Results 11 to 20 of about 3,800,975 (380)

Lamin A/C Mechanosensor Drives Tumor Cell Aggressiveness and Adhesion on Substrates With Tissue-Specific Elasticity

Frontiers in Cell and Developmental Biology, 2021
Besides its structural properties in the nucleoskeleton, Lamin A/C is a mechanosensor protein involved in perceiving the elasticity of the extracellular matrix.
Enrica Urciuoli, Valentina D’Oria, Stefania Petrini, Barbara Peruzzi   +3 more
doaj   +1 more source

The Human Phenotype Ontology in 2024: phenotypes around the world

Nucleic Acids Research, 2023
The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity ...
M. Gargano, N. Matentzoglu, Ben Coleman, Eunice B Addo-Lartey, A. V. Anagnostopoulos, Joel Anderton, P. Avillach, Anita M Bagley, E. Bakštein, J. Balhoff, Gareth Baynam, S. Bello, Michael Berk, Holli Bertram, Somer Bishop, H. Blau, David F Bodenstein, Pablo Botas, K. Boztug, Jolana Čady, Tiffany J. Callahan, Rhiannon Cameron, S. Carbon, Francisco Castellanos, J. Caufield, L. Chan, C. Chute, J. Cruz-Rojo, N. Dahan-Oliel, Jon R. Davids, Maud de Dieuleveult, Vinícius De Souza, B. D. de Vries, Esther de Vries, J. R. DePaulo, Beata Derfalvi, F. Dhombres, Claudia Diaz-Byrd, A. Dingemans, Bruno Donadille, Michael H Duyzend, R. Elfeky, Shahim Essaid, Carolina Fabrizzi, G. Fico, Helen V Firth, Y. Freudenberg-Hua, J. Fullerton, D. Gabriel, Kimberly Gilmour, J. Giordano, F. Goes, R. G. Moses, Ian Green, Matthias Griese, T. Groza, Weihong Gu, Julia Guthrie, Benjamin M. Gyori, A. Hamosh, M. Hanauer, Kateřina Hanušová, Y. He, Harshad B. Hegde, I. Helbig, Kateřina Holasová, C. Hoyt, Shangzhi Huang, Eric Hurwitz, Julius O. B. Jacobsen, Xiaofeng Jiang, Lisa Joseph, Kamyar Keramatian, Bryan King, Katrin Knoflach, D. Koolen, Megan L Kraus, Carlo Kroll, M. Kusters, Markus S. Ladewig, D. Lagorce, Meng-Chuan Lai, P. Lapunzina, Bryan Laraway, D. Lewis-Smith, Xiarong Li, C. Lucano, Marzieh Majd, M. Marazita, V. Martínez-Glez, Toby H. McHenry, Melvin G. McInnis, J. McMurry, Michaela Mihulová, Caitlin E. Millett, Philip B Mitchell, V. Moslerová, Kenji Narutomi, S. Nematollahi, J. Nevado, A. Nierenberg, N. N. Čajbiková, J. Nurnberger, S. Ogishima, Daniel Olson, A. Ortiz, H. Pachajoa, G. Perez de Nanclares, Amy Peters, Tim E. Putman, Christina K. Rapp, A. Rath, J. Reese, Lauren Rekerle, Angharad M. Roberts, Suzy Roy, Stephan J. Sanders, C. Schuetz, E. Schulte, Thomas G. Schulze, M. Schwarz, K. Scott, D. Seelow, B. Seitz, Yiping Shen, M. Similuk, Eric S Simon, Balwinder Singh, D. Smedley, Cynthia L. Smith, Jake T Smolinsky, Sarah H. Sperry, Elizabeth Stafford, Ray Stefancsik, Robin Steinhaus, R. Strawbridge, J. C. Sundaramurthi, P. Talapova, J. T. Tenorio Castaño, P. Tesner, R. Thomas, A. Thurm, M. Turnovec, M. V. van Gijn, N. Vasilevsky, M. Vlčková, Anita Walden, Kai Wang, R. Wapner, James S. Ware, A. A. Wiafe, Samuel A Wiafe, L. Wiggins, Andrew Williams, Chen Wu, M. J. Wyrwoll, Hui Xiong, Nefize Yalin, Yasunori Yamamoto, L. Yatham, Anastasia K. Yocum, A. H. Young, Z. Yüksel, Peter P Zandi, A. Zankl, I. Zarante, M. Zvolský, Sabrina Toro, Leigh Carmody, N. Harris, M. Munoz-Torres, D. Danis, Christopher J. Mungall, Sebastian Köhler, Melissa A. Haendel, Peter N. Robinson   +175 more
semanticscholar   +1 more source

Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour

Scientific Reports, 2022
Protocadherin 9 (Pcdh9) is a member of the cadherin superfamily and is uniquely expressed in the vestibular and limbic systems; however, its physiological role remains unclear.
Masato Uemura, Tamio Furuse, Ikuko Yamada, Tomoko Kushida, Takaya Abe, Keiko Imai, Soichi Nagao, Moeko Kudoh, Katsuhiko Yoshizawa, Masaru Tamura, Hiroshi Kiyonari, Shigeharu Wakana, Shinji Hirano   +12 more
doaj   +1 more source

Spike protein is a key target for stronger and more persistent T-cell responses—a study of mild and asymptomatic SARS-CoV-2 infection

International Journal of Infectious Diseases, 2023
Objectives: Understanding the immune response in very mild and asymptomatic COVID-19 is crucial for developing effective vaccines and immunotherapies, yet remains poorly characterized.
Ivan Ssali, Susan Mugaba, Arthur Kalyebi Watelo, Juliana Bemanzi, Joseph Ssebwana Katende, Gerald Kevin Oluka, Violet Ankunda, Claire Baine, Laban Kato, Nathan Onyachi, Moses Muwanga, Mark Jjuuko, John Kayiwa, Christopher Nsereko, Betty Oliver Auma, Daniela Weiskopf, Alessandro Sette, Tom Lutalo, Monica Musenero, Pontiano Kaleebu, Jennifer Serwanga   +20 more
doaj   +1 more source

Phenotyping Cardiogenic Shock [PDF]

Journal of the American Heart Association, 2021
Background Cardiogenic shock (CS) is a heterogeneous syndrome with varied presentations and outcomes. We used a machine learning approach to test the hypothesis that patients with CS have distinct phenotypes at presentation, which are associated with unique clinical profiles and in‐hospital mortality.
Elric Zweck, Katherine L. Thayer, Ole K. L. Helgestad, Manreet Kanwar, Mohyee Ayouty, A. Reshad Garan, Jaime Hernandez‐Montfort, Claudius Mahr, Detlef Wencker, Shashank S. Sinha, Esther Vorovich, Jacob Abraham, William O’Neill, Song Li, Gavin W. Hickey, Jakob Josiassen, Christian Hassager, Lisette O. Jensen, Lene Holmvang, Henrik Schmidt, Hanne B. Ravn, Jacob E. Møller, Daniel Burkhoff, Navin K. Kapur   +23 more
openaire   +6 more sources

Rapid, early, and potent Spike-directed IgG, IgM, and IgA distinguish asymptomatic from mildly symptomatic COVID-19 in Uganda, with IgG persisting for 28 months

Frontiers in Immunology, 2023
IntroductionUnderstanding how spike (S)-, nucleoprotein (N)-, and RBD-directed antibody responses evolved in mild and asymptomatic COVID-19 in Africa and their interactions with SARS-CoV-2 might inform development of targeted treatments and vaccines ...
Jennifer Serwanga, Jennifer Serwanga, Violet Ankunda, Jackson Sembera, Laban Kato, Gerald Kevin Oluka, Gerald Kevin Oluka, Claire Baine, Geoffrey Odoch, John Kayiwa, Betty Oliver Auma, Mark Jjuuko, Christopher Nsereko, Matthew Cotten, Matthew Cotten, Nathan Onyachi, Moses Muwanga, Tom Lutalo, Julie Fox, Monica Musenero, Pontiano Kaleebu, Pontiano Kaleebu, The COVID-19 Immunoprofiling Team, The COVID-19 Immunoprofiling Team, Patricia Namubiru, Hermilia Christine Akoli, Susan Mugaba, Amina Nalumansi, Geoffrey Odoch, Kibengo Freddie, Deus Mwesigwa, Joseph Ssebwana Katende   +31 more
doaj   +1 more source

How vascular smooth muscle cell phenotype switching contributes to vascular disease

Cell Communication and Signaling, 2022
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated type, also known as synthetic VSMCs, with a ...
Genmao Cao, Xuezhe Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin, Honglin Dong   +5 more
semanticscholar   +1 more source

Asthma phenotypes [PDF]

Current Allergy and Asthma Reports, 2009
The many roads leading to the syndrome of asthma have proven to be intricately interconnected. The chronic inflammation of asthma is characterized by airway hyperreactivity and variable reversibility. Past classification systems relied on assessment of daily impairment and the distinction between intrinsic (nonallergic) and extrinsic (allergic).
Handoyo, Steve, Rosenwasser, Lanny J.
openaire   +2 more sources

A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness

Sensors, 2022
The measurement of biological tissues’ dielectric properties plays a crucial role in determining the state of health, and recent studies have reported microwave biosensing to be an innovative method with great potential in this field.
Livio D’Alvia, Serena Carraro, Barbara Peruzzi, Enrica Urciuoli, Luigi Palla, Zaccaria Del Prete, Emanuele Rizzuto   +6 more
doaj   +1 more source

Phenotype of Chronic Obstructive Pulmonary Disease Based on Computed Tomography–Defined Underlying Pathology [PDF]

Tuberculosis and Respiratory Diseases, 2022
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease. Not all patients with COPD respond to available drugs. Identifying respondents to therapy is critical to delivering the most appropriate treatment and avoiding ...
Won-Dong Kim
doaj   +1 more source