Results 31 to 40 of about 316,128 (141)

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Machleidt, Werner, Hoffmann, D., Assfalg-Machleidt, Irmgard, Helm, K. von der, Nitschko, H., Koszinowski, U.   +5 more
core   +1 more source

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

Parasites & Vectors, 2018
Background The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, which have already unblocked several essential steps along
Valérian Pasche, Benoît Laleu, Jennifer Keiser   +2 more
doaj   +1 more source

Computational models for prediction of yeast strain potential for winemaking from phenotypic profiles [PDF]

, 2013
Saccharomyces cerevisiae strains from diverse natural habitats harbour a vast amount of phenotypic diversity, driven by interactions between yeast and the respective environment. In grape juice fermentations, strains are exposed to a wide array of biotic
Mendes, Mendes, Dequin, Sylvie, Schuller, Dorit, João Drumonde-Neves, Ricardo Franco-Duarte, Inês Mendes, João Drumonde-Neves (433942), Mendes Inês, Fonseca Elza, Elza Fonseca (433941), Schuller, Dorit Elisabeth, Fonseca, Elza, Zupan Blaz, Lan Umek, Schuller Dorit, Sylvie Dequin (205208), Dorit Schuller (181699), Franco-Duarte, Ricardo, Sylvie Dequin, Dequin Sylvie, Dorit Schuller, Zupan, Blaz, Umek, Lan, Drumonde-Neves João, Mendes, Inês Isabel Moreira Moutinho Vieira, Lan Umek (433940), Drumonde-Neves, Joao, Umek Lan, Inês Mendes (433938), Elza Fonseca, Blaz Zupan (10031), Mendes, Ines, Franco-Duarte Ricardo, Ricardo Franco-Duarte (433939), Blaz Zupan   +34 more
core   +2 more sources

Glacial history affected phenotypic differentiation in the Alpine plant Campanula thyrsoides [PDF]

, 2013
Numerous widespread Alpine plant species show molecular differentiation among populations from distinct regions. This has been explained as the result of genetic drift during glacial survival in isolated refugia along the border of the European Alps ...
Scheepens J. F., Frei Eva S., J F Scheepens, Frei, E. S., J. F. Scheepens (471741), Eva S. Frei (471742), Jürg Stöcklin (471743), Stöcklin Jürg, Stöcklin, Jürg, Eva S Frei, Scheepens, J. F., Jürg Stöcklin   +11 more
core   +2 more sources

Phenotypic changes in different spinach varieties grown and selected under organic conditions [PDF]

, 2011
Organic and low-input agriculture needs flexible varieties that can buffer environmental stress and adapt to the needs of farmers. We implemented an experiment to investigate the evolutionary capacities of a sample of spinach (Spinacia oleracea L ...
Goldringer, I., Chable, V., Goldringer, Isabelle, Edith T. Lammerts van Bueren, Lammerts Van Bueren, E., Schermann, Nicolas, Nicolas Schermann, Serpolay, Estelle, Schermann, N., Isabelle Goldringer, Dawson, J.C., Chable, Veronique, Julie Dawson, Estelle Serpolay, Véronique Chable, Serpolay, E., Lammerts van Bueren, Edith, Dawson, Julie   +17 more
core   +1 more source

Unidirectional response to bidirectional selection on body size II. Quantitative genetics

Ecology and Evolution, 2020
Anticipating the genetic and phenotypic changes induced by natural or artificial selection requires reliable estimates of trait evolvabilities (genetic variances and covariances). However, whether or not multivariate quantitative genetics models are able
Arnaud Le Rouzic, Clémentine Renneville, Alexis Millot, Simon Agostini, David Carmignac, Éric Édeline   +5 more
doaj   +1 more source

The early evolution of rhynchosaurs

Frontiers in Ecology and Evolution, 2016
The rhynchosaurian archosauromorphs are an important and diverse group of fossil tetrapods that first appeared during the Early Triassic and probably became extinct during the early Late Triassic (early Norian).
Martin Daniel Ezcurra, Martin Daniel Ezcurra, Felipe eMontefeltro, Richard J Butler   +3 more
doaj   +1 more source

Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria.

PLoS ONE, 2020
BackgroundThe spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing (DST) provides important
Timothy E Butler, Aiden J Lee, Yongqiang Yang, Mitchell D Newton, Roli Kargupta, Sachidevi Puttaswamy, Shramik Sengupta   +6 more
doaj   +1 more source

The saprotrophic Pleurotus ostreatus species complex: late Eocene origin in East Asia, multiple dispersal, and complex speciation

IMA Fungus, 2020
The Pleurotus ostreatus species complex is saprotrophic and of significant economic and ecological importance. However, species delimitation has long been problematic because of phenotypic plasticity and morphological stasis.
Jing Li, Li-Hong Han, Xiao-Bin Liu, Zhi-Wei Zhao, Zhu L. Yang   +4 more
doaj   +1 more source

A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

Breast Cancer Research
Background Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype.
Joseph A. Caruso, Chira Chen-Tanyolac, Thea D. Tlsty   +2 more
doaj   +1 more source