Results 131 to 140 of about 3,784 (223)

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Frontiers in Neurology, 2018
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors.
Matej Skorvanek, Matej Skorvanek, Eva Feketeova, Eva Feketeova, Monica M. Kurtis, Jan Rusz, Jan Rusz, Karel Sonka   +7 more
doaj   +1 more source

Differential subcellular expression of ^P525L FUS as a putative biomarker for ALS phenoconversion [PDF]

, 2020
Maria Caputo, Vincenzo La Bella, Antonietta Notaro   +2 more
openalex   +1 more source

Design of a randomized, placebo-controlled, Phase 3 trial of tofersen initiated in clinically presymptomatic SOD1 variant carriers: The ATLAS study [PDF]

, 2022
Despite extensive research, amyotrophic lateral sclerosis (ALS) remains a progressive and invariably fatal neurodegenerative disease. Limited knowledge of the underlying causes of ALS has made it difficult to target upstream biological mechanisms of ...
Benatar, Michael, Bucelli, Robert C, et al.,   +2 more
core   +1 more source

Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism [PDF]

, 2021
Malavika Deodhar, Jacques Turgeon, Véronique Michaud   +2 more
openalex   +1 more source

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
doaj   +1 more source

Pharmacogenomics in Psychiatry – the Challenge of Cytochrome P450 Enzyme Phenoconversion and Solutions to Assist Precision Dosing

, 2022
Sam Mostafa, Thomas M. Polasek, Chad Bousman, Daniel Mueller, Leslie J. Sheffield, Joel Rembach, Carl M. J. Kirkpatrick   +6 more
openalex   +1 more source

Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation [PDF]

Анналы клинической и экспериментальной неврологии
This review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease.
Diana M. Khasanova, Zuleykha A. Zalyalova, Guzal R. Ilina, Nailya I. Bagdanova   +3 more
doaj   +1 more source

Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

Clinical Parkinsonism & Related Disorders
Introduction: This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia ...
Tomoyuki Miyamoto, Itsuo Nakajima, Takuo Arikawa, Masayuki Miyamoto   +3 more
doaj   +1 more source

Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease

Frontiers in Neurology, 2015
We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer’s disease (LOAD). A ten plasma lipid panel, predicted phenoconversion and provided 90% sensitivity and 85% specificity in differentiating an at-risk group from those ...
Massimo S Fiandaca, Xioagang eZhong, Amrita K Cheema, Michael H. Orquiza, Swathi eChidambaram, Ming T Tan, Carole Roan Gresenz, Kevin T FitzGerald, Michael A Nalls, Andrew B Singleton, Mark eMapstone, Howard J Federoff   +11 more
doaj   +1 more source

Integrating Pharmacogenomic Results and Drug-Induced Phenoconversion Concepts while Conducting a Medication Safety Review Process [PDF]

, 2022
Katie Pizzolato
openalex   +1 more source