Interventions for treating hyperemesis gravidarum. [PDF]
, 2016 BACKGROUND: Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0.3% to 1.0% of pregnancies, and is one of the most common indications for hospitalization during pregnancy.
Abas +96 more
core +2 more sources
Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital.
Biological and Pharmaceutical Bulletin, 1997 Molecularly imprinted polymer (MIP) was prepared against phenobarbital using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross linking monomer. We analyzed the recognition properties of the phenobarbital MIP. In some organic solvents, imprinted polymer showed selective binding to phenobarbital.
Masahiro Niizeki +6 more
openaire +4 more sources
Ciradian dysrhythmias in the EEG of children with clonazepam treatment [PDF]
, 1984 The effects of different anticonvulsants on the system of cir-cadian and ultradian rhythms in the EEG of children was investigated in ten 24*-h recordings of children with different forms of epilepsy.
Arbogast, B. +4 more
core +1 more source
MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]
PLoS ONE, 2012 Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu +3 more
doaj +1 more source
Phenobarbital: missing in action
Bulletin of the World Health Organization, 2012 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries.1 Approximately 85% of these people do not receive appropriate treatment2 because of economic, cultural, social and legislative barriers, compounded by little interest on the part of pharmaceutical companies because drug distribution is not ...
Neshan B Ilangaratne +3 more
openaire +3 more sources
Phenobarbital Pharmacokinetics and Optimal Dosing of Phenobarbital
Pediatric Neurology Briefs, 2018 Researchers from the Baylor College of Medicine in Houston, TX, USA, conducted a retrospective population pharmacokinetic analysis of 355 patients ages less than 19 years of age in the inpatient setting who were initiated on intravenous or oral ...
Safiullah Shareef, Murtaza Nasir Ali
doaj +1 more source
Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. [PDF]
, 2008 The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification.
Finn, Robert +3 more
core +4 more sources
Standard Error of Empirical Bayes Estimate in NONMEM® VI. [PDF]
, 2012 The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and
Bae, Kyun-Seop +4 more
core +2 more sources
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria
BMC Pediatrics, 2019 Background Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy ...
Gretchen L. Birbeck +10 more
doaj +1 more source
Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure [PDF]
, 2010 Background: The development of effective therapies for acute liver failure (ALF) is limited by our knowledge of the pathophysiology of this condition, and the lack of suitable large animal models of acetaminophen toxicity.
A Francavilla +37 more
core +4 more sources