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Phenothiazines enhance antibacterial activity of macrophage by inducing ROS and autophagy [PDF]
Frontiers in ImmunologyBacterial infections pose a major global public health threat. While antibiotics have historically served as the primary treatment, the rapid rise of antibiotic resistance has led to an urgent need for new therapeutic strategies. Host-directed therapies (
Lihao Qiu +5 more
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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells [PDF]
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
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Life, 2021 Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its ...
Michał Otręba +3 more
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Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
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Antibiotics, 2022 Persistent apical periodontitis occurs when the endodontic treatment fails to eradicate the intraradicular infection, and is mainly caused by Gram-positive bacteria and yeasts, such as Enterococcus faecalis and Candida albicans, respectively ...
Nicole de Mello Fiallos +7 more
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Molecules, 2021 Phenothiazines are known as synthetic antipsychotic drugs that exhibit a wide range of biological effects. Their properties result from the structure and variability of substituents in the heterocyclic system.
Andrzej Poła +2 more
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Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli
Toxins, 2021 Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties.
John K. Crane +2 more
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14-Substituted Diquinothiazines as a New Group of Anticancer Agents
Molecules, 2023 A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell lines
Małgorzata Jeleń +7 more
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Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450 [PDF]
Vojnosanitetski Pregled, 2021 Introduction. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of various drugs and chemicals. The forensic pathologist should consider not only pharmacodynamic interactions by multiple drugs but also the pharmacokinetic drug interactions
Kinoshita Hiroshi +6 more
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Chemosensors, 2022 Array-based optical sensing is an efficient technique for the determination and discrimination of small organic molecules. This study is aimed at the development of a simple and rapid strategy for obtaining an optical response from a wide range of low ...
Anna V. Shik +4 more
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