Results 31 to 40 of about 29,628 (301)

Pleiotropic actions of phenothiazine drugs are detrimental to Gram-negative bacterial persister cells

Communications Biology, 2022
Phenothiazines, which have previously been approved as antipsychotic drugs, can also reduce growth and metabolism in a range of Gram-negative bacterial pathogens.
Sayed Golam Mohiuddin, Thao Vy Nguyen, Mehmet A. Orman   +2 more
doaj   +1 more source

Do phenothiazines possess antimicrobial and efflux inhibitory properties?

FEMS Microbiology Reviews, 2019
Antibiotic resistance is a global health concern; the rise of drug-resistant bacterial infections is compromising the medical advances that resulted from the introduction of antibiotics at the beginning of the 20th century.
E. Grimsey, L. Piddock
semanticscholar   +1 more source

Stability Studies of UV Laser Irradiated Promethazine and Thioridazine after Exposure to Hypergravity Conditions

Molecules, 2022
Pharmaceuticals carried into space are subjected to different gravitational conditions. Hypergravity is encountered in the first stage, during spacecraft launching.
Ágota Simon, Tatiana Tozar, Adriana Smarandache, Mihai Boni, Alexandru Stoicu, Alan Dowson, Jack J. W. A. van Loon, Mihail Lucian Pascu   +7 more
doaj   +1 more source

The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells

International Journal of Molecular Sciences, 2019
Since none of the multidrug resistance (MDR) modulators tested so far found their way into clinic, a novel approach to overcome the MDR of cancer cells has been proposed.
K. Środa-Pomianek, K. Michalak, A. Palko-Łabuz, A. Uryga, P. Świątek, M. Majkowski, O. Wesołowska   +6 more
semanticscholar   +1 more source

Analytical Applications of Reactions of Iron(III) and Hexacyanoferrate(III) with 2,10-Disubstituted Phenothiazines

International Journal of Analytical Chemistry, 2009
The presented review is devoted to analytical applications of reactions of Fe(III) and K3[Fe(CN)6] with 2,10-disubstituted phenothiazines (PT). It was found that iron(III) and hexacyanoferrate(III) ions in acidic media easily oxidized PT with the ...
Helena Puzanowska-Tarasiewicz, Joanna Karpińska, Ludmiła Kuźmicka   +2 more
doaj   +1 more source

Synthesis and Structural Characterization of Novel Dimers of Dipyridothiazine as Promising Antiproliferative Agents

Molecules, 2023
Many new isomeric dipyridothiazine dimers have been presented as molecules with anticancer potential. These compounds were obtained in efficient syntheses of 1,6-, 1,8-, 2,7- and 3,6-diazaphenothiazines with selected alkylaromatic linkers. The structures
Emilia Martula, Beata Morak-Młodawska, Małgorzata Jeleń, Patrick N. Okechukwu, Abbirami Balachandran, Prethika Tehirunavukarasu, Kirthani Anamalay, Vaidehi Ulaganathan   +7 more
doaj   +1 more source

Docking and Biological Screening of Bezo[A]phenothiazinones as Novel Inhibitors of Bacterial Peptidogloycan Transpeptidase [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
Rising cases of antibiotic-resistant bacteria is a public health concern. Many approved antibiotics target penicillin-binding proteins example peptidoglycan transpeptidase (PTPase). Due to wide pharmacological activity of phenothiazines, new styryl, aryl,
Akachukwu E. Ibezim, Efeturi Onoabedje A., Kovo G. Akpomie   +2 more
doaj  

Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination

Chemistry Letters, 2018
A facile method for the synthesis of diverse phenothiazines has been achieved by direct thioamination of aryne intermediates with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular ...
Tsubasa Matsuzawa, Keisuke Uchida, S. Yoshida, T. Hosoya   +3 more
semanticscholar   +1 more source

Synthesis, electronic properties and self-assembly on Au{111} of thiolated (oligo)phenothiazines

Beilstein Journal of Organic Chemistry, 2010
(Oligo)phenothiazinyl thioacetates, synthesized by a one-pot sequence, are electrochemically oxidizable and highly fluorescent. SAMs can be readily formed from thiols prepared by in situ deprotection of the thioacetates in the presence of a gold-coated ...
Adam W. Franz, Svetlana Stoycheva, Michael Himmelhaus, Thomas J. J. Müller   +3 more
doaj   +1 more source

Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N′-Arylaminophenothiazines

Molecules, 2022
The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N′-arylaminophenothiazines and asymmetrical 3,7-di(N′-arylamino ...
Alena Khadieva, Mansur Rayanov, Ksenia Shibaeva, Alexandr Piskunov, Pavel Padnya, Ivan Stoikov   +5 more
doaj   +1 more source