Results 101 to 110 of about 55,451 (338)
Advanced Science, EarlyView.The study shows that RPAP2, acting as an oncoprotein, promotes hepatocellular carcinoma (HCC) progression, with its stability being negatively regulated by FBXW7, yet positively by HSP90 and USP7. The FBXW7‐RPAP2 axis plays a crucial role in controlling HCC cell growth and influencing liver cell differentiation.
Danrui Cui +14 more
wiley +1 more source
Cancer Medicine, Volume 11, Issue 24, Page 4767-4783, December 2022., 2022 1. In this study, we observed that mucinous breast cancer with metastatic lymph nodes have a worse prognosis and identified tumor size, grade and age as independent risk factors of lymph node metastasis. 2. we constructed a nomogram with factors of tumor size, grade, age and developed a risk classification system for predicting the risk of lymph node ...
Shuang‐Ling Wu +4 more
wiley +1 more source
The Efficacy of Once-Daily Dose of Phenobarbital in Children with Generalized Tonic-Clonic Epilepsy
Paediatrica Indonesiana, 2018 In spite of its long half life, phenobarbital is still given twice-daily in the treatment of generalized tonic-clonic epilepsy. This study aims to determine if daily dose of phenobarbital given once differs to that given twice daily.
Amril A. Burhany +2 more
doaj +1 more source
Advanced Science, EarlyView.Prostate and bladder cancers activate genes and pathways similar to those in the developmental stage by aggregating and analyzing current data. In this process, sex hormones and their receptors maybe a key role in causing and reversing the “cold” and “hot” immune tumor phenotypes, potentially enhancing the immune response.
Dengxiong Li +16 more
wiley +1 more source
The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages
Cell Biochemistry and Function, Volume 40, Issue 8, Page 914-925, December 2022., 2022 Abstract ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for membrane protein targeting and activity, vesicle biogenesis, and barrier function.
Valentina E. Gómez‐Mellado +7 more
wiley +1 more source
Sedative Effects of Intraperitoneal Diazepam in Mice
International Journal of Integrated Health Sciences, 2023 Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and ...
Marsha Vania +3 more
doaj
Effects of Prenatal Exposure to Phenobarbital on Verbal Abilities in School-Aged Children [PDF]
, 2020 Phenobarbital is one of the oldest medications used for the treatment of epilepsy. Although its use has declined in many developed nations, phenobarbital is still a first-line treatment in several developing countries across the globe.
Lutes, Jocelyn M.
core +1 more source
Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens. [PDF]
, 2012 In recent years, accumulating evidence supports the importance of microRNAs in liver physiology and disease; however, few studies have examined the involvement of these noncoding genes in chemical hepatocarcinogenesis.
Currie, RA +3 more
core +1 more source
Advanced Science, EarlyView.An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han +15 more
wiley +1 more source
Catheterization and Cardiovascular Interventions, Volume 100, Issue 7, Page 1195-1205, December 1, 2022., 2022 Abstract Objectives Investigate age‐related changes in coronary microvascular function, its effect on hyperemic and non‐hyperemic indices of stenosis relevance, and its prognostic implications. Background Evidence assessing the effect of age on fractional flow reserve (FFR), resting mean distal intracoronary pressure/mean aortic pressure (Pd/Pa), and ...
Daniel Faria +15 more
wiley +1 more source