Results 51 to 60 of about 2,909,871 (334)

Perspective: Is Random Monoallelic Expression a Contributor to Phenotypic Variability of Autosomal Dominant Disorders?

Frontiers in Genetics, 2017
Several factors have been proposed as contributors to interfamilial and intrafamilial phenotypic variability in autosomal dominant disorders, including allelic variation, modifier genes, environmental factors and complex genetic and environmental ...
Baoheng Gui, Baoheng Gui, Jesse Slone, Taosheng Huang   +3 more
doaj   +1 more source

Arrhythmogenic Ventricular Cardiomyopathy

JACC: Case Reports, 2021
After a 20-year-old woman suddenly died, autopsy showed characteristic findings of biventricular arrhythmogenic cardiomyopathy. Screening of her family members revealed the same desmoplakin gene mutation and imaging abnormalities predominantly involving ...
Aranyak S. Rawal, MD, Tara VanCleave, BS, Neeraja Yedlapati, MD, Jeffery E. Saffitz, MD, PhD, William James Craigen, MD, PhD, John L. Jefferies, MD, MPH   +5 more
doaj   +1 more source

Compositions comprising citrate and applications thereof [PDF]

, 2016
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a ...
Yang, Jian
core   +1 more source

Phenotype and Function of Activated Natural Killer Cells From Patients With Prostate Cancer: Patient-Dependent Responses to Priming and IL-2 Activation

Frontiers in Immunology, 2019
Background: Although immunotherapy has emerged as the “next generation” of cancer treatments, it has not yet been shown to be successful in the treatment of patients with prostate cancer, for whom therapeutic options remain limited to radiotherapy and ...
Simon P. Hood, Gemma A. Foulds, Heather Imrie, Stephen Reeder, Stéphanie E. B. McArdle, Masood Khan, Alan Graham Pockley   +6 more
doaj   +1 more source

A phenotype of resiliency? cross-sectional psychobiological differences between caregivers who are vulnerable vs. resilient to depression, and controls [PDF]

, 2016
Introduction: Being a caregiver of chronically ill children is a source of chronic-psychological stress affecting general physical and mental health.
Bersani, F. S., Epel, E. S., Wolkowitz, O. M.   +2 more
core  

Effect of Media and Estrogen on Morphological Change in Candida albicans [PDF]

, 2020
Introduction: Candida albicans (C. albicans), an opportunistic pathogen, lives symbiotically within the intestine of its human host. Temperature and chemical factors have been shown to induce a morphological change in C.
Bouyer, Patrice G., Camp, Paige M., Watters, Michael K., Zachara, Idalia Z.   +3 more
core   +1 more source

Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij, Catia Olianti, Herve Brisse, Pier Luigi Di Paolo, Maria Garganese, Tejas Kapadia, Jurgen Schaefer, Hugh Wallace, Simon Wan, Bart de Keizer, Irmina Sefic Pasic, Julian Rogasch   +11 more
wiley   +1 more source

Visualization of Small Vessels by Micro–Computed Tomography Using Titanium Dioxide Nanoparticles as a Novel Contrast Agent

International Journal of Biomedical Imaging
Angiography by means of micro–computed tomography (m-CT) is extensively used for the diagnosis of vasculature disorders. To establish a connection between m-CT images and genuine histopathology findings, we developed two novel titanium dioxide ...
Taku Goto, Ruriko Tanabe, Hirotoshi Shibuya, Masaru Tamura, Shintaro Nomura   +4 more
doaj   +1 more source

Clinical PET Imaging of Microglial Activation: Implications for Microglial Therapeutics in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2018
In addition to extracellular β-amyloid plaques and intracellular neurofibrillary tangles, neuroinflammation has been identified as a key pathological characteristic of Alzheimer’s disease (AD).
Zhiwei Shen, Xinjie Bao, Renzhi Wang
doaj   +1 more source

CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

Frontiers in Pharmacology, 2021
Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view.
Kuntheavy Ing Lorenzini, Jules Desmeules, Victoria Rollason, Stéphane Bertin, Marie Besson, Youssef Daali, Caroline F. Samer   +6 more
doaj   +1 more source