Results 51 to 60 of about 156,060 (249)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genetic variability, correlation and path analysis in mango ginger (Curcuma amada ROXB.)

Electronic Journal of Plant Breeding, 2022
The present investigation was carried out at the Research Farm, Department of Genetics and Plant Breeding, Navsari Agricultural University, Navsari, Gujarat during the kharif, 2018. Twelve different quantitative characters related to rhizome yield were
Raval Kalpesh*, R. K. Patel, Rajesh Panchal and K. G. Modha
doaj   +1 more source

Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana. [PDF]

, 2019
Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations.
Cooper, Martha D, Roe, Judith L, Runcie, Daniel E, Schmitt, Johanna, Taylor, Mark A, Welch, Stephen M, Wilczek, Amity M   +6 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The causal meaning of Fisher's average effect [PDF]

, 2013
In order to formulate the Fundamental Theorem of Natural Selection, Fisher defined the average excess and average effect of a gene substitution. Finding these notions to be somewhat opaque, some authors have recommended reformulating Fisher's ideas in ...
Chow, Carson C., Lee, James J.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Characterisation of sweet stem sorghum genotypes for bio-ethanol production

Acta Agriculturae Scandinavica. Section B, Soil and Plant Science, 2018
In an effort to characterise and select promising sweet stem sorghum genotypes with enhanced biofuel productivity, the present study investigated phenotypic variability present among diverse sweet stem sorghum genotypes based on ethanol production and ...
Precious Mangena, Hussein Shimelis, Mark Laing   +2 more
doaj   +1 more source

Variability, heritability and genetic advance for yield and quality components in interspecific F1 hybrids of cotton

Electronic Journal of Plant Breeding, 2017
Assessment of genetic variability using appropriate parameters like phenotypic coefficient of variation (PCV), genotypic coefficient of variation (GCV), heritability (h2), and genetic advance (GA) are really necessary to start an efficient breeding ...
Isong Abasianyanga and, P. Amala Balu
doaj   +1 more source

Genetic studies on variability for quantitative traits in finger millet (Eluesine coracana L. Gaertn)

Electronic Journal of Plant Breeding, 2022
In the present investigation, eighteen finger millet genotypes were raised in randomized block design to study about the genetic variability for quantitative traits.
S. Divya1, K. Geetha1*, R. Siva kumar1, A. Nirmala Kumari2 and M. Rajesh2
doaj   +1 more source