Results 41 to 50 of about 2,545,958 (345)

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

open access: yesCells, 2020
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells.
J. Park, Woo Yang Pyun, H. Park
semanticscholar   +1 more source

Detection of the Strains Induced in Murine Tibias by Ex Vivo Uniaxial Loading with Different Sensors

open access: yesSensors, 2019
In this paper, the characterization of the main techniques and transducers employed to measure local and global strains induced by uniaxial loading of murine tibiae is presented.
Emanuele Rizzuto   +7 more
doaj   +1 more source

Clinical and genetic study of 12 Chinese Han families with nonsyndromic deafness

open access: yesMolecular Genetics & Genomic Medicine, 2020
Background Nonsyndromic hearing loss is clinically and genetically heterogeneous. In this study, we characterized the clinical features of 12 Chinese Han deaf families in which mutations in common deafness genes GJB2, SLC26A4, and MT‐RNR1 were excluded ...
Di Wu   +10 more
doaj   +1 more source

Population genetic structure of two herds of Aberdeen Angus cattle breed in Colombia

open access: yesRevista Colombiana de Ciencias Pecuarias, 2020
Background: Two biotypes of Aberdeen Angus cattle breed, known as Old Type and New Type, that differ in their origin and beef production are formally recognized. In Colombia, this breed has been commercialized for approximately 80 years.
Alejandra M. Moreno-Sierra   +2 more
doaj   +1 more source

Genetic Workup for Charcot–Marie–Tooth Neuropathy: A Retrospective Single-Site Experience Covering 15 Years

open access: yesLife, 2022
Charcot–Marie–Tooth (CMT) disease is the most commonly inherited neurological disorder. This study includes patients affected by CMT during regular follow-ups at the CMT clinic in Genova, a neuromuscular university center in the northwest of Italy, with ...
Chiara Gemelli   +22 more
doaj   +1 more source

OMIM.org: leveraging knowledge across phenotype–gene relationships

open access: yesNucleic Acids Res., 2018
For over 50 years Mendelian Inheritance in Man has chronicled the collective knowledge of the field of medical genetics. It initially cataloged the known X-linked, autosomal recessive and autosomal dominant inherited disorders, but grew to be the primary
J. Amberger   +3 more
semanticscholar   +1 more source

Vicia faba - Past, Present and Future Breeding Perspectives in Romania

open access: yesBulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture, 2022
Vicia faba is one of the oldest vegetables in the world, recognized as a valuable protein-rich food and with high adaptability to grow in all climatic conditions, but despite this, in Romania is an underutilized crop, with few studies conducted so far ...
Elena BARCANU   +4 more
doaj   +1 more source

PhenoScanner: a database of human genotype–phenotype associations

open access: yesBioinform., 2016
Summary: PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate ‘phenome scans’, the cross-referencing of genetic variants with many phenotypes, to help aid ...
James R. Staley   +11 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

Visualization of Small Vessels by Micro–Computed Tomography Using Titanium Dioxide Nanoparticles as a Novel Contrast Agent

open access: yesInternational Journal of Biomedical Imaging
Angiography by means of micro–computed tomography (m-CT) is extensively used for the diagnosis of vasculature disorders. To establish a connection between m-CT images and genuine histopathology findings, we developed two novel titanium dioxide ...
Taku Goto   +4 more
doaj   +1 more source

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