Results 21 to 30 of about 36,304 (274)

Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital.

Biological and Pharmaceutical Bulletin, 1997
Molecularly imprinted polymer (MIP) was prepared against phenobarbital using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross linking monomer. We analyzed the recognition properties of the phenobarbital MIP. In some organic solvents, imprinted polymer showed selective binding to phenobarbital.
Y, Tomioka, Y, Kudo, T, Hayashi, H, Nakamura, M, Niizeki, T, Hishinuma, M, Mizugaki   +6 more
openaire   +3 more sources

Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit

BMC Pediatrics, 2018
Background Although neonates and young infants with cholestasis are commonly treated with either phenobarbital or ursodeoxycholic acid (ursodiol), there is no evidence that phenobarbital is effective for this indication.
Tamorah Lewis, Simisola Kuye, Ashley Sherman   +2 more
doaj   +1 more source

The effectiveness of continuous venovenous hemodiafiltration in phenobarbital intoxication

Acta Medica International, 2018
Phenobarbital continues to be widely used in childhood epilepsy. Incorrect drug prescription can sometimes lead to intoxication, particularly in young children.
Yasemin Çoban, Dinçer Yildizdas, Özden Özgür Horoz, Nagehan Aslan, Didar Arslan   +4 more
doaj   +1 more source

Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs

BMC Pharmacology and Toxicology, 2022
Background The gut microbiome, a new organ of the body, can potentially alter the pharmacokinetics of orally administered drugs through microbial enzymes.
Imran Mukhtar, Haseeb Anwar, Arslan Iftikhar, Heba E. Hashem, Qasim Ali, Farhan Siddique   +5 more
doaj   +1 more source

Stimulation of cholesterol 7α-hydroxylase by phenobarbital in two strains of rats

Journal of Lipid Research, 1972
The effect of phenobarbital administration on the in vitro activity of cholesterol 7α-hydroxylase was investigated in two strains of rats. In rats of the Wistar strain the daily injection of phenobarbital (100 mg/kg per day ip for 5 days) produced a 33 ...
S. Shefer, S. Hauser, E.H. Mosbach
doaj   +1 more source

Measurement of Blood Phenobarbital Concentration in Newborns Admitted to The NICU of Imam Reza Hospital and Receiving The Drug Via Intravenous Mode [PDF]

Asia Pacific Journal of Medical Toxicology
Introduction: Newborns may be treated with phenobarbital for many reasons. Because in each region, depending on different races and genetic factors, different pharmacokinetic conditions govern the drug.
Hamidreza Goldouzi, Ashraf Mohammadzadeh, Ahmadshah Farhat, Anahita Alizadeh, F Yazdanpanah, Tina Loghmani, Ezzat Khodashenas   +6 more
doaj   +1 more source

Behavioral and structural changes in the hippocampus of wistar epileptic rats are minimized by acupuncture associated or not with phenobarbital

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2022
The aim of this study was to analyze the behavior and histopathological changes in the hippocampus of epileptic Wistar rats treated with acupuncture associated or not with phenobarbital.
T.C.C. Silva, A.A. N. Silva, Y.K.V. Serafim, V.A. Silva Júnior, E.R. Lima   +4 more
doaj   +1 more source

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
doaj   +1 more source

MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]

PLoS ONE, 2012
Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu, Sawako Shindo, Takemi Yoshida, Satoshi Numazawa   +3 more
doaj   +1 more source

Phenobarbital Pharmacokinetics and Optimal Dosing of Phenobarbital

Pediatric Neurology Briefs, 2018
Researchers from the Baylor College of Medicine in Houston, TX, USA, conducted a retrospective population pharmacokinetic analysis of 355 patients ages less than 19 years of age in the inpatient setting who were initiated on intravenous or oral ...
Safiullah Shareef, Murtaza Nasir Ali
doaj   +1 more source