Results 51 to 60 of about 2,545,958 (345)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

Clinical and Developmental Immunology, 2010
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
Behnam Sadeghi, Suleiman Al-Hashmi, Zuzana Hassan, Bjorn Rozell, Hernan Concha, Carin Lundmark, Kjell-Olov Grönvik, Manuchehr Abedi-Valugerdi, Moustapha Hassan   +8 more
doaj   +1 more source

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group

Clinical and Translational Science, 2019
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and ...
K. Caudle, K. Sangkuhl, Michelle Whirl‐Carrillo, J. Swen, Cyrine E. Haidar, T. Klein, Roseann S. Gammal, M. Relling, S. Scott, D. Hertz, H. Guchelaar, A. Gaedigk   +11 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Systemic genome-epigenome analysis captures a lineage-specific super-enhancer for MYB in gastrointestinal adenocarcinoma

Molecular Systems Biology
Gastrointestinal adenocarcinoma is a major cancer type for the digestive system, ranking as the top cause of cancer-related deaths worldwide. While there has been extensive research on mutations in protein-coding regions, the knowledge of the landscape ...
Fuyuan Li, Shangzi Wang, Lian Chen, Ning Jiang, Xingdong Chen, Jin Li   +5 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Neuronal ceroid lipofuscinosis in the South American-Caribbean region: An epidemiological overview

Frontiers in Neurology, 2022
Neuronal ceroid lipofuscinoses (NCLs) comprise 13 hereditary neurodegenerative pathologies of very low frequency that affect individuals of all ages around the world. All NCLs share a set of symptoms that are similar to other diseases.
Guillermo Guelbert, Guillermo Guelbert, Ana Clara Venier, Ana Clara Venier, Ana Clara Venier, Ines Adriana Cismondi, Ines Adriana Cismondi, Adriana Becerra, Adriana Becerra, Juan Carlos Vazquez, Elmer Andrés Fernández, Ana Lucía De Paul, Ana Lucía De Paul, Norberto Guelbert, Norberto Guelbert, Ines Noher, Ines Noher, Favio Pesaola, Favio Pesaola   +18 more
doaj   +1 more source

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

Nucleic Acids Res., 2018
The Human Phenotype Ontology (HPO)—a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases—is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world.
Sebastian Köhler, Leigh Carmody, N. Vasilevsky, Julius O. B. Jacobsen, D. Danis, J. Gourdine, M. Gargano, N. Harris, Nicolas Matentzoglu, J. McMurry, David Osumi-Sutherland, Valentina Cipriani, J. Balhoff, Tom Conlin, H. Blau, Gareth Baynam, Richard Palmer, Dylan Gratian, H. Dawkins, Michael Segal, A. Jansen, A. Muaz, Willie H. Chang, J. Bergerson, S. Laulederkind, Z. Yüksel, S. Beltran, A. Freeman, P. Sergouniotis, D. Durkin, A. L. Storm, M. Hanauer, M. Brudno, S. Bello, M. Sincan, Kayli Rageth, M. Wheeler, R. Oegema, Halima Lourghi, Maria G. Della Rocca, R. Thompson, Francisco Castellanos, J. Priest, C. Cunningham-Rundles, Ayushi Hegde, R. Lovering, C. Hajek, A. Olry, L. Notarangelo, M. Similuk, X. A. Zhang, D. Gómez-Andrés, Hanns Lochmüller, H. Dollfus, S. Rosenzweig, S. Marwaha, A. Rath, K. Sullivan, Cynthia L. Smith, J. Milner, D. Leroux, C. Boerkoel, A. Klion, M. Carter, T. Groza, D. Smedley, M. Haendel, C. Mungall, Peter N. Robinson   +68 more
semanticscholar   +1 more source

The Universal Phenotype

, 2019
Organisms. Journal of Biological Sciences, V. 3, N. 2 (2019)
Alessio Martino, Alessandro Giuliani, Antonello Rizzi   +2 more
openaire   +2 more sources

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source