cerevisiae Yeast‐Based Supplement and Breast Milk Supply: A Randomised Placebo‐Controlled Trial

Maternal &Child Nutrition, EarlyView.
Maternal brewer's yeast supplementation did not change the milk oligosaccharide (HMO) concentration, but more mothers felt their milk supply was increased, and fewer reported formula use by 6 months postpartum compared to those taking the placebo. This suggests the supplement may support breastfeeding, warranting further investigation in larger trials.
Lili Jia, Louise Brough, Janet L. Weber
wiley   +1 more source

Atypical Depression [PDF]

, 2013
Atypical depression is defined as a specifier of major depressive disorder. Columbia criteria for atypical depression are commonly used to make a diagnosis.
Ahmet Koyuncu, Erhan Ertekin, Selim Sağır, Zerrin Binbay   +3 more
core   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Assessing Condition‐Specific Adverse Event Profiles of Modafinil for Labelled and Off‐Label Uses: A Systematic Review and Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jaehee Jung, Jaeyoon Youm, Jihyun Kang, Ah‐Young Kim, Jae Kyung Suh, Hye‐Young Kang   +5 more
wiley   +1 more source

Older patients' prescriptions screening in the community pharmacy: development of the Ghent Older People's Prescriptions community Pharmacy Screening (GheOP3S) tool [PDF]

, 2015
Background: Ageing of the population often leads to polypharmacy. Consequently, potentially inappropriate prescribing (PIP) becomes more frequent. Systematic screening for PIP in older patients in primary care could yield a large improvement in health ...
Boussery, Koen, Mehuys, Els, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, van der Cammen, Tischa   +5 more
core   +5 more sources

Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels

Acta Pharmaceutica, 2017
γ-Ethyl-γ-phenyl-butyrolactone (EFBL) is a structural combination of the anticonvulsant γ-hydroxy-γ-ethyl-γ-phenylbutyramide (HEPB) and the hypnotic γ-butyrolactone (GBL), which inherits both properties. To clarify its mechanism of action, the effects of
Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega   +2 more
doaj   +1 more source

Epigenetic therapy in urologic cancers: an update on clinical trials [PDF]

, 2016
Epigenetic dysregulation is one of many factors that contribute to cancer development and progression. Numerous epigenetic alterations have been identified in urologic cancers including histone modifications, DNA methylation changes, and microRNA ...
Agarwal, Aggarwal, Alon, Anant, Arbor, Bassi, Bastian, Bates, Baylin, Benevolenskaya, Bologna, Borden, Burris, Cairns, Cairns, Carducci, Carducci, Catto, Chi, Clark, Clark, Cole, Croce, Croce, Dahiya, Dahiya, de Balincourt, de Bono, de Bono, Domingos, Dorr, Ehtejab, Eisen, Eisenberger, Eisenberger, Eisenhauer, Eisenhauer, Ekström, Ellinger, Ferrari, Festuccia, Fuessel, Fuessel, Gleave, Grant, Gregory, Griffiths, Han, Harland, Heinrich, Helin, Helin, Hennenlotter, Hsiao, Huang, Hussain, Investigators, Investigators, Issa, Jemal, Jeronimo, Jones, Kiltie, Kim, Kim, Kouzarides, Kouzarides, Kristiansen, Kristiansen, Liang, Liang, Lin, Lyko, Maitland, Manoharan, Marks, Martel, Martell, Meeran, Muller, Nelson, Ochiya, Ogawa, Osman, Pectasides, Pili, Pili, Pompidou, Ren, Rudek, Sartor, Sawyers, Schellhammer, Scher, Sediqe, Shariat, Shi, Sidransky, Sukumar, Tewari, Tolcher, Tolcher, Torti, Verma, Verma, Visakorpi, Von Hoff, Von Ruecker, Wilding, Winquist, Wu, Ørntoft   +111 more
core   +1 more source

Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1). [PDF]

PLoS Pathogens, 2011
The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle
Naoki Sakane, Hye-Sook Kwon, Sara Pagans, Katrin Kaehlcke, Yasuhiro Mizusawa, Masafumi Kamada, Kara G Lassen, Jonathan Chan, Warner C Greene, Martina Schnoelzer, Melanie Ott   +10 more
doaj   +1 more source