Results 81 to 90 of about 2,545,958 (345)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CCNI2 promotes pancreatic cancer through PI3K/AKT signaling pathway

Biomolecules & Biomedicine
Globally, pancreatic cancer is recognized as one of the deadliest malignancies that lacks effective targeted therapies. This study aims to explore the role of cyclin I-like protein (CCNI2), a homolog of cyclin I (CCNI), in the progression of pancreatic ...
Bingyang Hu, Wenzhi Zhang, Changsheng Zhang, Chonghui Li, Ning Zhang, Ke Pan, Xinlan Ge, Tao Wan   +7 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

Genes & Development, 2017
Here, Ritschka et al. provide insight into new functions for the senescence-associated secretory phenotype (SASP), which can reinforce the arrest and induce senescence in a paracrine manner. They show that SASP promotes a proregenerative response through
Birgit Ritschka, M. Storer, A. Mas, Florian Heinzmann, M. C. Ortells, J. Morton, O. Sansom, L. Zender, W. M. Keyes   +8 more
semanticscholar   +1 more source

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

International Journal of Molecular Sciences, 2020
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxidative
Priscila Calle, G. Hotter
semanticscholar   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

The cAMP Receptor Protein (CRP) of Vibrio mimicus Regulates Its Bacterial Growth, Type II Secretion System, Flagellum Formation, Adhesion Genes, and Virulence

Animals
Vibrio mimicus is a serious pathogen in aquatic animals, resulting in significant economic losses. The cAMP receptor protein (CRP) often acts as a central regulator in highly pathogenic pathogens. V.
Ziqi Tian, Fei Xiang, Kun Peng, Zhenyang Qin, Yang Feng, Bowen Huang, Ping Ouyang, Xiaoli Huang, Defang Chen, Weimin Lai, Yi Geng   +10 more
doaj   +1 more source

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

Nature Communications, 2018
Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the immunosuppressive tumor microenvironment and improve innate and adaptive antitumor immunity.
Degao Chen, Jing Xie, R. Fiskesund, Wenqian Dong, Xiaoyu Liang, Jiadi Lv, Xun Jin, Jinyan Liu, Siqi Mo, Tianzhen Zhang, Feiran Cheng, Yabo Zhou, Huafeng Zhang, K. Tang, Jingwei Ma, Yuying Liu, Bo Huang   +16 more
semanticscholar   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Could sex-specific subtypes of hand osteoarthritis exist? A retrospective study in women presenting to secondary care

Frontiers in Pain Research
IntroductionHand osteoarthritis is more common in women, and its risk increases around the time of the menopause. We set out to describe the timing between menopause and the onset of symptomatic hand osteoarthritis (OA), and associations with the use of ...
Malvika Gulati, Malvika Gulati, Gretchen Brewer, Andrew Judge, Andrew Judge, Andrew Judge, Donna Kennedy, Tonia L. Vincent, Tonia L. Vincent, Fiona E. Watt, Fiona E. Watt, Fiona E. Watt   +11 more
doaj   +1 more source