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Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells [PDF]
Frontiers in Oncology, 2023 The limitations of current cancer therapies, including the increasing prevalence of multidrug resistance, underscore the urgency for more effective treatments. One promising avenue lies in the repurposing of existing drugs.
Syrina Fred Mehrabi +3 more
doaj +3 more sources
Antibiotics, 2013 Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and ...
Leonard Amaral, A Salvucci
exaly +4 more sources
Phenothiazines and their Evolving Roles in Clinical Practice: A Narrative Review
Health Psychology Research, 2022 Phenothiazines, a diverse class of drugs, can be used to treat multiple mental health and physical conditions. Phenothiazines have been used for decades to treat mental illnesses, including schizophrenia, mania in bipolar disorder, and psychosis ...
Amber N. Edinoff +8 more
doaj +2 more sources
Possible Biological and Clinical Applications of Phenothiazines
Anticancer Research, 2017 Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology. These compounds are able to effectively inhibit dopamine, histamine, serotonin, acetylcholine, and α-adrenergic receptors; thus, their effect and side-effect profiles ...
Leonard Amaral, Gabriella Spengler
exaly +2 more sources
Type IV Pilus-Mediated Inhibition of Acinetobacter baumannii Biofilm Formation by Phenothiazine Compounds [PDF]
Microbiology Spectrum, 2023 Infections by pathogenic Acinetobacter species represent a significant burden on the health care system, despite their relative rarity, due to the difficulty of treating infections through oral antibiotics.
Nam Vo +3 more
doaj +2 more sources
Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein [PDF]
Viruses, 2023 Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence ...
Taizhen Liang +8 more
doaj +2 more sources
Cell Death and Disease, 2014 Phenothiazines are a family of heterocyclic compounds whose clinical utility includes treatment of psychiatric disorders as well as chemotherapy-induced emesis.
D. Zong +6 more
exaly +2 more sources
Antitubercular pharmacodynamics of phenothiazines [PDF]
Journal of Antimicrobial Chemotherapy, 2012 Phenothiazines have been shown to exhibit in vitro and in vivo activity against Mycobacterium tuberculosis (Mtb) and multidrug-resistant Mtb. They are predicted to target the genetically validated respiratory chain component type II NADH:quinone oxidoreductase (Ndh).
Neil G. Berry +7 more
openaire +4 more sources