Results 151 to 160 of about 3,784 (223)

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Acta Neuropathologica Communications
A link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates that the presynaptic neuronal protein alpha-synuclein (asyn) is closely tied to PD pathogenesis.
Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis   +10 more
doaj   +1 more source

Preclinical and Prodromal Frontotemporal Dementia: Challenges and Opportunities

International Journal of Translational Medicine
Frontotemporal lobar degeneration (FTLD) represents a heterogeneous group of neurodegenerative disorders with overlapping clinical, pathological, and genetic characteristics.
Federica Palacino, Paolo Manganotti, Alberto Benussi   +2 more
doaj   +1 more source

Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson’s disease

, 2022
Cameron Miller‐Patterson, Jesse Y. Hsu, Lana M. Chahine, James F. Morley, Allison W. Willis   +4 more
openalex   +2 more sources

Huntington disease: natural history, biomarkers and prospects for therapeutics [PDF]

, 2014
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is caused by a single genetic mutation and is amenable to predictive genetic testing, with estimation of years to predicted onset, enabling the entire range of disease ...
Aylward, EH, Langbehn, DR, Leavitt, BR, Long, JD, Margolis, RL, Paulsen, JS, Reilmann, R, Ross, CA, Scahill, RI, Stout, JC, Tabrizi, SJ, Unschuld, PG, Warner, JH, Wexler, A, Wild, EJ   +14 more
core  

Pharmacogenetic CYP2D6 variability, phenoconversion and treatment outcomes: A Danish population-based cohort study in 6,798 individuals initiating atomoxetine treatment [PDF]

, 2022
Kazi Ishtiak‐Ahmed, C. Lunenburg, J. Thirstrup, Loa Clausen, P. Thomsen, Christiane Gasse   +5 more
openalex   +1 more source

Human liver degradation of 5-fluorouracil: endogenous uracil may result in phenoconversion of dihydropyrimidine dehydrogenase activity

, 2018
Nuala A. Helsby, Kathryn Burns, Brent C. McGillivray, Liam Andrews, Malcolm D. Tingle   +4 more
openalex   +2 more sources

Blood will tell: plasma biomarkers in isolated REM sleep behavior disorder. [PDF]

Sleep
Ibrahim A, Süzgün MA, Stefani A.
europepmc   +1 more source

Cholinergic degeneration in prodromal and early Parkinson's disease: a link to present and future disease states. [PDF]

Brain
Eisenstein T, Groenewald K, van Hillegondsberg L, Al Hajraf F, Zerenner T, Lawton MA, Ben-Shlomo Y, Griffanti L, Hu MT, Klein JC.   +9 more
europepmc   +1 more source

544 Unlocking Midazolam’s Potential as a Biomarker for CYP3A4 Phenoconversion in Pediatric Burn and Surgery Patients [PDF]

Vincent Basas, Kristin Grimsrud, Emma Sherman, Tina L. Palmieri   +3 more
openalex   +1 more source

Design considerations for C9orf72 disease prevention trials. [PDF]

Brain
Benatar M, Staffaroni AM, Wuu J, McDermott MP, Quintana M, Swidler J, Andersen G, Huey ED, Turner MR, Macklin EA, Berry JD, McMillan CT, Gendron T, Onyike C, Rosen H, Heuer HW, Grignon AL, Dave KD, Balas C, Gleixner A, Satlin A, Dunn B, Dacks P, Boxer AL.   +23 more
europepmc   +1 more source