Results 321 to 330 of about 3,642,031 (384)

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Transformations of phenolic compounds in cocoa shell during in vitro colonic fermentation. [PDF]

Curr Res Food Sci
Cañas S, Tosi N, Núñez-Gómez V, Del Rio D, Mena P, Aguilera Y, Martín-Cabrejas MA.   +6 more
europepmc   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Grape Pomace: A Review of Its Bioactive Phenolic Compounds, Health Benefits, and Applications. [PDF]

Molecules
Lopes JDC, Madureira J, Margaça FMA, Cabo Verde S.   +3 more
europepmc   +1 more source

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science, EarlyView.
A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
wiley   +1 more source

Quantification of Phenolic Compounds in Olive Oils by Near-Infrared Spectroscopy and Multiple Regression: Effects of Cultivar, Hydroxytyrosol Supplementation, and Deep-Frying. [PDF]

Antioxidants (Basel)
Mehany T, González-Sáiz JM, Pizarro C.
europepmc   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

Oxidation of Small Phenolic Compounds by Mn(IV). [PDF]

Molecules
Gruenberg MG, Halvorson JJ, Hagerman AE, Enoma IG, Schmidt MA.   +4 more
europepmc   +1 more source

Discovery of Novel Phenolic Compounds from <i>Eutypa lata</i> Through OSMAC Approach: Structural Elucidation and Antibiotic Potential. [PDF]

Int J Mol Sci
Cotán A, Izquierdo-Bueno I, Ezzanad A, Martín L, Delgado M, Collado IG, Pinedo-Rivilla C.   +6 more
europepmc   +1 more source

Antimicrobial, Anti-Biofilm Activity and Antioxidants of Phenolic Compounds Isolated From <i>Hypericum perforatum</i> on Periodontal Pathogenic Oral Bacteria. [PDF]

Food Sci Nutr
Al-Haliem SM, Mohammed MJ, Hesarinejad MA, Abedelmaksoud TG.   +3 more
europepmc   +1 more source