Results 101 to 110 of about 2,545,958 (345)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Phenotypes, Genotypes and Gens [PDF]

, 1912
O. F. Cook
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Polysomnographic Phenotype of Positional Obstructive Sleep Apnea [PDF]

Journal of Rhinology
Background and Objectives Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by recurrent upper airway obstruction, leading to disrupted sleep and various health complications.
Jae-Seon Park, Young Bok Kim, Il Seok Park, Sun A Han, Sung Hun Kang, Kyung Chul Lee, Seok Jin Hong   +6 more
doaj   +1 more source

A Critical Examination of the Reputed Primary Influence of ABO Phenotype on Fertility and Sex Ratio [PDF]

, 1957
James Edwards
openalex   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Molecular basis of D-negative phenotype (literature review and case reports)

Онкогематология, 2015
The molecular basis of the D-negative phenotype formation in humans is presented in this article. Causes of true and false D-negative phenotype appearance are described.
L. L. Golovkina, A. G. Stremouchova, T. D. Pushkina, B. B. Khasigova, G. V. Atroshchenko, M. N. Vasilyeva, R. S. Kalandarov, E. N. Parovichnikova   +7 more
doaj   +1 more source

Rh Phenotypes and Fisher's CDE Notation [PDF]

, 1949
A. E. Mourant
openalex   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

Nature Communications, 2018
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data ...
S. Oh, B. Sohn, J. Cheong, Sang-Bae Kim, Jae Eun Lee, K. Park, S. Lee, Jong-Lyul Park, Yun‐Yong Park, Hyun-Sung Lee, Hee-Jin Jang, E. Park, Sang-Cheol Kim, Jeonghoon Heo, I. Chu, You-jin Jang, Y. Mok, Wonkyung Jung, B. Kim, A. Kim, J. Cho, J. Lim, Y. Hayashi, Shumei Song, E. Elimova, Jeannelyn S. Estralla, Jeffrey H. Lee, M. Bhutani, Yiling Lu, Wenbin Liu, Jeeyun Lee, W. Kang, S. Kim, S. Noh, G. Mills, Seon-Young Kim, J. Ajani, Ju-Seog Lee   +37 more
semanticscholar   +1 more source