Results 101 to 110 of about 2,449,755 (371)

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

Genes & Development, 2017
Here, Ritschka et al. provide insight into new functions for the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a paracrine manner. They show that SASP promotes a proregenerative response through
Birgit Ritschka, M. Storer, A. Mas, Florian Heinzmann, M. C. Ortells, J. Morton, O. Sansom, L. Zender, W. M. Keyes   +8 more
semanticscholar   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

SPATIAL ANALYSIS TO SUPPORT GEOGRAPHIC TARGETING OF GENOTYPES TO ENVIRONMENTS

Frontiers in Physiology, 2013
Crop improvement efforts have benefited greatly from advances in available data, computing technology and methods for targeting genotypes to environments. These advances support the analysis of genotype by environment interactions to understand how well
Glenn eHyman, Dave eHodson, Peter eJones
doaj   +1 more source

Phenotype affinity mediated interactions can facilitate the evolution of cooperation [PDF]

arXiv, 2018
We study the coevolutionary dynamics of the diversity of phenotype expression and the evolution of cooperation in the Prisoner's Dilemma game. Rather than pre-assigning zero-or-one interaction rate, we diversify the rate of interaction by associating it with the phenotypes shared in common.
arxiv  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Asthma phenotypes

Journal of General and Family Medicine, 2017
AbstractCurrently, categorization based on cluster analysis by objectively grasping the diversity of pathology is being conducted and the diversity of asthma is being categorized as phenotypes. Clinically, there is categorization based on aging and on allergic diathesis which is clinically useful; however, it has not, up to now, come to the point of ...
Hirose, Masahiro, Horiguchi, Takahiko
openaire   +2 more sources

Phenotype

Definitions, 2020
B ARBARA McCLINTOCK’s remarkable life spanned the history of genetics in the 20th century. Though technically rooted in MENDEL’S experiments carried out decades earlier, the science of genetics began with the rediscovery of his work at the turn of the ...
V., Fedoroff
semanticscholar   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Phenotype Inference with Semi-Supervised Mixed Membership Models [PDF]

arXiv, 2018
Disease phenotyping algorithms process observational clinical data to identify patients with specific diseases. Supervised phenotyping methods require significant quantities of expert-labeled data, while unsupervised methods may learn non-disease phenotypes. To address these limitations, we propose the Semi-Supervised Mixed Membership Model (SS3M) -- a
arxiv  

Dimensionality-Reduction in the Drosophila Wing as Revealed by Landmark-Free Measure-ments of Phenotype [PDF]

arXiv, 2020
Organismal phenotypes emerge from a complex set of genotypic interactions. While technological advances in sequencing provide a quantitative description of an organism's genotype, characterization of an organism's physical phenotype lags far behind. Here, we relate genotype to the complex and multi-dimensional phenotype of an anatomical structure using
arxiv