Results 81 to 90 of about 32,654 (265)

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo [PDF]

, 2017
The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the ...
Danecka, Marta K., Domdey, Katharina A., Eichinger, Anna, Fingerhut, Ralph, Gersting, Søren W., Glossmann, Hartmut, Kemter, Kristina F., Lagler, Florian B., Messing, Dunja D., Muntau, Ania C., Roscher, Adelbert A., Staudigl, Michael, Zsifkovits, Clemens   +12 more
core  

A Repression‐Activation System Involving miR164a‐NACs Regulates Tissue‐Specific Anthocyanin Accumulation in Peach Fruit

Plant Biotechnology Journal, EarlyView.
ABSTRACT Anthocyanins are often responsible for fruit colour, determining their commercial value and providing nutritional benefits. In this study, differential anthocyanin accumulation in peel, outer flesh near the peel (OF) and inner flesh around the stone (IF) was observed in two peach fruit cultivars.
Ling Liang, Jiazhen Zhu, Wanyi Yang, Shaojie Ai, Wenqiu Wang, Xueren Yin, Kui Lin‐Wang, Andrew C. Allan, Kunsong Chen, Changjie Xu   +9 more
wiley   +1 more source

CYP82G1 Enzyme Functions as Chromone Hydroxylase in the Biosynthesis of 6‐Hydroxy‐2‐(2‐Phenylethyl)chromone in Aquilaria sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Aquilaria sinensis, a plant of the genus Aquilaria in the family Thymelaeaceae, can form resinous and fragrant agarwood in response to wounding or infection. The resin physically occludes xylem vessels and ray parenchyma, limiting pathogen mobility and resource loss.
Wenli Wu, Tingting Yan, Yuanyuan Zhao, Xuan Zhang, Iain Wilson, Gaiyun Li, Hao Wang, Wenli Mei, Ruibo Wu, Xiaochen Sun, Luyuan Jiang, Xiaoyang Jiang, Fenjuan Shao, Deyou Qiu   +13 more
wiley   +1 more source

Phenylketonuria: Protein content and amino acids profile of dishes for phenylketonuric patients. The relevance of phenylalanine [PDF]

, 2014
Phenylketonuria is an inborn error of metabolism, involving, in most cases, a deficient activity of phenylalanine hydroxylase. Neonatal diagnosis and a prompt special diet (low phenylalanine and natural-protein restricted diets) are essential to the ...
Almeida, Manuela F., Alves, Rita C., Costa, Anabela S. G., Oliveira, M. Beatriz P. P., Pimentel, Filipa B., Torres, Duarte   +5 more
core   +1 more source

Polyacylated Delphinidin Biosynthesis Catalysed by PhF3′5′H‐PhBGLU12‐PhSCPL2 Determines the Blue Pigmentation in Cineraria (Pericallis hybrida)

Plant Biotechnology Journal, EarlyView.
ABSTRACT The polyacylation modification of anthocyanins constitutes a pivotal step for plants to develop persistent bright blue floral pigmentation, but the biosynthesis and regulatory mechanisms of polyacylated anthocyanin remain poorly understood.
Yumeng Cui, Jiangshan Ren, Jiawei Fan, Hao Li, Yi Li, Yuqing Ye, Jingwen Wu, Fangting Qi, Silan Dai, He Huang   +9 more
wiley   +1 more source

Food Regime for Phenylketonuria: Presenting Complications and Possible Solutions

Journal of Multidisciplinary Healthcare, 2022
Sudipt Kumar Dalei, Nidhi Adlakha Regional Center for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, IndiaCorrespondence: Nidhi Adlakha Email nidhi.adlakha@rcb.res.inAbstract: In the category of rare inherited genetic disorders ...
Kumar Dalei S, Adlakha N
doaj  

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Phenylketonuria [PDF]

, 2004
Genome research is emerging as a new and important tool in biology used to obtain information on gene sequences, genomic interaction, and how genes work in concert to produce the final syndrome or phenotype. Defect in phenylalanine hydroxylase (PAH) gene
Matalon, Reuben, Michals-Matalon, Kimberlee, Surendran, Sankar, Tyring, Stephen K.   +3 more
core  

The cardiovascular phenotype of adult patients with phenylketonuria [PDF]

, 2019
BACKGROUND: Patients with Phenylketonuria (PKU) are exposed to multiple cardiovascular risk factors, but the clinical significance of these abnormalities is yet unknown.
Azabdaftari, Aline, Giet, Markus van der, Hennermann, Julia B., Plöckinger, Ursula, Querfeld, Uwe, Schuchardt, Mirjam   +5 more
core   +1 more source