Results 31 to 40 of about 36,717 (342)
N -haloacetyl phenothiazines and derivatives: Preparation, characterization and structure-activity relationship for antifungal activity [PDF]
A serie of N-acetyl phenothiazines and related compounds was synthesized by means of the acetylation reaction of the corresponding phenothiazine with the appropriate reagent using microwave irradiation.
Afeltra, Javier+7 more
core +1 more source
This mini-review summarizes the syntheses and functionalizations of dithieno[1,4]thiazines and bis[1]benzothieno[1,4]thiazines, both electron density-enriched congeners of phenothiazines with remarkable electronic properties.
Lars May, Thomas J. J. Müller
doaj +1 more source
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon+38 more
core +6 more sources
Do phenothiazines possess antimicrobial and efflux inhibitory properties?
Antibiotic resistance is a global health concern; the rise of drug-resistant bacterial infections is compromising the medical advances that resulted from the introduction of antibiotics at the beginning of the 20th century.
E. Grimsey, L. Piddock
semanticscholar +1 more source
Many new isomeric dipyridothiazine dimers have been presented as molecules with anticancer potential. These compounds were obtained in efficient syntheses of 1,6-, 1,8-, 2,7- and 3,6-diazaphenothiazines with selected alkylaromatic linkers. The structures
Emilia Martula+7 more
doaj +1 more source
Pharmaceuticals carried into space are subjected to different gravitational conditions. Hypergravity is encountered in the first stage, during spacecraft launching.
Ágota Simon+7 more
doaj +1 more source
Since none of the multidrug resistance (MDR) modulators tested so far found their way into clinic, a novel approach to overcome the MDR of cancer cells has been proposed.
K. Środa-Pomianek+6 more
semanticscholar +1 more source
Docking and Biological Screening of Bezo[A]phenothiazinones as Novel Inhibitors of Bacterial Peptidogloycan Transpeptidase [PDF]
Rising cases of antibiotic-resistant bacteria is a public health concern. Many approved antibiotics target penicillin-binding proteins example peptidoglycan transpeptidase (PTPase). Due to wide pharmacological activity of phenothiazines, new styryl, aryl,
Akachukwu E. Ibezim+2 more
doaj
Synthesis, electronic properties and self-assembly on Au{111} of thiolated (oligo)phenothiazines
(Oligo)phenothiazinyl thioacetates, synthesized by a one-pot sequence, are electrochemically oxidizable and highly fluorescent. SAMs can be readily formed from thiols prepared by in situ deprotection of the thioacetates in the presence of a gold-coated ...
Adam W. Franz+3 more
doaj +1 more source
Phenothiazines solution complexity - determination of pKa and solubility-pH profiles exhibiting sub-micellar aggregation at 25 and 37°C [PDF]
The ionization constants (pKa) and the pH-dependent solubility (log S-pH) of six phenothiazine derivatives (promazine hydrochloride, chlorpromazine hydrochloride, triflupromazine hydrochloride, fluphenazine dihydrochloride, perphenazine free base, and ...
Avdeef, Alex+4 more
core +1 more source