Results 131 to 140 of about 45,755 (304)

Plasiatine, an Unprecedented Indole-Phenylpropanoid Hybrid from Plantago asiatica as a Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2

, 2016
Plasiatine (1), isolated from the seeds of Plantago asiatica, is an unprecedented indole analogue linked to a phenylpropanoid moiety via a carbon bond that builds up a novel heteromeric construction with a C19N2 scaffold.
Wang, X, Xiao, WL (reprint author), Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China., Peng, HP, Xiao, WL, Shi, YM, Gao, ZH, Ji, X, Yang, Y, Wang, F, Du, BW, Li, HL (reprint author), E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China., Qiang, Z, Li, HL, Wang, F (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Shang, SZ   +14 more
core   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Multi-target Phenylpropanoids Against Epilepsy

Current Neuropharmacology
: Epilepsy is a neurological disease with no defined cause, characterized by recurrent epilep- tic seizures. These occur due to the dysregulation of excitatory and inhibitory neurotransmitters in the central nervous system (CNS). Psychopharmaceuticals have undesirable side effects; many patients require more than one pharmacotherapy to control crises.
Rodrigues, Teresa Carolliny Moreira Lustoza, Dias, Arthur Lins, dos Santos, Aline Matilde Ferreira, Messias Monteiro, Alex France, Oliveira, Mayara Cecile Nascimento, Oliveira Pires, Hugo Fernandes, de Sousa, Natália Ferreira, Salvadori, Mirian Graciela da Silva Stiebbe, Scotti, Marcus Tullius, Scotti, Luciana   +9 more
openaire   +2 more sources

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

sj-doc-1-npx-10.1177_1934578X241239835 - Supplemental material for Expression Analysis of Phenylpropanoid Pathway Genes and Phenylpropanoid Accumulation in Different Organs of Chelidonium majus L.

Supplemental material, sj-doc-1-npx-10.1177_1934578X241239835 for Expression Analysis of Phenylpropanoid Pathway Genes and Phenylpropanoid Accumulation in Different Organs of Chelidonium majus L.
Sang Un Park (415822), Nam Il Park (422073), Ramaraj Sathasivam (9721990), Yong Suk Chung (8444100), Chanung Park (18266097), Haejin Kwon (13967193), Jiwon Yoon (6655379)   +6 more
core   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Three biologically active phenylpropanoid glucosides from Myriophyllum verticillatum

, 1992
Three novel phenylpropanoid glucosides have been isolated from a methanolic extract of Myriophyllum verticillatum and their structures defined by spectroscopic methods and chemical degradations.
P. MONACO, G. Pinto e. L. Previtera, A. MOLINARO, PINTO, GABRIELE, G. ALIOTTA, L. PREVITERA, MONACO, Pietro   +6 more
core   +1 more source

Plant‐derived compounds to improve soil inoculation for restoration

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Restoring the soil microbiome is increasingly recognized as an important requirement for the success of ecosystem restoration. Soil inoculation can reintroduce the missing taxa, but its application is limited by the large amount of donor soil that is needed and by the ...
Farzad Aslani, Sofia I. F. Gomes, T. Martijn Bezemer   +2 more
wiley   +1 more source

Tree species identity is associated with rhizosphere microbiome assembly via root metabolite‐mediated feedbacks in subtropical forests

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The rhizosphere microbiome is critical for forest ecological functions, yet the mechanisms through which tree species identity and neighbour tree interactions are associated with its assembly remain poorly understood.
Yuemei Zhang, Junchen Ye, Yao Kang, Yangchunzi Liao, Ziwen Jiao, Wenjing Meng, Lin Chang, Bing Liu, Yilin Li, Ziwen Gao, Ning Li, Hui Sun, Lin Huang   +12 more
wiley   +1 more source