Results 21 to 30 of about 36,717 (342)
Frontiers in Microbiology, 2020 Calcium ions (Ca2+) play a pivotal role in eukaryote cell signaling and regulate many physiological functions. Although a similar role for Ca2+ in prokaryotes has been difficult to demonstrate, there is increasing evidence for Ca2+ as a cell regulator in
Amy R. Nava +4 more
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Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450 [PDF]
Vojnosanitetski Pregled, 2021 Introduction. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of various drugs and chemicals. The forensic pathologist should consider not only pharmacodynamic interactions by multiple drugs but also the pharmacokinetic drug interactions
Kinoshita Hiroshi +6 more
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ACS Omega, 2020 The green and environmentally friendly synthesis of highly valuable organic substances is one possibility for the utilization of laccases (EC 1.10.3.2). As reactants for the herein described syntheses, different o-substituted arylamines or arylthiols and
V. Hahn +7 more
semanticscholar +1 more source
Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine [PDF]
, 2011 The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small ...
Asif Husain Naqvi +4 more
core +2 more sources
Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer. [PDF]
, 2014 Somatic mutations of the epidermal growth factor receptor often cause resistance to therapy with tyrosine kinase inhibitor in non-small cell lung cancer (NSCLC). In this study, we aimed to identify partner drugs and pathways that can induce cell death in
Koeffler, H Phillip +5 more
core +2 more sources
Frontiers in Chemistry, 2020 The study of proteins and mechanisms involved in the apoptosis and new knowledge about cancer's biology are essential for planning new drugs. Tumor cells develop several strategies to gain proliferative advantages, including molecular alterations to ...
Aline Lagoeiro do Carmo +7 more
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Simple and simultaneous determination for twelve phenothiazines in human serum by reversed-phase high-performance liquid chromatography [PDF]
, 2007 A high-performance liquid chromatographic method has been developed for the simultaneous analysis of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine,
Hashimoto Chikako +7 more
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Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates
, 2020 Novel synthetic methods for phenoxathiins and phenothiazines by aryne reactions are disclosed. We found that phenoxathiins were efficiently prepared by the reaction between aryne intermediates and ...
Kazuya Kanemoto +3 more
semanticscholar +1 more source
Synthesis of Bioactive Fluorinated 10H-Phenothiazines and their Sulfone Derivatives
E-Journal of Chemistry, 2008 The present communication deals with the synthesis of a series of fluorinated 10H-phenothiazines. 10H-phenothiazines is prepared by Smiles rearrangement of substituted 2-foramido-2´-nitrodiphenylsulfide.
Yogesh Dixit +3 more
doaj +1 more source
Molecular characterization of phenothiazines in experimental cancer therapy - New tricks of an old drug revealed [PDF]
, 2012 Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. Unfortunately, the efficacy of
Zong, Dali
core +1 more source