Results 81 to 90 of about 832,396 (367)
The selective advantage of reaction norms for environmental tolerance [PDF]
, 1992 A tolerance curve defines the dependence of a genotype's fitness on the state of an environmental gradient. It can be characterized by a mode (the genotype's optimal environment) and a width (the breadth of adaptation). It seems possible that one or both
Gabriel, Wilfried, Lynch, Michael
core +1 more source
Phenotypic plasticity in response to climate change: the importance of cue variation
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 Phenotypic plasticity is a major mechanism of response to global change. However, current plastic responses will only remain adaptive under future conditions if informative environmental cues are still available. We briefly summarize current knowledge of
Suzanne Bonamour +3 more
semanticscholar +1 more source
Disordered chromatin packing regulates phenotypic plasticity
Science Advances, 2020 The CPMC model demonstrates the regulatory role of chromatin’s physical structure on transcription and phenotypic plasticity. Three-dimensional supranucleosomal chromatin packing plays a profound role in modulating gene expression by regulating ...
R. Virk +11 more
semanticscholar +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Should Root Plasticity Be a Crop Breeding Target?
Frontiers in Plant Science, 2020 Root phenotypic plasticity has been proposed as a target for the development of more productive crops in variable environments. However, the plasticity of root anatomical and architectural responses to environmental cues is highly complex, and the ...
Hannah M. Schneider, Jonathan P. Lynch
doaj +1 more source
Beyond buying time: the role of plasticity in phenotypic adaptation to rapid environmental change
Philosophical Transactions of the Royal Society of London. Biological Sciences, 2019 How populations and species respond to modified environmental conditions is critical to their persistence both now and into the future, particularly given the increasing pace of environmental change.
R. Fox +4 more
semanticscholar +1 more source
Phenotypic Plasticity Contributes to Maize Adaptation and Heterosis
Molecular biology and evolution, 2020 Plant phenotypic plasticity describes altered phenotypic performance of an individual when grown in different environments. Exploring genetic architecture underlying plant plasticity variation may help mitigate the detrimental effects of a rapidly ...
N. Liu +4 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome [PDF]
, 2019 The ecological theory of island biogeography suggests that mainland populations should be more genetically divergent from those on large and distant islands rather than from those on small and close islets.
Aceto, S. +7 more
core +1 more source
Phenotypic plasticity of carbon fixation stimulates cyanobacterial blooms at elevated CO2
Science Advances, 2020 Physiological acclimation to elevated CO2 will intensify cyanobacterial blooms in lakes. Although phenotypic plasticity is a widespread phenomenon, its implications for species responses to climate change are not well understood.
Xing Ji +4 more
semanticscholar +1 more source