ABSTRACT Grey mould, caused by Botrytis cinerea, is a significant postharvest disease leading to substantial economic losses in the grape industry. This study investigated the regulatory mechanism of 3‐methyl‐1‐butanol (3M1B), a yeast volatile substance, on B. cinerea resistance in red grapes (Vitis vinifera L.).
Shunjie Zhai +7 more
wiley +1 more source
THE IMPORTANCE OF DIET THERAPY IN THE TREATMENT OF PHENYLKETONURIA: A CASE REPORT
Phenylketonuria is the most common inborn error of amino acid metabolism. It is caused by the impossibility of converting the essential amino acid phenylalanine into tyrosine, most often due to insufficient production or a complete lack of the enzyme ...
Nikolina Gaćina, Jerko Vučak
doaj +1 more source
Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators
Herein we report the discovery of new modulators of human phenylalanine hydroxylase (hPAH) inspired by the structure of its substrate and regulatorl-phenylalanine.
Francesco Montalbano +7 more
openaire +1 more source
Chronic Immune Stimulation May Cause Moderate Impairment of Phenylalanine 4-hydroxylase
Phenylalanine (4)-hydroxylase (PAH, E.C. 1.14.16.1) is located mainly in liver and converts amino acid phenylalanine (Phe) to tyrosine (Tyr). In 'classical' phenylketonuria (PKU), PAH activity is reduced, whereas in 'atypical' PKU biosynthesis of the ...
Scholl-Bürgi S +4 more
doaj +1 more source
Mechanism of phenylalanine regulation of phenylalanine hydroxylase.
The mechanism of phenylalanine regulation of rat liver phenylalanine hydroxylase was studied. We show that phenylalanine "activates" phenylalanine hydroxylase, converting it from an inactive to active form, by binding at a true allosteric regulatory site.
R, Shiman, S H, Jones, D W, Gray
openaire +2 more sources
Coenzyme Q10 deficiencies: pathways in yeast and humans. [PDF]
Coenzyme Q (ubiquinone or CoQ) is an essential lipid that plays a role in mitochondrial respiratory electron transport and serves as an important antioxidant.
Awad, Agape M +5 more
core
Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence [PDF]
Grape quality and yield can be impaired by bunch rot, caused by the necrotrophic fungus Botrytis cinerea. Infection often occurs at flowering, and the pathogen stays quiescent until fruit maturity.
Agudelo-Romero +102 more
core +1 more source
WRKY Transcription Factors: Integral Regulators of Defence Responses to Biotic Stress in Crops
ABSTRACT Crops are continually challenged by biotic stresses, including fungal, bacterial and viral pathogens and insect pests, which cause substantial yield and quality losses worldwide. WRKY transcription factors constitute a plant‐specific and functionally diverse family that is central to immune regulation.
Dongjiao Wang +8 more
wiley +1 more source
PAH and QDPR deficiency associated mutations in the Novosibirsk region of the Russian Federation: Correlation of mutation type with disease manifestation and severity [PDF]
Background: Efficient treatment of inherited hyperphenylalaninemia requires exact identification of mutations defining the trait. Such knowledge is important both for effective individual therapy and understanding of the genetic history and evolution of ...
Baturina Olga A. +4 more
doaj
Identification and characterization of the PhhR regulon in Pseudomonas putida [PDF]
Pseudomonas putida is a soil microorganism that utilizes aromatic amino acids present in root exudates as a nitrogen source. We have previously shown that the PhhR transcriptional regulator induces phhAB genes encoding a phenylalanine hydroxylase.
Duque, Estrella +4 more
core +2 more sources

