Results 31 to 40 of about 55,451 (338)
Epilepsia Open, 2021 Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley +6 more
doaj +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2022 The aim of this study was to analyze the behavior and histopathological changes in the hippocampus of epileptic Wistar rats treated with acupuncture associated or not with phenobarbital.
T.C.C. Silva +4 more
doaj +1 more source
In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System [PDF]
, 2002 Background/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure.
Bellomo, Rinaldo +10 more
core +1 more source
Phenobarbital Molecularly Imprinted Polymer Selectively Binds Phenobarbital.
Biological and Pharmaceutical Bulletin, 1997 Molecularly imprinted polymer (MIP) was prepared against phenobarbital using methacrylic acid as the functional monomer and ethylene glycol dimethacrylate as the cross linking monomer. We analyzed the recognition properties of the phenobarbital MIP. In some organic solvents, imprinted polymer showed selective binding to phenobarbital.
Masahiro Niizeki +6 more
openaire +4 more sources
MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]
PLoS ONE, 2012 Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu +3 more
doaj +1 more source
Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. [PDF]
, 2013 In a previous study we had shown that treatment of male Fischer rats with exogenous chemicals for three months resulted in prominent, mode-of-action dependent effects on liver microRNA (miRNA) (Koufaris et al., 2012). Here we investigated how the effects
Currie, RA +4 more
core +1 more source
Phenobarbital: missing in action
Bulletin of the World Health Organization, 2012 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries.1 Approximately 85% of these people do not receive appropriate treatment2 because of economic, cultural, social and legislative barriers, compounded by little interest on the part of pharmaceutical companies because drug distribution is not ...
Neshan B Ilangaratne +3 more
openaire +3 more sources
Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience [PDF]
, 2019 BACKGROUND: Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures. More recently, levetiracetam (LEV) has been increasingly used as a promising newer antiepileptic medication for treatment of seizures in ...
Barbagallo, M. +7 more
core +3 more sources
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria
BMC Pediatrics, 2019 Background Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy ...
Gretchen L. Birbeck +10 more
doaj +1 more source
Microbial Metabolism and Inhibition Studies of Phenobarbital [PDF]
, 2012 Purpose: Screening scale studies were performed with eight cultures for their ability to metabolize phenobarbital, an antiepileptic, sedative, hypnotic and substrate for CYP 2C9 and 2C19.Methods: The transformation of phenobarbital was confirmed and ...
Asha, S +3 more
core +2 more sources