Results 51 to 60 of about 5,927,439 (276)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Methods of Assertion in the Tafsīr Abi al-Sa'ud= أسلوب التوكيد في تفسير أبي السعود
Journal of Islamic and Religious Studies, 2018 The concept of assertion has been playing a vital role in the linguistic to specify the meaning and nullify the uncertainties from the sentences. The numerous uses of assertion and its tools in Arabic language also played very significant role in ...
Yahya Khan, Dr. Hafizatullah al-Hafiz
doaj +1 more source
Time in Sergey Trubetskoy’s and Boris Chicherin’s metaphysical concepts: A discussion on Kant [PDF]
Кантовский сборник, 2017 This article analyses the controversy between Sergey Trubetskoy and Boris Chicherin, which followed the publication of Trubetskoy’s monograph the Foundations of Idealism. This analysis focuses on the philosophers’ understanding of the metaphysical nature
Savntisev V. I.
doaj +1 more source
The pan-African banks phenomenon [PDF]
, 2015 One of the key reasons these banks are becoming quite successful and important in the African continent is that they target market segments out of the purview of those global banks that have a foothold in the region.https://www.researchgate.net ...
Goncalves, Marcus
core
Nonequilibrium Goldstone phenomenon in Hybrid Inflation
, 2003 We study the onset of Goldstone phenomenon in a hybrid inflation scenario. The physically motivated range of parameters is analyzed in order to meet the cosmological constraints.
Borsanyi, Sz., Patkos, A., Sexty, D.
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Digital Innovation: The Hackathon Phenomenon [PDF]
, 2014 date-added: 2015-03-24 04:16:59 +0000 date-modified: 2015-03-24 04:16:59 +0000date-added: 2015-03-24 04:16:59 +0000 date-modified: 2015-03-24 04:16:59 +0000This work was supported by the Arts and Humanities Research Council, CreativeWorks London Hub ...
Briscoe, G
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source