Results 201 to 210 of about 425,330 (380)

Pregnancy in phenylketonuria: dietary treatment aimed at normalising maternal plasma phenylalanine concentration. [PDF]

, 1991
Greg Thompson, D. E. M. Francis, Denise M. Kirby, Richard C. Compton   +3 more
openalex   +1 more source

Boosting Reversible Photocontrol of a Photoxenase by an Engineered Conformational Shift

Angewandte Chemie, EarlyView.
Photocontrol of enzymes with photoswitchable unnatural amino acids hitherto yielded only limited light‐regulation factors (LRFs). Here we boosted the LRF of an imidazole glycerol phosphate synthase variant from ∼15 to ∼100 in a semi‐rational design approach and unraveled the mechanistic fundamentals of this effect via biophysical and computational ...
Sabrina Mandl, Janet Sánchez, Miquel Estévez, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld   +6 more
wiley   +2 more sources

Phenylalanine Lowers Melanin Synthesis in Mammalian Melanocytes by Reducing Tyrosinase Uptake: Implications for Pigment Reduction in Phenylketonuria

, 1980
Richard A. Farishian, J.H. Writtaker
openalex   +1 more source

Unveiling the phenylalanine coaggregation mechanism for a deep understanding of phenylketonuria disease. [PDF]

Sci Rep
Barazorda-Ccahuana HL, Mas F, Madurga S.
europepmc   +1 more source

Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins.

, 1992
Bruce A. Citron, Michael D. Davis, Sheldon Milstien, J.C. Gutiérrez, Dirk B. Mendel, Gerald R. Crabtree, Seymour Kaufman   +6 more
openalex   +2 more sources

Biosynthese der Biphenomycine, einer Familie potenter Antibiotika

Angewandte Chemie, EarlyView.
Der vollständige Biosyntheseweg der Biphenomycin‐Antibiotika wird aufgeklärt und offenbart eine einzigartige enzymatische Maschinerie mit einem bifunktionellen MNIO, einer regioselektiven Arginase, einem B12‐abhängigen rSAM für C,C‐Kupplung, Enzymen zur Hydroxylierung sowie einer zweifach spezifischen Metalloprotease.
Elisabeth Strunk, Alfred Lobert, Tatiana Khorovich, Katia M. Guzman Lucio, René Richarz, Maximilian Hohmann, Paul M. D'Agostino, Tobias A. M. Gulder   +7 more
wiley   +1 more source

Site‐Selective Peptide and Protein Functionalization with Cyclopropenium Cations

Angewandte Chemie, EarlyView.
A cysteine‐selective bioconjugation using aromatic cyclopropenium cations is reported. The reaction proceeds rapidly under aqueous conditions, enabling site‐selective installation of tetrasubstituted cyclopropene rings on peptides and proteins. The method shows preference for internal cysteines and provides conjugates that serve as efficient radical ...
Adriana Faraone, Matteo Balletti, Aliénor Jeandin, Hang‐Fei Tu, Viktoria A. Ikonnikova, Laura S. Sojka, Marcos G. Suero   +6 more
wiley   +2 more sources

The influence of professionals' personal views and values in the development of guidelines for rare diseases: an example from phenylketonuria. [PDF]

Orphanet J Rare Dis
van Wegberg AMJ, Romani C, van Spronsen FJ.   +2 more
europepmc   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +2 more sources

Phenylalanine-mediated reprogramming of lipid, pentose phosphate, and energy metabolism delays senescence in <i>Rosa roxbu</i> <i>rghii</i> fruit. [PDF]

Food Chem (Oxf)
Liu S, Zhang Y, Chang W, Zhou Y, Ding X, Dong B, Duan X.   +6 more
europepmc   +1 more source