Results 81 to 90 of about 3,800,975 (380)

Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning

open access: yesClinical and Developmental Immunology, 2010
In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT).
Behnam Sadeghi   +8 more
doaj   +1 more source

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms

open access: yesFrontiers in Immunology, 2021
Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic
Chunye Zhang   +4 more
doaj   +1 more source

A phenotype of resiliency? cross-sectional psychobiological differences between caregivers who are vulnerable vs. resilient to depression, and controls [PDF]

open access: yes, 2016
Introduction: Being a caregiver of chronically ill children is a source of chronic-psychological stress affecting general physical and mental health.
Bersani, F. S.   +2 more
core  

Further genetic heterogeneity for autosomal dominant human sutural cataracts [PDF]

open access: yes, 2003
A unique sutural cataract was observed in a 4-generation German family to be transmitted as an isolated autosomal, dominant trait. Since mutations in the gamma-crystallin encoding CRYG genes have previously been demonstrated to be the most frequent ...
Billingsley, G.   +6 more
core   +1 more source

Asthma phenotypes

open access: yesJournal of General and Family Medicine, 2017
AbstractCurrently, categorization based on cluster analysis by objectively grasping the diversity of pathology is being conducted and the diversity of asthma is being categorized as phenotypes. Clinically, there is categorization based on aging and on allergic diathesis which is clinically useful; however, it has not, up to now, come to the point of ...
Hirose, Masahiro, Horiguchi, Takahiko
openaire   +2 more sources

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

LEFT VENTRICULAR REMODELING IN HEART FAILURE (PART ІI): PHENOTYPIC HETEROGENEITY AS A RATIONALE FOR PERSONALIZED PATIENTS` MANAGEMENT

open access: yesКлінічна та профілактична медицина, 2023
Aim: to provide a literature review of the current conсepts on phenotypic heterogeneity of left ventricular (LV) remodeling in heart failure (HF), and highlight the significance of such a diversity for an implementation of personalized patients ...
T.Ya. Chursina   +2 more
doaj   +1 more source

Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]

open access: yes, 2012
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core   +3 more sources

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group

open access: yesClinical and Translational Science, 2019
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and ...
K. Caudle   +11 more
semanticscholar   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

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