Results 21 to 30 of about 61,478 (225)

Non-invasive Evaluation of Aortic Stiffness Dependence with Aortic Blood Pressure and Internal Radius by Shear Wave Elastography and Ultrafast Imaging [PDF]

, 2018
Elastic properties of arteries have long been recognized as playing a major role in the cardiovascular system. However, non-invasive in vivo assessment of local arterial stiffness remains challenging and imprecise as current techniques rely on indirect ...
Dizier, B., Messas, E., Mirault, T., Papadacci, Clement, Pernot, M., Tanter, M.   +5 more
core   +3 more sources

Comparison of phenylephrine and norepinephrine for prevention of hypotension in patients undergoing cesarean section under spinal anesthesia – A randomized prospective study

Journal of Obstetric Anaesthesia and Critical Care, 2022
Background: Hypotension is a common side effect of spinal anesthesia for cesarean section with incidence of upto 71%. Various vasopressors are available for counteracting spinal hypotension each with different pharmacological profile.
Wakhloo Renu, Bhagat Heena, Gandotra Megha, Suri Era   +3 more
doaj   +1 more source

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]

, 2019
Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A., Bernstein, Daniel, Brandimarto, Jeff, Cappola, Thomas, Chang, Alex C., Chin, Elizabeth T., Connolly, Andrew, Cordero, Pablo, Depaoli-Roach, Anna A., Dewey, Frederick, Erbilgin, Ayca, Glazer, Nicole, Gloudemans, Michael J., Hakonarson, Hakon, Hannenhalli, Sridhar, Huang, Yong, Li, Hongzhe, Li, Mingyao, Lusis, Aldons J., Malloy, Christine, Margulies, Kenneth B., Montgomery, Stephen B., Moravec, Christine S., Morley, Michael, Parikh, Victoria N., Pavlovic, Aleksandra, Ritter, Scott, Shang, Ching, Skreen, Jamie, Smith, Kevin S., Tang, W. H. Wilson, Waggott, Daryl, Wheeler, Matthew T., Zaleta, Kathia, Zhao, Mingming   +34 more
core   +2 more sources

Prophylactic Phenylephrine Increases the Dose Requirement of Oxytocin to Treat Uterine Atony During Cesarean Delivery: A Double-Blinded, Single-Center, Randomized and Placebo-Controlled Trial

Frontiers in Pharmacology, 2021
Purpose: Studies involving mouse models and human uterine smooth muscle cells have shown that phenylephrine inhibits uterine contractions in non-pregnant mice and human in vitro cell via cyclic adenosine monophosphate (cAMP) signaling. However, there has
Yao-Hua Shen, Fan Yang, Li-Dan Jin, Yu-Jia Qian, Li Xing, Ya-Li Huang, Su-Feng Lin, Fei Xiao   +7 more
doaj   +1 more source

Phenylephrine as an alternative to cocaine for nasal vasoconstriction before nasal surgery: A randomised trial

Indian Journal of Anaesthesia, 2013
Background: Cocaine is often used topically to provide the profound vasoconstriction required for nasal surgery; however, it has been associated with intraoperative cardiac adverse effects.
Sawsan T AlHaddad, Ashish K Khanna, Edward J Mascha, Basem B Abdelmalak   +3 more
doaj   +1 more source

Sex-Dependent Effects of Angiotensin II and Calcineurin in the Vasculature of Mice. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Cardiovascular diseases display strong sex differences. Angiotensin II (AngII) is implicated in this process. The ubiquitously expressed enzymatic beta subunit of calcineurin (PPP3CB), a serine/threonine phosphatase, can mediate pathological effects of AngII in the heart.
Nolze A, Rabe S, Ruhs S, Strätz N, Quarch K, Köhler C, Grossmann C.   +6 more
europepmc   +2 more sources

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function [PDF]

, 2014
<b>Objective:</b><p></p> Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies.
Adlam, Cai, Calhoun, Chacko, Chandran, DAgostino, Dai, Dai, Dikalova, Doughan, Evans, Flores-Munoz, Flores-Munoz, Gane, Graham, Graham, Gutierrez, Halliwell, Jalil, Jeffs, Landmesser, London, Lowes, Mercer, Messerli, Murphy, Murphy, Nakagami, Nakamura, Nozoe, Qin, Rajagopalan, Roman, Ross, Snow, Watkins, Winterbourn, Yang, Yasunari, Zhang, Zhang, Zorov   +41 more
core   +1 more source

Efficacy of fixed-dose phenylephrine bolus for treating post-spinal hypotension: Comparison between pre-eclamptics and normotensives

Journal of Anaesthesiology Clinical Pharmacology, 2023
Background and Aims: Pre-eclamptic parturients may have an exaggerated response to vasopressors. This study compares the efficacy of a 50 μg fixed bolus of phenylephrine for treatment of post-spinal hypotension in pre-eclamptic versus normotensive ...
Rashmi Salhotra, Asha Tyagi, Rajesh Singh Rautela, Jainendra Chauhan, Lhamo Dolma, Ankit Sharma, Prerna Batra, Himsweta Srivastava   +7 more
doaj   +1 more source

Stability of extemporaneously prepared ophthalmic solutions for mydriasis [PDF]

, 2018
Purpose Results of an evaluation of the physical and chemical stability of extemporaneously prepared adult and pediatric ophthalmic solutions containing combinations of phenylephrine, tropicamide, and cyclopentolate are reported.
Camp, Nicole A., Gilbert, Justine M., Hughes, Susan E., Nadra, Jennifer T., Zhao, Fang   +4 more
core   +2 more sources

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis [PDF]

, 2017
Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process.
Ceravolo, Graziela, Graham, Delyth, Harvey, Adam P., Hood, Katie Y., Lopes, Rheure A., Montezano, Augusto C., Rios, Francisco, Touyz, Rhian M.   +7 more
core   +1 more source