Results 41 to 50 of about 229,486 (268)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Subcritical Water Technology for Extraction of Phenolic Compounds from Chlorella sp. Microalgae and Assessment on Its Antioxidant Activity

Molecules, 2017
Chlorella sp. microalgae is a potential source of antioxidants and natural bioactive compounds used in the food and pharmaceutical industries. In this study, a subcritical water (SW) technology was applied to determine the phenolic content and ...
Siti Maisurah Zakaria, Siti Mazlina Mustapa Kamal, Mohd Razif Harun, Rozita Omar, Shamsul Izhar Siajam   +4 more
doaj   +1 more source

Vitamin B complex, amino acid profile and bioactive properties of newly developed rye variants

International Journal of Food Properties, 2023
This study was designed to investigate the amino acid profile, vitamin B complex, and bioactive properties present in recently cultivated rye variants in Pakistan.
Ali Ikram, Farhan Saeed, Muhammad Afzaal, Javed Iqbal, Mohamed Hassan Mohamed   +4 more
doaj   +1 more source

THE DETERMINATION OF PHENOL. [PDF]

Journal of the American Chemical Society, 1905
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openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Grazer Functional Roles, Induced Defenses, and Indirect Interactions: Implications for Eelgrass Restoration in San Francisco Bay

Diversity, 2014
Understanding the individual and interactive roles of consumer species is more than academic when the host plant is a subject of intense conservation interest.
Jeffrey T. Lewis, Katharyn E. Boyer
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Comparative Study on Antioxidant and Antibacterial Activities of Four Senecio Species From Turkey

International Journal of Secondary Metabolite, 2015
The present study was conducted to investigate total phenolic content, antioxidant and antibacterial activity of four Senecio L. (Asteraceae). The in vitro antioxidant activities of extracts were evaluated with different antioxidant testing systems ...
Sevil ALBAYRAK, Ahmet AKSOY, Lutfiye YURTSEVEN, Abit YAŞAR   +3 more
doaj  

Molecular genetic analysis of gene pools of rare and endangered plant species Adonis L. of Northern Kazakhstan [PDF]

Caspian Journal of Environmental Sciences
Adonis L. is one of the largest and most famous genera of the Runanculaceae family. Adonis genus includes two parts of annual and perennial species.
Moldir Zhumagul, Anar Myrzagaliyeva, Saule Mukhtubayeva, Saule Baibossynova, Ainur Zhanbyrbayeva, Kairat Akhmetov, Assel Rustemova, Assemgul Bekturova   +7 more
doaj   +1 more source