UV-light effects on cytochrome c modulated by the aggregation state of phenothiazines. [PDF]
PLoS ONE, 2013 The present study shows the factors that modulate the photodamage promoted by phenothiazines. Cytochrome c was irradiated with UV light for 120 min, over a pH range from 4.0 to 8.0, in the absence and in the presence of different concentrations of ...
Carolina G dos Santos +7 more
doaj +1 more source
Phenothiazine Derivatives and Their Impact on the Apoptosis Processes: A Review. [PDF]
J Appl ToxicolABSTRACT Phenothiazine derivatives have been used for decades as antipsychotic drugs in multiple mental health and physical conditions treatment (schizophrenia, mania in bipolar disorder, and psychosis). Epidemiological studies have shown that people with schizophrenia are less likely to suffer from cancer, which indicates the ability of antipsychotics
Otręba M +4 more
europepmc +2 more sources
Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer. [PDF]
, 2014 Somatic mutations of the epidermal growth factor receptor often cause resistance to therapy with tyrosine kinase inhibitor in non-small cell lung cancer (NSCLC). In this study, we aimed to identify partner drugs and pathways that can induce cell death in
Koeffler, H Phillip +5 more
core +2 more sources
Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine [PDF]
, 2011 The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small ...
Asif Husain Naqvi +4 more
core +2 more sources
Frontiers in Microbiology, 2020 Calcium ions (Ca2+) play a pivotal role in eukaryote cell signaling and regulate many physiological functions. Although a similar role for Ca2+ in prokaryotes has been difficult to demonstrate, there is increasing evidence for Ca2+ as a cell regulator in
Amy R. Nava +4 more
doaj +1 more source
Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present [PDF]
, 2015 Historically, multiplicity of actions in synthetic compounds is a rule rather than exception. The science of non-antibiotics evolved in this background.
Debalina Sinha Roy +6 more
core +7 more sources
Synthesis of Bioactive Fluorinated 10H-Phenothiazines and their Sulfone Derivatives
E-Journal of Chemistry, 2008 The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide.
Yogesh Dixit +3 more
doaj +1 more source
N -haloacetyl phenothiazines and derivatives: Preparation, characterization and structure-activity relationship for antifungal activity [PDF]
, 2017 A serie of N-acetyl phenothiazines and related compounds was synthesized by means of the acetylation reaction of the corresponding phenothiazine with the appropriate reagent using microwave irradiation.
Afeltra, Javier +7 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Antibiotics, 2013 Phenothiazines have their primary effects on the plasma membranes of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources and energy providing enzymes, such as ATPase, and ...
Leonard Amaral +3 more
doaj +1 more source