Results 61 to 70 of about 165,999 (264)

ProtVec: A Continuous Distributed Representation of Biological Sequences [PDF]

PLoS ONE 10(11): e0141287, 2015, 2015
We introduce a new representation and feature extraction method for biological sequences. Named bio-vectors (BioVec) to refer to biological sequences in general with protein-vectors (ProtVec) for proteins (amino-acid sequences) and gene-vectors (GeneVec) for gene sequences, this representation can be widely used in applications of deep learning in ...
arxiv   +1 more source

Stabilization of Tryptophan Hydroxylase 2 by L-Phenylalanine Induced Dimerization [PDF]

, 2016
Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate‐limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia.
Boesen, Jane, Christensen, Hans Erik Mølager, Harris, Pernille, Hoeck, Niclas, Peters, Günther H.J., Tidemand, Kasper Damgaard   +5 more
core   +1 more source

A New DNA Sequences Vector Space on a Genetic Code Galois Field [PDF]

The final version of the paper is published in the journal: MATCH Commun. Math. Comput. Chem. Volume 54 (2005), number 1 , pp. 3-28., 2004
A new n-dimensional vector space of the DNA sequences on the Galois field of the 64 codons (GF(64)) is proposed. In this vector space gene mutations can be considered linear transformations or translations of the wild type gene. In particular, the set of translations that preserve the chemical type of the third base position in the codon is a subgroup ...
arxiv  

A search for mid-IR bands of amino acids in the Perseus Molecular Cloud [PDF]

arXiv, 2023
Amino acids are building-blocks of proteins, basic constituents of all organisms and essential to life on Earth. They are present in carbonaceous chondrite meteorites and comets, but their origin is still unknown. We present Spitzer spectroscopic observations in the star-forming region IC 348 of the Perseus Molecular Cloud showing the possible ...
arxiv  

Phenylalanine hydroxylase: Function, structure, and regulation

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2013
Mammalian phenylalanine hydroxylase (PAH) catalyzes the rate‐limiting step in the phenylalanine catabolism, consuming about 75% of the phenylalanine input from the diet and protein catabolism under physiological conditions.
M. Flydal, Aurora Martínez
semanticscholar   +1 more source

Biopterin responsive phenylalanine hydroxylase deficiency [PDF]

Genetics in Medicine, 2004
Phenylketonuria (PKU) is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene. There have been more than 400 mutations identified in the PAH gene leading to variable degrees of deficiency in PAH activity, and consequently a wide spectrum of clinical severity.
Anne Romstad, Kathryn Moseley, Sankar Surendran, Alejandra Gámez, Stephen K. Tyring, Richard Koch, Reuben Matalon, Lisbeth Birk Møller, Raymond C. Stevens, Kimberlee Michals-Matalon, Kimberlee Michals-Matalon, Heidi Erlandsen, Flemming Güttler   +12 more
openaire   +3 more sources

A Novel Lie Algebra of the Genetic Code over the Galois Field of Four DNA Bases [PDF]

arXiv, 2005
By starting from the four DNA bases order in the Boolean lattice, a novel Lie Algebra of the genetic code is proposed. Here, the principal partitions of the genetic code table were obtained as equivalent classes of quotient subspaces of the genetic code vector space over the Galois field of the four DNA bases.
arxiv  

CPMD simulation of Cu2+ -- phenylalanine complex under micro-solvated environment [PDF]

arXiv, 2013
The study combines DFT calculations and CPMD simulations to investigate the structures of phenylalanine-copper (II) ([Phe-Cu]2+) complexes and the micro-solvation processes. ....It is found that the phenylalanine moiety appears to be in the neutral form in isolated and mono-hydrated complexes, but in the zwitterionic form in other hydrated complexes ...
arxiv  

Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism [PDF]

, 2004
The first enzyme of the phenylpropanoid pathway, Phe ammonia-lyase (PAL), is encoded by four genes in Arabidopsis thaliana. Whereas PAL function is well established in various plants, an insight into the functional significance of individual gene family ...
Boerjan, Wout, De Rycke, Riet, Goeminne, Geert, Hostyn, Vanessa, Joseleau, Jean-Paul, Kushnir, Sergei, Messens, Eric, Morreel, Kris, Ralph, John, Rohde, Antje, Van Beeumen, Jozef, Van Doorsselaere, Jan, Van Driessche, Gonzalez, Vuylsteke, Marnik   +13 more
core   +3 more sources

Kinetic mechanism of phenylalanine hydroxylase: intrinsic binding and rate constants from single-turnover experiments.

Biochemistry, 2013
Phenylalanine hydroxylase (PheH) catalyzes the key step in the catabolism of dietary phenylalanine, its hydroxylation to tyrosine using tetrahydrobiopterin (BH(4)) and O(2).
K. Roberts, J. A. Pavon, P. Fitzpatrick
semanticscholar   +1 more source