Results 241 to 250 of about 5,699,048 (257)

Accelerated aging phenotypes in the retinal pigment epithelium of Zmpste24-deficient mice

Biochemical and Biophysical Research Communications, 2022
Age-related macular degeneration (AMD) is a chronic and progressive disease characterized by degeneration of the retinal pigment epithelium (RPE) and retina that ultimately leads to loss of vision. The pathological mechanisms of AMD are not fully known.
Jae-Byoung Chae, Chul-Woo Park, Hyeong Min Lee, Leo Sungwong Choi, Chaehee Park, Junghoon Kim, Jaejin Shin, Jooseung Hyeon, Jihan Lee, Hyungwoo Lee, Hyung Soon Park, Chang-Hoon Nam, Hyewon Chung   +12 more
openaire   +3 more sources

Frailty Phenotype: A Clinical Marker of Age Acceleration in the Older HIV-Infected Population

Epigenomics, 2019
To evaluate the association between DNA methylation and frailty in the HIV-infected population and to investigate the usefulness of assessing frailty as a clinical marker to identify age acceleration.Frailty was assessed according to Fried's frailty phenotype.
Matilde, Sánchez-Conde, Javier, Rodriguez-Centeno, Fernando, Dronda, Juan C, López, Zaida, Jiménez, Juan, Berenguer, María J, Pérez-Elías, Santiago, Moreno, Berta, Rodés, Fátima, Brañas   +9 more
openaire   +2 more sources

Determination of the phenotypic age of the residents of Mexico City. Effect of accelerated aging on lung function and structure

Clinical problems, 2020
Introduction: Phenotypic age (PhA) represents the age-related biological dysregulation and the complexity of the aging process better than chronological age, but it is difficult to estimate. Recently, a multi-system-based aging equation was proposed to determine PhA.
Ivette Buendia Roldán, Rosario Fernandez-Plata, Annie Pardo, Moises Selman   +3 more
openaire   +1 more source

Accelerated biological aging in patients with degenerative spine diseases: the impact of modifiable lifestyle factors on phenotypic age

The Spine Journal
Aging is influenced by genetic, environmental, and lifestyle factors, and chronological age alone may fail to capture one's true biological aging. Degenerative spinal disease (DSD) is associated with accelerated health decline, which could manifest as an increased Phenotypic Age (PhenoAge).This study aimed to investigate the association between ...
Mitsuru Yagi, Ryo Mizukoshi, Ryosuke Maruiwa, Norihiro Isogai, Haruki Funao, Retsu Fujita   +5 more
openaire   +2 more sources

Chronic heat stress induces neurodegeneration and accelerates aging phenotypes in mice

Physiology
Repeat exposure to heat is known to contribute to increased risk for cardiovascular and neurodegenerative diseases. This repeat exposure to heat can lead to chronic heat stress (HS), defined as an internal body temperature of 40°C, but less than 41°C.
John Brown, Genesis Mercado-Feliciano, Oscar Spears, Bryan Becker, Caroline Grady   +4 more
openaire   +1 more source

Physio-cognitive decline as the accelerated aging phenotype

Archives of Gerontology and Geriatrics, 2020
Liang-Kung, Chen, Hidenori, Arai
openaire   +2 more sources

Contribution of Phenotypic Age Acceleration and Body Mass Index to Psoriasis Risk in US Adults

Experimental Dermatology
ABSTRACT Psoriasis, a prevalent chronic inflammatory skin disease, substantially impairs patients' quality of life and is frequently linked to numerous systemic comorbidities. We aimed to investigate whether phenotypic age acceleration (PhenoAge‐accel) and obesity synergistically affect the risk of psoriasis. This
Yun‐Ni Lin, Xiang‐Hui Huang, Yuan‐Li Meng, Juan Liang, Wen‐Qi Zhao, Wen‐Hao Liu   +5 more
exaly   +3 more sources

Dietary inflammatory index and depressive symptoms as mediators between social disadvantage and accelerated phenotypic aging

Journal of Affective Disorders
Socially disadvantaged populations are at higher risk for adverse health outcomes. Psychosocial and lifestyle factors may serve as key pathways linking socioeconomic status to biological aging. However, evidence regarding the relationship between social disadvantage and accelerated aging remains limited.
Mengke, Chen, Qingmei, Gao, Xinfang, Zhu, Jun, Zhang, Rong, Xia, Qi, Zhang   +5 more
openaire   +2 more sources

Association of phenotypic age acceleration with all-cause and cardiovascular disease-specific mortality in individuals with prediabetes and diabetes: results from the NHANES study

Journal of Endocrinological Investigation, 2022
exaly  

The association between methylmalonic acid, a biomarker of mitochondria dysfunction, and phenotypic age acceleration: A population-based study

Archives of Gerontology and Geriatrics
Bing Cao, Dan Liu
exaly