Results 271 to 280 of about 5,719,995 (296)
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Changes in the PCOS phenotype with age
Steroids, 2013Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of reproductive-age women. The diagnosis of PCOS is mainly based on the following three components: (1) hyperandrogenism, (2) oligo-amenorrhea, and (3) the observation of polycystic ovaries on a sonogram. The comorbidities may include insulin resistance, type II diabetes mellitus,
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The aging bladder phenotype is not the direct consequence of bladder aging
Neurourology and Urodynamics, 2019AbstractAimsThe prevalence of urinary dysfunction increases with age, yet therapies are often suboptimal. Incomplete understanding of the linkages between system, organ, and tissue domains across lifespan remains a knowledge gap. If tissue‐level changes drive the aging bladder phenotype, parallel changes should be observed across these domains.
Cara C. Hardy +5 more
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Hyaluronic Acid in Progeria and the Aged Phenotype?
Gerontology, 2009Hyaluronic acid (HA) is implicated in functions such as vascu-larity, morphogenesis, repair, and the general integrity of the extracellular matrix. Hence, it is considered possible that HA is involved in the most conspicuous features of the progeroid phenotype.
K J, Sweeney, A S, Weiss
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HLA Phenotypes in Healthy Aged Subjects
Gerontology, 2009One hundred and seventy-one unrelated elderly healthy subjects selected according to the Senieur protocol (57 men and 114 women), aged 75–104 years, and 405 healthy individuals (238 men and 167 women), aged 18-65 years, were typed for HLA-A, HLA-B, and HLA-DR antigens.
C, Papasteriades +5 more
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The Origins of Aging: Evidence that Aging is an Adaptive Phenotype
Current Aging Science, 2016Aging can be defined as the time-related decline in biological functions which ultimately results in organismal death. Beyond the stage of reproductive maturity as fertility declines, cell and tissue functions come under reduced selection pressure since organismal survival is considered no longer an evolutionary priority.
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Successful Aging: From Phenotype to Genotype
Biological Psychiatry, 2007Despite worldwide interest in the increasing human "healthspan," inadequate experimental attention has been dedicated to identifying genetic influences on successful aging beyond those that influence longevity alone. Although it is an under-studied topic, some promising leads have emerged from the existing genetic studies of successful aging.
Stephen J, Glatt +4 more
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There are two sides to the discussion of phenotypes in vascular aging. One is to acknowledge that different biological phenotypes have a clear interaction with vascular aging and are responsible for modulating its progression or for mediating the effect of different risk factors in its progression.
Cunha, Pedro Guimarães +4 more
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Cunha, Pedro Guimarães +4 more
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Aarskog syndrome: The changing phenotype with age
American Journal of Medical Genetics, 1992AbstractWe describe the Leuven experience with 52 males with Aarskog syndrome particularly with respect to clinical variability, changing phenotype with age, and previously unreported signs.At least 30% of affected males were mentally retarded, two thirds of them at the level of slight mental handicap.
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The Effect of Age on the Phenotype and Function of Developing Thymocytes
Journal of Comparative Pathology, 2010The immune system declines with age leading to a progressive deterioration in the ability to respond to infection and vaccination. Age-associated thymic involution is one of the most recognized changes in the ageing immune system and is believed to be a major contributor towards immunosenescence; however, the precise mechanisms involved in age ...
Aw, D., Da Silva, A. B., Palmer, D. B.
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DNA methylation patterns in aging and aging phenotypes
2019Dottorato di Ricerca in Scienze della Vita, Ciclo ...
Guarasci, Francesco +2 more
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