Results 31 to 40 of about 86,047 (385)

Oral Loading of Phenobarbital to Achieve Therapeutic Effects in Pediatric Patients with Acute Repetitive Seizures [PDF]

Annals of Child Neurology, 2023
Purpose Intravenous phenobarbital has not been available at our institution since 2019. This study aimed to determine the effectiveness of oral phenobarbital loading at a dose of 15 to 20 mg/kg to achieve therapeutic serum levels and clinical seizure ...
Jemima Grace D. Fronda, Mel Michel G. Villaluz, Cristina M. Cruz-Urbi   +2 more
doaj   +1 more source

Comparing the effect of intermittent diazepam and continuous phenobarbital in preventing recurrent febrile seizures among children under 6 years old: A systematic review and meta-analysis

Journal of Research in Medical Sciences, 2023
Background: Febrile convulsion (FC) is the most common and preventable seizure in children. This study aimed to assess the effectiveness of the diazepam and phenobarbital for preventing recurrent FC. Materials and Methods: In this systematic review study,
Leili Faraji Gavgani, Delara Laghousi, Parvin Sarbakhsh, Leila Jahangiri, Nafiseh Vahed, Sakineh Hajebrahimi   +5 more
doaj   +1 more source

Ciradian dysrhythmias in the EEG of children with clonazepam treatment [PDF]

, 1984
The effects of different anticonvulsants on the system of cir-cadian and ultradian rhythms in the EEG of children was investigated in ten 24*-h recordings of children with different forms of epilepsy.
Arbogast, B., Arbogast, Helmut, Hallek, M., Hellbrügge, T., Schmid, R.   +4 more
core   +1 more source

Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

Neonatology, 2019
Background: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450
Laurent M A Favié, F. Groenendaal, M. V. D. van den Broek, C. Rademaker, T. D. de Haan, Henrica L. M. van Straaten, P. Dijk, A. V. van Heijst, S. Simons, K. Dijkman, M. Rijken, I. Zonnenberg, F. Cools, A. Zecic, J. H. van der Lee, D. Nuytemans, F. van Bel, T. Egberts, A. Huitema   +18 more
semanticscholar   +1 more source

Revisiting phenobarbital for epilepsy [PDF]

BMJ, 2004
A recent review of phenobarbital for the treatment of epilepsy draws attention to an ethical dilemma and to the many gaps in our knowledge about a drug that has been in use since 1912.1 Phenobarbital is commonly prescribed in the developing world, but in most developed countries it has fallen into disrepute.
PERUCCA, EMILIO, Kale R.
openaire   +4 more sources

Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury

Acta Medica Iranica, 2022
Phenobarbital is still one of the drugs of choice in managing patients with brain injury in the intensive care unit (ICU). However, the impact of acute physiological changes on phenobarbital pharmacokinetic parameters is not well studied.
Seyedeh Sana Khezrnia, Bita Shahrami, Mohammad Reza Rouini, Atabak Najafi, Hamid Reza Sharifnia, Sima Sadrai, Arezoo Ahmadi, Aarefeh Jafarzadeh kohneloo, Farhad Najmeddin, Mojtaba Mojtahedzadeh   +9 more
doaj   +1 more source

Treatment of Alcohol Withdrawal Syndrome: Phenobarbital vs CIWA‐Ar Protocol

American Journal of Critical Care, 2018
Background Benzodiazepine‐based therapy for alcohol withdrawal is associated with agitation and respiratory depression. Treatment can be complicated by a need for adjunctive therapy to control these symptoms and in patients requiring mechanical ...
W. Tidwell, Tonya L Thomas, J. Pouliot, A. Canonico, Angus J Webber   +4 more
semanticscholar   +1 more source

Comparison between the Amount of Environmental Change and the Amount of Transcriptome Change.

PLoS ONE, 2015
Cells must coordinate adjustments in genome expression to accommodate changes in their environment. We hypothesized that the amount of transcriptome change is proportional to the amount of environmental change.
Norichika Ogata, Toshinori Kozaki, Takeshi Yokoyama, Tamako Hata, Kikuo Iwabuchi   +4 more
doaj   +1 more source

Phenobarbital-induced autoimmune haemolytic anaemia, thrombocytopenia and peripheral lymphadenomegaly due to reactive lymphoid hyperplasia in a cat

Journal of Feline Medicine and Surgery Open Reports, 2022
Case summary A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy.
Michelle Walton-Clark, Victoria Travail, Matthew Best   +2 more
doaj   +1 more source

Evading Seizures: Phenobarbital Reintroduced as a Multifunctional Approach to End-of-Life Care

Case Reports in Oncology, 2022
The selected case study aimed to evaluate the role of phenobarbital as a drug of choice in end-of-life (EOL) settings. Phenobarbital is efficacious in management of EOL seizures and agitation, can be easily administered via different modes, and utilized ...
Helen Senderovich, Sarah Waicus, Keisa Mokenela   +2 more
doaj   +1 more source