Results 21 to 30 of about 86,047 (385)

Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective

Epilepsia, 2020
Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital is currently the most widely used antiseizure drug for treatment of neonatal seizures, but
Marie Johne, Kerstin Römermann, Philip Hampel, Björn Gailus, W. Theilmann, T. Ala-Kurikka, K. Kaila, W. Löscher   +7 more
semanticscholar   +1 more source

Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats

Frontiers in Veterinary Science, 2020
Phenobarbital is a common drug used to manage epilepsy in goats. However, the recommended dose and dosing frequency are based on studies in dogs and horses.
Liana M. Yates, Monica Aleman, Heather K. Knych, Marguerite F. Knipe, Chelsea M. Crowe, Munashe Chigerwe   +5 more
doaj   +1 more source

Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022
Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and ...
Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh   +2 more
doaj   +1 more source

The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. [PDF]

PLoS ONE, 2014
Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO)
Marumi Ohno, Tomohiko Kanayama, Rick Moore, Manas Ray, Masahiko Negishi   +4 more
doaj   +1 more source

2015 ACVIM Small Animal Consensus Statement on Seizure Management in Dogs [PDF]

, 2016
This report represents a scientific and working clinical consensus statement on seizure management in dogs based on current literature and clinical expertise.
Bunch SE, Bunch SE, Cheuk DK, Cunningham JG, Dayrell‐Hart B, Durkes TE, Dyer KR, E.E. Patterson, Farnbach GC, Farnbach GC, Forrester SD, Frey HH, Gaskill CL, Gaskill CL, H.A. Volk, Jacobs G, Jennings PB, K. Muñana, Kantrowitz LB, M. Berendt, M. Podell, March PA, Masuda Y, Nichols ES, Patterson E, Pearce L, Pedersoli WM, Perrucca E, Poffenbarger EM, Ravis WR, S.R. Platt, Schwartz‐Porsche D, Schwartz‐Porsche D, Steinberg M, Thurman GD, Trepanier LA, Trepanier LA, W. Löscher   +37 more
core   +2 more sources

Suspected phenobarbital-induced pancytopenia in a cat

Journal of Feline Medicine and Surgery Open Reports, 2020
Case summary A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures.
Maria Lyraki, Helen Wilson
doaj   +1 more source

Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]

, 2016
Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M., Kraft, Walter K., Stover, Megan W.   +2 more
core   +2 more sources

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

C45 - Hydrogels oraux pH-sensibles contenant du phénobarbital pour une utilisation potentielle en pédiatrie

Journal Africain de Technologie Pharmaceutique et Biopharmacie, 2023
Introduction : Le but de l’étude était de développer des hydrogels oraux à base de chitosane pH- sensibles, capables de libérer le phénobarbital dans l'intestin grêle du nouveau-né.
Alphonse Rodrigue DJIBOUNE, Nicolas Anton, Sidy Mouhamed Dieng, Papa Mady Sy, Diouf Diouf, Gora Mbaye, Mamadou Soumboundou, Said Ennahar, Nadia Messaddeq, Thierry Vandamme, Mounibe Diarra   +10 more
doaj   +1 more source

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. [PDF]

, 2013
In a previous study we had shown that treatment of male Fischer rats with exogenous chemicals for three months resulted in prominent, mode-of-action dependent effects on liver microRNA (miRNA) (Koufaris et al., 2012). Here we investigated how the effects
Currie, RA, Gooderham, NJ, Koufaris, C, Osborne, M, Wright, J   +4 more
core   +1 more source