Results 161 to 170 of about 394,077 (382)

A Phenylalanine Ammonia Lyase Capacitive Sensor for Phenylalanine Detection

open access: yesEurosensors 2023
In this paper, an easy-to-use and fast biosensor for phenylalanine quantification in patients affected by phenylketonuria is investigated. The phenylalanine concentration was indirectly estimated through the ammonia released as a by-product of an enzymatic reaction, which was then detected by exploiting an yttria-stabilized zirconia layer deposited ...
Bruno Andò   +9 more
openaire   +2 more sources

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

open access: yesAdvanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen   +13 more
wiley   +1 more source

Plant Phenylalanine/Tyrosine Ammonia-lyases.

open access: yesTrends in Plant Science, 2019
J. Barros, R. Dixon
semanticscholar   +1 more source

Confocal Absorbance‐Activated Droplet Sorting (cAADS) for Enzyme Engineering

open access: yesAdvanced Science, EarlyView.
A custom confocal absorbance‐activated droplet sorting (cAADS) platform is presented, which confines illumination and detection to a small area on the “droplet plane”, enabling enhanced sensitivity at ultrahigh throughput. System performances and versatility are demonstrated by screening Bilirubin Oxidase encapsulated in 10 pL droplets at 5.4 kHz ...
Abdi Mirgissa Kaba   +5 more
wiley   +1 more source

Phenylalanine‐Based DNA‐Encoded Chemical Libraries for the Discovery of Potent and Selective Small Organic Ligands Against Markers of Cancer and Immune Cells

open access: yesAdvanced Science, EarlyView.
FM‐DEL1 and FM‐DEL2 are constructed by installing one or two sets of building blocks on a phenylalanine central scaffold. FM‐DELs are screened against markers of prostate, and renal cell carcinoma, and against an immunological target expressed on the surface of natural killer cells.
Francesca Migliorini   +12 more
wiley   +1 more source

EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This review provides new perspectives on EGFR's activation, mutations, and their impact on tumor immunotherapy. It summarizes how EGFR is activated and the current EGFR targeting strategy, evaluates their clinical outcomes in combination with immunotherapy, highlighting differential responses in tumors with EGFR wild‐type and different mutants.
Yuanzhuo Gu   +7 more
wiley   +1 more source

Three phases in the evolution of the standard genetic code: how translation could get started [PDF]

open access: yes, 2007
A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like.
van der Gulik, Peter
core   +1 more source

Biohybrid Computing with Proteinoids and Algae

open access: yesAdvanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis   +1 more
wiley   +1 more source

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