Results 61 to 70 of about 423,278 (305)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Application of a Cold-Pressing Treatment to Improve Virgin Olive Oil Production and the Antioxidant Phenolic Profile of Its by-Products

open access: yesAntioxidants, 2023
The olive oil sector is continuously evolving in order to improve the quality of olive oil and its by-products. In fact, the trend is to use increasingly greener olives to improve quality by decreasing the extraction yield, thus obtaining a higher ...
África Fernández-Prior   +5 more
doaj   +1 more source

THE DETERMINATION OF PHENOL. [PDF]

open access: yesJournal of the American Chemical Society, 1905
n ...
openaire   +1 more source

Thermal properties and thermal degradation kinetics of phenolic and wood flour-reinforced phenolic foams

open access: yes, 2017
In the present work, the thermal stability, changes in chemical structure during thermal degradation, and the kinetics of thermal degradation of a phenolic foam were studied.
Del Saz-Orozco, Belén   +4 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Stimulation of Armillaria mellea by phenolic fungicides

open access: yes, 2002
Phenolic fungicides, which were initially fungicidal to mycelium of Armillaria mellea on the surface of well-colonised wood billets, eventually stimulated the growth of A. mellea. An extensive growth of rhizomorphs was produced from A.
Fox, R. T. V., West, J. S.
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

open access: yesFEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton   +6 more
wiley   +1 more source

CHEMICAL COMPOSITION, VOLATILES, AND ANTIOXIDANT ACTIVITY OF Rosa iberica STEV. hips

open access: yesActa Scientiarum Polonorum: Hortorum Cultus, 2016
. Rosehip fruits have been known to contain significant amounts of bioactive compounds. These bioactive compounds positively affect human health due to their antioxidant activities.
Zehra Tuğba Abaci   +3 more
doaj  

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