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Ageing-associated phenotypes in mice
Mechanisms of Ageing and Development, 2023Ageing is a continuous process in life featuring progressive damage accumulation that leads to physiological decline, functional deterioration and ultimately death of an organism. Based on the relatively close anatomical and physiological similarity to humans, the mouse has been proven as a valuable model organism in ageing research over the last ...
Kan Xie, Dan Ehninger
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An aging phenotype in the wild
Science, 2019Deterioration of the immune system with age increases winter mortality in Soay ...
Gaillard, Jean-Michel +1 more
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The external phenotype of aging
European Journal of Medical Genetics, 2020Aging is widely studied as a physiological process. Segmental aging can also occur prematurely in Mendelian disorders, and these can act this way as excellent sources of information, specifically for the underlying mechanisms. Adequate recognition of such aging characteristics in Mendelian disorders needs a well-defined phenotype of aging.
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Personality and aging-related immune phenotype
Psychoneuroendocrinology, 2023An aging-related immune phenotype (ARIP) has been defined as a decrease in naïve T cells (TN) relative to the accumulation of memory T cells (TM). Recent research implicates ARIP measures, such as CD4 +TN/TM and CD8 +TN/TM ratios, in multimorbidity and mortality. This study examined whether psychological dispositions that assess how people think, feel,
Yannick, Stephan +4 more
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Clinical Phenotype of Scabies by Age
Pediatrics, 2014OBJECTIVE: Scabies has a clinical presentation that seems to vary according to age. We conducted a prospective study with the goal of delineating the clinical presentation of the disease into 3 groups of age: infants, <2 years; children, 2 to 15 years; and adults, >15 years.
Franck, Boralevi +11 more
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Age is associated with asthma phenotypes
Respirology, 2017ABSTRACTBackground and objectiveThe relationship between age and asthma phenotypes is important as population is ageing, asthma is becoming common in older ages and recently developed treatments for asthma are guided by phenotypes. The aim of this study is to evaluate whether age is associated with specific asthma phenotypes.MethodsThis is a cross ...
Ponte, Eduardo V. +7 more
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2021
It is well established that animal models of α-Klotho deficiency are characterized by an aging phenotype. With the advent of research in the biological mechanisms of aging it has become clear that the kidney-derived α-Klotho protein has a key role in these mechanisms, generally retarding the aging process.
Vervloet, Marc G., Hillebrands, Jan-Luuk
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It is well established that animal models of α-Klotho deficiency are characterized by an aging phenotype. With the advent of research in the biological mechanisms of aging it has become clear that the kidney-derived α-Klotho protein has a key role in these mechanisms, generally retarding the aging process.
Vervloet, Marc G., Hillebrands, Jan-Luuk
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Acetylator phenotypes: Effect of age
European Journal of Clinical Pharmacology, 1984The distribution of acetylator phenotypes in a Hungarian population of 253 Caucasian was studied. The patients were divided into two age groups - the elderly over 60 years, and young below that age. The individuals below the age of 60 years contained an equal proportion of the two acetylator phenotypes.
B, Gachályi +3 more
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Kidney Aging: From Phenotype to Genetics
Rejuvenation Research, 2005Aging is a physiological process that causes structural and functional changes in human body systems, sometimes leading to various organ failure. As far as the kidney is concerned, both genetic factors and environmental agents may influence the tissues damage in elderly people and the related loss of function.
BUEMI, Michele +5 more
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Changing course in ageing research: The Healthy Ageing Phenotype
Maturitas, 2009Ageing is often associated with the aged and the diseased, nevertheless ageing is a process that starts in-uterus and is characterised by a progressive functional loss but not necessarily by the presence of disease and poor quality of life. How to meander through life without crossing the confines of major chronic disease and cognitive and physical ...
Oscar H, Franco +5 more
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