Results 101 to 110 of about 92,765 (376)

Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients

Case Reports in Transplantation, 2013
The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations.
A. Jantz, Samir J. Patel, W. Suki, R. Knight, A. Bhimaraj, A. Gaber   +5 more
semanticscholar   +1 more source

Saliva as a TDM matrix and its application in the model‐informed precision dosing

The Journal of Clinical Pharmacology, EarlyView.
Abstract This study reviews the main points of saliva as a therapeutic drug monitoring (TDM) matrix, its advantages and limitations, the methods of saliva sample collection and testing, the types of drugs in saliva TDM, and the methods of establishing saliva population pharmacokinetic (Pop PK) models, as well as summarizes the experiences and ...
Baohua Xu, Yujie Wen, Jinxia Lu, Maobai Liu, Xin Luo, Wei Huang, Helin Xie, Yu Cheng, Hongqiang Qiu, Xuemei Wu   +9 more
wiley   +1 more source

Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights

Journal of Pharmacy & Pharmaceutical Sciences, 2018
PURPOSE: The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability, safety ...
Daniela Amaral Silva, Raimar Löbenberg, Neal Davies   +2 more
doaj   +1 more source

Quantification of Dynamic 11C-Phenytoin PET Studies [PDF]

, 2015
The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp.
Bakker, Esther D.M., Boellaard, Ronald, Froklage, Femke E., Lammertsma, Adriaan, Mansor, Mohd Syahir, Schwarte, Lothar A., Verbeek, Joost, Voskuyl, Rob A., Windhorst, Albert D., Yaqub, Maqsood   +9 more
core   +1 more source

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Pharmaceuticals, 2018
Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with positive
David J. Kopsky, Jan M. Keppel Hesselink   +1 more
doaj   +1 more source

The acrocallosal syndrome: A case report and literature survey [PDF]

, 2009
Acrocallosal syndrome (ACS) is a rare, genetically transmitted disorder characterized by facial deformities. These include a large forehead, large anterior fontanelle, broad nasal bridge with increased intercanthal distance, partial or complete agenesis ...
Davies, Lindsey, Gonzales, Cesar, Hodgson, Brian   +2 more
core   +1 more source

Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers [PDF]

, 2012
To compare and evaluate the bioavailability for intravenous fosphenytoin sodium with that of intravenous phenytoin sodium in Japanese subjects. In study 1, healthy Japanese male volunteers received a 30-min infusion of 375 mg fosphenytoin sodium or an ...
Kenji Shimizu, Naotaka Usui, Shigeki Shimasaki, Susumu Kobayashi, Tadayuki Hiroki, Yushi Inoue   +5 more
core   +1 more source

A geriatrician's approach to managing the complex older adult with obesity

Obesity, EarlyView.
Abstract The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight‐loss attempts during the middle years of life ...
Shenbagam Dewar
wiley   +1 more source

The Effect of Sample Storage Temperature on the Phenytoin Level in Serum

Siriraj Medical Journal, 2015
Objective: To study the effect of temperature on phenytoin concentration in serum and to determine the sample were kept at 2-8°C and 35°C. Methods: Serum samples of patients, who had been treated with phenytoin.
Paiboon Tummarintra
doaj   +2 more sources

Plasmapheresis as an Adjunctive Therapy in Phenytoin Poisoning

Global Journal of Transfusion Medicine
Phenytoin is frequently used as an anticonvulsant. Phenytoin has saturable metabolic kinetics in overdose circumstances, making therapy challenging. Because of its high protein binding property, the usual hemodialysis and hemoperfusion are not usually ...
Purshotam Paudel, Dibyajyoti Sahoo, Abhishekh Basavarajegowda, Raushan Afroz   +3 more
doaj   +1 more source