Results 161 to 170 of about 390,444 (399)

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

open access: yesAdvanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen   +13 more
wiley   +1 more source

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway

open access: yesAdvanced Science, EarlyView.
Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li   +8 more
wiley   +1 more source

High‐Throughput MicroED for Probing Ion Channel Dynamics

open access: yesAdvanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito   +4 more
wiley   +1 more source

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

open access: yesAdvanced Science, EarlyView.
This study employs neutrophils for the precise delivery of anti‐CD47 antibodies, combined with bacterial outer membrane vesicles, to enhance macrophage phagocytic function in the tumor microenvironment. This approach effectively activates T‐cell anti‐tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and ...
Meng Guan   +15 more
wiley   +1 more source

A Phenylalanine Ammonia Lyase Capacitive Sensor for Phenylalanine Detection

open access: yesEurosensors 2023
In this paper, an easy-to-use and fast biosensor for phenylalanine quantification in patients affected by phenylketonuria is investigated. The phenylalanine concentration was indirectly estimated through the ammonia released as a by-product of an enzymatic reaction, which was then detected by exploiting an yttria-stabilized zirconia layer deposited ...
Bruno Andò   +9 more
openaire   +2 more sources

Phenylalanine‐Based DNA‐Encoded Chemical Libraries for the Discovery of Potent and Selective Small Organic Ligands Against Markers of Cancer and Immune Cells

open access: yesAdvanced Science, EarlyView.
FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini   +12 more
wiley   +1 more source

Exploring Hybrid Electrolytes for Zn Metal Batteries

open access: yesAdvanced Energy Materials, EarlyView.
The recent advance in the design of hybrid electrolytes for Zn metal batteries is comprehensively reviewed, covering their fundamental properties and classification. Moreover, the chemical strategies for the optimization of battery performances are systematically discussed.
Hao Fu   +7 more
wiley   +1 more source

Plant Phenylalanine/Tyrosine Ammonia-lyases.

open access: yesTrends in Plant Science, 2019
J. Barros, R. Dixon
semanticscholar   +1 more source

Cross‐Linked Protein Crystals With an Intense Nonconventional Full‐Color Photoluminescence Originating From Through‐Space Intermolecular Interaction

open access: yesAggregate, EarlyView.
Cross‐linked protein crystals are introduced as a novel class of nontraditional luminescent materials (NLMs) exhibiting tunable full‐color photoluminescence. Three polymorphic lysozyme crystals establish a clear, definitive structure–emission relationship, revealing that emission originates from intermolecular through‐space interactions (TSI).
Renbin Zhou   +7 more
wiley   +1 more source

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