The Molecular Basis of Amino Acids Sensing
Advanced Science, Volume 12, Issue 26, July 10, 2025.Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang +3 more
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Conventional Phenylketonuria Treatment
Journal of Inborn Errors of Metabolism and Screening, 2016 Phenylketonuria (PKU) is caused by a deficient activity of enzyme phenylalanine (Phe) hydroxylase, which results in high Phe blood concentration, which is toxic to the central nervous system.
Guillén-López Sara MS, RD +3 more
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Screening and mutation analysis of phenylalanine hydroxylase deficiency in newborns from Jiangxi province. [PDF]
Front Genet, 2023 Zeng B +9 more
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An Update: Enzymatic Synthesis for Industrial Applications
Angewandte Chemie International Edition, Volume 64, Issue 27, July 1, 2025.Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer +4 more
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In Silico Structural Protein Evaluation of the Phenylalanine Hydroxylase p.(Tyr77His) Variant Associated with Benign Hyperphenylalaninemia as Identified through Mexican Newborn Screening. [PDF]
Children (Basel), 2023 Vela-Amieva M +7 more
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BAF60/SWP73 subunits define subclasses of SWI/SNF chromatin remodelling complexes in Arabidopsis
New Phytologist, Volume 247, Issue 2, Page 791-812, July 2025.Summary Evolutionarily conserved switch‐defective/sucrose nonfermentable (SWI/SNF) ATP‐dependent chromatin remodelling complexes (CRCs) alter nucleosome positioning and chromatin states, affecting gene expression to regulate important processes such as proper development and hormonal signalling pathways.
Sebastian P. Sacharowski +23 more
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Cell Transplantation, 2012 Phenylketonuria is a metabolic disease caused by phenylalanine hydroxylase deficiency. Treatment is based on a strict natural protein-restricted diet that is associated with the risk of malnutrition and severe psychosocial burden.
X. Stéphenne +14 more
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Thermodynamics of iron, tetrahydrobiopterin, and phenylalanine binding to phenylalanine hydroxylase from Chromobacterium violaceum. [PDF]
Arch Biochem Biophys, 2022 Li M +3 more
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Different Phenotypes for Phenylalanine Hydroxylase Deficiency [PDF]
, 1977 F. Güttler, Gert H. Hansen
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