Analysis of Genotype-Phenotype Association using Genomic Informational Field Theory (GIFT) [PDF]
arXiv, 2022 We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we show how the ordering of phenotype data can lead to quantification of the effect of genotype.
arxiv
International Journal of Infectious Diseases, 2023 Objectives: Understanding the immune response in very mild and asymptomatic COVID-19 is crucial for developing effective vaccines and immunotherapies, yet remains poorly characterized.
Ivan Ssali +20 more
doaj
Modeling neurodegeneration in Caenorhabditis elegans
Disease Models & Mechanisms, 2020 The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors.
Kim A. Caldwell +2 more
doaj +1 more source
Clinical Case Reports, 2021 The rare cisAB subgroups inherited from a single parent are characterized by the activities of dual A and B glycosyltransferases encoded by a gene on one chromosome.
Yanan Zhang, Nuochuan Wang, Yongji Tian
doaj +1 more source
Identification of side population cells in mouse primordial germ cells and prenatal testis [PDF]
, 2011 In mammals, the stem cells of spermatogenesis are derived from an embryonic cell population called primordial germ cells (PGCs). Spermatogonial stem cells displaying the "side population" (SP) phenotype have been identified in the immature and adult ...
De Felici, Massimo +6 more
core +2 more sources
Implementation of Zebrafish Ontologies for Toxicology Screening
Frontiers in Toxicology, 2022 Toxicological evaluation of chemicals using early-life stage zebrafish (Danio rerio) involves the observation and recording of altered phenotypes. Substantial variability has been observed among researchers in phenotypes reported from similar studies, as
Anne E. Thessen +26 more
doaj +1 more source
Computable Phenotypes for Post-acute sequelae of SARS-CoV-2: A National COVID Cohort Collaborative Analysis [PDF]
arXiv, 2023 Post-acute sequelae of SARS-CoV-2 (PASC) is an increasingly recognized yet incompletely understood public health concern. Several studies have examined various ways to phenotype PASC to better characterize this heterogeneous condition. However, many gaps in PASC phenotyping research exist, including a lack of the following: 1) standardized definitions ...
arxiv
Phenotype and TCR-gamma gene rearrangements in a Malaysian cohort of T-cell leukaemia/lymphoma cases [PDF]
, 2010 T cells undergo a series of complex phenotypic changes before achieving maturation. Discrete stages of T-cell differentiation are simplified to four stages (pro-, pre-, cortical and mature-T cell) and used in the classification of T-cell leukaemia.
Abdullah, Maha +2 more
core +1 more source
Treating Macrophages with Anti-inflammatory Nanoparticles as a Strategy to Improve Muscle Repair [PDF]
, 2019 The macrophage is an immune cell that is involved in host defense. More recent research, however, has revealed that they also play a central role in mediating the skeletal muscle regenerative process.
Yan, Derek
core +1 more source
A phenotype of resiliency? cross-sectional psychobiological differences between caregivers who are vulnerable vs. resilient to depression, and controls [PDF]
, 2016 Introduction: Being a caregiver of chronically ill children is a source of chronic-psychological stress affecting general physical and mental health.
Bersani, F. S. +2 more
core