Results 81 to 90 of about 215,177 (294)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Reproductive isolation between two populations of Aglaoctenus lagotis , a funnel-web wolf spider [PDF]

, 2015
Aglaoctenus lagotis (Lycosidae: Sosippinae) is a spider that, in contrast to the predominant wandering habit of the family, constructs funnel webs.
Aisenberg, Aisenberg, Alfredo V. Peretti, Ayoub, Barlow, Barluenga, Barth, Barthel, Baruffaldi, Baruffaldi, Begon, Brady, Butlin, Candolin, Capocasale, Chiarle, Claridge, Claridge, Clark, Costa, Costa-Schmidt, Coyne, Coyne, Crews, De Busschere, De Witt, Eberhard, Elias, Fernando G. Costa, Foelix, Futuyma, Gabirot, Gabirot, Ghalambor, Gillespie, González, González, González-Zuarth, Hammer, Hebets, Hebets, Kitano, Kronestedt, Kuppernagel, Leonard, Macarena González, Macías-Ordóñez, Marchiori, Mayr, Michel, Miller, Moraiti, Morrone, Nossil, Oh, Oxford, Piacentini, Pigliucci, Pillay, Pröhl, Puzin, Reiskind, Roberts, Roberts, Rypstra, Saarikettu, Santos, Santos, Singer, Stefani, Stefani, Stefani, Stratton, Taylor, The Marie Curie SPECIATION Network, Tregenza, Töpfer-Hofmann, Uetz, Uetz, Veen, Velásquez, Verrell, Verrell, Verzijden, West-Eberhard, West-Eberhard, Wyman   +86 more
core   +1 more source

Time to exploit phenotypic plasticity [PDF]

Journal of Experimental Botany, 2020
This article comments on:Diouf I, Derivot L, Koussevitzky S, Carretero Y, Bitton F, Moreau L, Causse M. 2020. Genetic basis of phenotypic plasticity and genotype×environment interaction in a multi-parental tomato population. Journal of Experimental Botany 71, 5365–5376.
openaire   +6 more sources

Evolution of generalists by phenotypic plasticity [PDF]

iScience, 2019
AbstractAdapting organisms face a tension between specializing their phenotypes for certain ecological tasks or developing generalist strategies which permit persistence in multiple environmental conditions. Understanding when and how generalists or specialists evolve is therefore an important question in evolutionary dynamics.
Fraebel, David T., Gowda, Karna, Mani, Madhav, Kuehn, Seppe   +3 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Weak gene–gene interaction facilitates the evolution of gene expression plasticity

BMC Biology, 2023
Background Individual organisms may exhibit phenotypic plasticity when they acclimate to different conditions. Such plastic responses may facilitate or constrain the adaptation of their descendant populations to new environments, complicating their ...
Hao-Chih Kuo, Cheng-Te Yao, Ben-Yang Liao, Meng-Pin Weng, Feng Dong, Yu-Cheng Hsu, Chih-Ming Hung   +6 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The REDOX balance in the prefrontal cortex is positively modulated by aerobic exercise and altered by overfeeding

Scientific Reports
While obesity rates increase worldwide, physical activity levels are reduced. Obesity and physical inactivity may be inversely related to the production of reactive oxygen species (ROS) and cause oxidative stress in the central nervous system.
Deyvison Guilherme Martins Silva, Jonata Henrique de Santana, Elenilson Maximino Bernardo, Matheus Santos de Sousa Fernandes, Fatma Hilal Yagin, Fahaid Al-Hashem, Mariana P. Fernandes, Jarlei Fiamoncini, Safaa M. Elkholi, Claudia J. Lagranha   +9 more
doaj   +1 more source

Phenotypically Plastic Responses to Predation Risk Are Temperature Dependent [PDF]

, 2019
Predicting how organisms respond to climate change requires that we understand the temperature dependence of fitness in relevant ecological contexts (e.g., with or without predation risk).
Cressler, Clayton E., DeLong, John, Luhring, Thomas M., Vavra, Janna M.   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source