Results 11 to 20 of about 29,628 (301)
Life, 2021 Small molecules are routinely used to inhibit protein kinases, but modulators capable of enhancing kinase activity are rare. We have previously shown that the small molecule INR119, designed as an inhibitor of MEK1/2, will enhance the activity of its ...
Michał Otręba +3 more
doaj +1 more source
Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
doaj +1 more source
Phenothiazines Modified with the Pyridine Ring as Promising Anticancer Agents
Life, 2021 Azaphenothiazines are the largest and most perspective group of modified phenothiazines, and they exhibit variety of biological activities. The review sums up the current knowledge on the anticancer activity of isomeric pyridobenzothiazines and ...
Beata Morak-Młodawska +2 more
semanticscholar +1 more source
Antibiotics, 2022 Persistent apical periodontitis occurs when the endodontic treatment fails to eradicate the intraradicular infection, and is mainly caused by Gram-positive bacteria and yeasts, such as Enterococcus faecalis and Candida albicans, respectively ...
Nicole de Mello Fiallos +7 more
doaj +1 more source
Molecules, 2021 Phenothiazines are known as synthetic antipsychotic drugs that exhibit a wide range of biological effects. Their properties result from the structure and variability of substituents in the heterocyclic system.
Andrzej Poła +2 more
doaj +1 more source
Antifungal Structure–Activity Relationship Studies of Broad-Spectrum Phenothiazines [PDF]
ACS OmegaSamantha C. Brosend +11 more
doaj +2 more sources
14-Substituted Diquinothiazines as a New Group of Anticancer Agents
Molecules, 2023 A series of novel double-angularly condensed diquinothiazines with aminoalkyl, amidoalkyl, sulfonamidoalkyl, and substituted phenyl groups was designed, synthesized, and evaluated for their anticancer activity against four selected human tumor cell lines
Małgorzata Jeleń +7 more
doaj +1 more source
Psychoactive Drugs Induce the SOS Response and Shiga Toxin Production in Escherichia coli
Toxins, 2021 Several classes of non-antibiotic drugs, including psychoactive drugs, proton-pump inhibitors (PPIs), non-steroidal anti-inflammatory drugs (NSAIDs), and others, appear to have strong antimicrobial properties.
John K. Crane +2 more
doaj +1 more source
Phenothiazines and the electrocardiogram [PDF]
Postgraduate Medical Journal, 1975 Summary Fifty-nine (42%) of 140 schizophrenic patients taking phenothiazines were found to have abnormal electrocardiograms. The abnormalities included T wave changes, S-T depression, P-R and Q-T prolongation, persistent sinus tachycardia (110 or more/min) and right bundle branch block.
R. Benson, M. V. Jeeva Raj
openaire +2 more sources
UV-light effects on cytochrome c modulated by the aggregation state of phenothiazines. [PDF]
PLoS ONE, 2013 The present study shows the factors that modulate the photodamage promoted by phenothiazines. Cytochrome c was irradiated with UV light for 120 min, over a pH range from 4.0 to 8.0, in the absence and in the presence of different concentrations of ...
Carolina G dos Santos +7 more
doaj +1 more source