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Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis [PDF]

BMC Medicine, 2019
Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion.
WWARN K13 Genotype-Phenotype Study Group
doaj   +3 more sources

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes [PDF]

Annals of Applied Statistics 2010, Vol. 4, No. 1, 320-339, 2010
Causal inference approaches in systems genetics exploit quantitative trait loci (QTL) genotypes to infer causal relationships among phenotypes. The genetic architecture of each phenotype may be complex, and poorly estimated genetic architectures may compromise the inference of causal relationships among phenotypes.
Attie, Alan D., Keller, Mark P., Neto, Elias Chaibub, Yandell, Brian S.   +3 more
arxiv   +6 more sources

Comprehensive Detection of Genes Causing a Phenotype using Phenotype Sequencing and Pathway Analysis [PDF]

, 2013
Discovering all the genetic causes of a phenotype is an important goal in functional genomics. In this paper we combine an experimental design for multiple independent detections of the genetic causes of a phenotype, with a high-throughput sequencing ...
Gronenberg, Luisa, Harper, Marc, Lee, Christopher, Liao, James   +3 more
core   +20 more sources

The Paradox of Nuclear Lamins in Pathologies: Apparently Controversial Roles Explained by Tissue-Specific Mechanobiology

Cells, 2022
The nuclear lamina is a complex meshwork of intermediate filaments (lamins) that is located beneath the inner nuclear membrane and the surrounding nucleoplasm.
Enrica Urciuoli, Barbara Peruzzi
doaj   +1 more source

Sustained spike-specific IgG antibodies following CoronaVac (Sinovac) vaccination in sub-Saharan Africa, but increased breakthrough infections in baseline spike-naive individuals

Frontiers in Immunology, 2023
IntroductionThis study investigated the antibody responses to the inactivated COVID-19 vaccine, CoronaVac (Sinovac Biotech) in the African population to provide valuable insights into long-term immunity and breakthrough infections against SARS-CoV-2 in ...
Jackson Sembera, Claire Baine, Violet Ankunda, Joseph Ssebwana Katende, Joseph Ssebwana Katende, Gerald Kevin Oluka, Gerald Kevin Oluka, Christine Hermilia Akoli, Laban Kato, Geoffrey Odoch, Peter Ejou, Solomon Opio, Monica Musenero, The COVID-19 Immunoprofiling Team, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Pontiano Kaleebu, Jennifer Serwanga, Jennifer Serwanga   +18 more
doaj   +1 more source

Seroprevalence and durability of antibody responses to AstraZeneca vaccination in Ugandans with prior mild or asymptomatic COVID-19: implications for vaccine policy

Frontiers in Immunology, 2023
IntroductionThe duration and timing of immunity conferred by COVID-19 vaccination in sub-Saharan Africa are crucial for guiding pandemic policy interventions, but systematic data for this region is scarce.
Jennifer Serwanga, Jennifer Serwanga, Claire Baine, Susan Mugaba, Violet Ankunda, Betty Oliver Auma, Gerald Kevin Oluka, Gerald Kevin Oluka, Laban Kato, Isaac Kitabye, Jackson Sembera, Geoffrey Odoch, Peter Ejou, Amina Nalumansi, Ben Gombe, Monica Musenero, Pontiano Kaleebu, Pontiano Kaleebu, the COVID-19 Immunoprofiling Team, the COVID-19 Immunoprofiling Team, Christine Hermilia Akoli, Deus Mwesigwa, Ivan Ssali, Hellen Nantambi, Angela Namuyanja, Solomon Opio, Arthur Watelo Kalyebi, Joseph Ssebwana Katende   +27 more
doaj   +1 more source

Cytokine expression patterns in hospitalized children with Bordetella pertussis, Rhinovirus or co-infection

Scientific Reports, 2021
Mechanisms of interaction between Bordetella pertussis and other viral agents are yet to be fully explored. We studied the inflammatory cytokine expression patterns among children with both viral-bacterial infections.
Elisabetta Pandolfi, Nadia Panera, Anna Alisi, Emanuela Carloni, Luisa Russo, Ilaria Campagna, Caterina Rizzo, Carlo Concato, Giulia Linardos, Livia Piccioni, Sally Jackson, Alberto Villani, Fabio Midulla, Alberto E. Tozzi   +13 more
doaj   +1 more source

Optimisation and Validation of a conventional ELISA and cut-offs for detecting and quantifying anti-SARS-CoV-2 Spike, RBD, and Nucleoprotein IgG, IgM, and IgA antibodies in Uganda

Frontiers in Immunology, 2023
There is an urgent need for better immunoassays to measure antibody responses as part of immune-surveillance activities and to profile immunological responses to emerging SARS-CoV-2 variants.
Gerald Kevin Oluka, Gerald Kevin Oluka, Patricia Namubiru, Laban Kato, Violet Ankunda, Ben Gombe, Matthew Cotten, Matthew Cotten, The COVID-19 Immunoprofiling Team, The COVID-19 Immunoprofiling Team, Monica Musenero, Pontiano Kaleebu, Pontiano Kaleebu, Julie Fox, Jennifer Serwanga, Jennifer Serwanga, Claire Baine, Jackson Sembera, Susan Mugaba, Christine Hermilia Akoli, Geoffrey Odoch, Deus Mwesigwa, Peter Ejou, Joseph Ssebwana Katende   +23 more
doaj   +1 more source

Nasopharyngeal microbiota in hospitalized children with Bordetella pertussis and Rhinovirus infection

Scientific Reports, 2021
Despite great advances in describing Bordetella pertussis infection, the role of the host microbiota in pertussis pathogenesis remains unexplored. Indeed, the microbiota plays important role in defending against bacterial and viral respiratory infections.
A. E. Tozzi, F. Del Chierico, E. Pandolfi, S. Reddel, F. Gesualdo, S. Gardini, V. Guarrasi, L. Russo, I. Croci, I. Campagna, G. Linardos, C. Concato, A. Villani, L. Putignani   +13 more
doaj   +1 more source

Lamin A/C Mechanosensor Drives Tumor Cell Aggressiveness and Adhesion on Substrates With Tissue-Specific Elasticity

Frontiers in Cell and Developmental Biology, 2021
Besides its structural properties in the nucleoskeleton, Lamin A/C is a mechanosensor protein involved in perceiving the elasticity of the extracellular matrix.
Enrica Urciuoli, Valentina D’Oria, Stefania Petrini, Barbara Peruzzi   +3 more
doaj   +1 more source