Results 51 to 60 of about 2,449,755 (371)

Fitness of two phenotypes of Harmonia axyridis (Coleoptera: Coccinellidae)

European Journal of Entomology, 2001
The coccinellid H. axyridis shows considerable intraspecific variability of elytral patterns. In this paper, we suggest that a genotype that confers a specific pattern of elytra could also confer other specific autecological attributes.
Antonio O. SOARES, Daniel CODERRE, Henrique SCHANDERL   +2 more
doaj   +1 more source

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

Nucleic Acids Res., 2018
The Human Phenotype Ontology (HPO)—a standardized vocabulary of phenotypic abnormalities associated with 7000+ diseases—is used by thousands of researchers, clinicians, informaticians and electronic health record systems around the world.
Sebastian Köhler, Leigh Carmody, N. Vasilevsky, Julius O. B. Jacobsen, D. Danis, J. Gourdine, M. Gargano, N. Harris, Nicolas Matentzoglu, J. McMurry, David Osumi-Sutherland, Valentina Cipriani, J. Balhoff, Tom Conlin, H. Blau, G. Baynam, Richard Palmer, Dylan Gratian, H. Dawkins, Michael Segal, A. Jansen, A. Muaz, Willie H. Chang, J. Bergerson, S. Laulederkind, Z. Yüksel, S. Beltran, A. Freeman, P. Sergouniotis, D. Durkin, A. L. Storm, M. Hanauer, M. Brudno, S. Bello, M. Sincan, Kayli Rageth, M. Wheeler, R. Oegema, Halima Lourghi, Maria G. Della Rocca, R. Thompson, Francisco Castellanos, J. Priest, C. Cunningham-Rundles, Ayushi Hegde, R. Lovering, C. Hajek, A. Olry, L. Notarangelo, M. Similuk, X. A. Zhang, D. Gómez-Andrés, Hanns Lochmüller, H. Dollfus, S. Rosenzweig, S. Marwaha, A. Rath, K. Sullivan, Cynthia L. Smith, J. Milner, D. Leroux, C. Boerkoel, A. Klion, M. Carter, T. Groza, D. Smedley, M. Haendel, C. Mungall, Peter N. Robinson   +68 more
semanticscholar   +1 more source

Abortigenic but Not Neurotropic Equine Herpes Virus 1 Modulates the Interferon Antiviral Defense

Frontiers in Cellular and Infection Microbiology, 2018
Equine herpesvirus 1 (EHV1) is considered as a major pathogen of Equidae, causing symptoms from mild respiratory disease to late-term abortion and neurological disorders.
Katrien C. K. Poelaert, Jolien Van Cleemput, Kathlyn Laval, Herman W. Favoreel, Gisela Soboll Hussey, Roger K. Maes, Hans J. Nauwynck   +6 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Visualization of Small Vessels by Micro–Computed Tomography Using Titanium Dioxide Nanoparticles as a Novel Contrast Agent

International Journal of Biomedical Imaging
Angiography by means of micro–computed tomography (m-CT) is extensively used for the diagnosis of vasculature disorders. To establish a connection between m-CT images and genuine histopathology findings, we developed two novel titanium dioxide ...
Taku Goto, Ruriko Tanabe, Hirotoshi Shibuya, Masaru Tamura, Shintaro Nomura   +4 more
doaj   +1 more source

Evolution of molecular phenotypes under stabilizing selection [PDF]

J. Stat. Mech. (2013) P01012, 2013
Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution builds on genome evolution in a complicated way, which involves selection, genetic drift, mutations and recombination.
arxiv   +1 more source

CpG island methylator phenotype in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America, 1999
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG island methylation in colorectal cancer, we have used a recently developed ...
M. Toyota, N. Ahuja, Mutsumi Ohe-Toyota, J. Herman, S. Baylin, J. Issa   +5 more
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

Clinical and Developmental Immunology, 2010
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
Behnam Sadeghi, Suleiman Al-Hashmi, Zuzana Hassan, Bjorn Rozell, Hernan Concha, Carin Lundmark, Kjell-Olov Grönvik, Manuchehr Abedi-Valugerdi, Moustapha Hassan   +8 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source